Ukuqaphela iimpawu ze-PML kunye nezo-MS kwakhona
I-prolonged multifocal leukoencephalopathy (PML), iyinto engaqabile kodwa isifo esibuhlungu esibangelwa yi -JC . Le ntsholongwane ibanjwe ngethungelwano ngamajoni akho omzimba ukuze kungabangeli umonakalo.
Nangona kunjalo, ukuba isistim somzimba sakho sisifo ngenxa yesifo, njenge- HIV / AIDS , i- leukemia , i-lymphoma, okanye omnye umhlaza, okanye ugxothwe ngamachiza, intsholongwane ingakwazi ukuvuselela nokulimaza ingqondo yakho.
Umonakalo wengqondo obangelwa yi-PML unokukhokelela kwiimpawu ezahlukeneyo.
Ngelixa i-PML inqabile kakhulu, yinto enokukhathazeka xa unesifo se-sclerosis (MS) ngenxa yokuba amanye amayeza angasetyenziswayo ukunyanga eso sifo akwandisa umngcipheko wokuphuhlisa i-PML.
I-Tysabri (natalizumab) ibonakala ihambelana nomngcipheko omkhulu we-PML. Nangona kunjalo, amanye amayeza e-immunosuppressive MS angasenza umngcipheko, kuquka iGilenya (fingolimod), iTecfidera (dimethyl fumarate), i-Ocrevus (ocrelizumab), kwaye mhlawumbi nabanye.
Izimpawu ze-PML
I-MS ngokwayo ayinyuli umngcipheko we-PML. Kodwa ukuba wena okanye othandekayo uthatha imishanguzo yokuguqula izifo ezithintela umzimba wokuzivikela, ukuziqonda ngeempawu ze-PML kukuvumela ukuba usebenze kwaye unolwazi ekujongeni le nkxalabo enzima.
Njengempawu ze-MS, abo bahlobana ne-PML bahluka, kuxhomekeke kwimimandla yengqondo echaphazelekayo.
Iimpawu zingabandakanya:
- Ubuthathaka, ngokuqhelekileyo kwelinye icala lomzimba
- Amandla okucinga okungaziphathi kakuhle, okusoloko ebonisa ukudideka kunye / okanye ukulahleka kwememori
- Unzima ukuthetha
- Ukulungelelanisa kakubi, ngokuqhelekileyo njengamava okanye ukuhamba ubunzima
- Iingxaki ezibonakalayo, ezifana nombono ongenakwenzeka okanye ukungaboni ngokucacileyo kwindawo ethile yembonakalo yakho
- Utshintsho lwabantu
- Uvakalelo olungaqhelekanga okanye ukulahlekelwa kwintlungu kwindawo yomzimba wakho
- Ukuqubuka, nangona oku kuqhelekanga
I-PML ne-MS kwakhona
Iimpawu ze-PML zisoloko zingabonakaliyo kwii-MS kwakhona. Oku akumangalisi kuba zombini izifo zidala ukutshabalalisa, ukutshatyalaliswa kwezinto ezikhuselekileyo ezijikelezayo. Ukulahlekelwa kwesi sixhobo sokukhusela, esibizwa ngokuthi i-myelin, siphazamisa ukuhanjiswa kweempawu zombane phakathi kwengqondo yakho nomzimba.
Ngenxa yokuba iimpawu ze-PML kunye ne- MS kwakhona ziyakwazi ukufana, kunzima ukufumanisa i-PML kwizigaba zokuqala zesifo. Oko kwathiwa, isantya sokuphuhliswa kweempawu ezintsha yinkcazelo enceda ukunqunyanisa ukuba ngaba ngenxa ye-PML okanye i-MS kwakhona. Iimpawu ze-PML azifaneki ngokuzenzekelayo kodwa kunoko ziphuhlise kwaye ziqhubele phambili kwiintsuku ukuya kwiiveki.
Oogqirha banokucacisa ngokucacileyo ukuhlula i-PML esuka kwi-MS ngokuvavanya ngokucophelela iimpawu zomntu. Ngenxa yokuba i-PML yintsholongwane yesifo sengqondo, isoloko ibangela uphawu olungaphezulu kwesinye okanye olubi kakhulu, ngelixa uphawu olulodwa lunokuthi lubuyele kwakhona kwi-MS. Nangona kunjalo, oku kungumqondiso, kungekhona umgaqo onzima.
Enye indlela ebalulekileyo yokwahlula i-PML kwi-MS kwakhona yokuhlola i-MRI scan yomntu ochaphazelekayo ngengqondo.
Njenga-MS, i-PML ibangela izilonda zobuchopho ezibonakalayo kwi-MRI, kodwa zivame ukuhlukana nezilonda ze-MS ngobukhulu, imo, indawo kunye nezinye iimpawu.
Umtshini wokugada ukuhlola i-cerebrospinal fluid kwi-JC virus isetyenziswe ukuqinisekisa ukuxilongwa kwe-PML. Ekugqibeleni, i-brain biopsy idlalwa ngamanye amaxesha.
ILizwi
Siyaqonda ukuba nokuba kunokwenzeka ukuba kude kube nokuphuhlisa i-PML kukuxhalabisa kakhulu xa uthatha imithi ethile yokuguqula izifo ze-MS. Ukuba ukhona kwiTysabri, i-Gilenya, i-Tecfidera, i-Ocrevus, okanye enye imithi yokugonya imithi ye-MS kwaye uqaphele nayiphina impawu emitsha okanye eyingozi, qha ga mshelana nodokotela wakho.
Nangona le miqondiso ayisoloko ibonisa ukuphuhliswa kwe-PML, kuyadingeka ukuba kuhlolwe uvavanyo lwezonyango kuba le ntsholongwane engabonakaliyo yintsholongwane yobomi iyingozi. Ukuxilongwa kwangaphambili kukunika ithuba elihle lokuba nesiphumo esihle xa uhlakulela i-PML.
> Imithombo:
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> Greenlee JE. I-Progressive Multifocal Leukoencephalopathy (PML). Ku: Porter RS, Kaplan JL, Lynn RB, et al. I-Merck Manual Professional Professional Version .
> Maas RPPWM, Muller-Hansma AHG, Esselink RAJ, et al. I-Associate-Progressive Multifocal Leukoencephalopathy: I-Clinical, Radiological, kunye neCerebrospinal Analysis of Fluid Analysis of 326 Cases. J Neurol . 2016; 263 (10): 2004-2021.
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