Ngaba i-Xopenex ingcono kune-Albuterol?
I-Xopenex (i-levalbuterol) yinyango ekhuselweyo yokunyanga iimpawu ze- asthma eziphambili, kuquka ukukhwehlela, ukuvutha, ukuphefumula nokuphefumula kwesifuba. I-Xopenex isebenza ngokuphumla izihlunu ezihamba kakuhle emiphakeni, ngokuqhelekileyo phakathi kwemizuzu embalwa yokuthatha leyeza. I-Xopenex ifumaneka kokubili njenge-inhaler kunye nesifomso esithunyelwa nge- nebulazer .
I-Xopenex ngumsizi osebenzayo we- albuterol (obizwa ngokuba yi-R-albuterol okanye i-levalbuterol). Izakhiwo zeekhemikhali zonyango zikhona njengomxube weemifanekiso zemibukiso yomnye nomnye (okubhekiswa njengengxube yezobuhlanga ), kwaye enye yile fomu yonyango elisebenzayo. Ifomu engasebenzi (ebizwa ngokuba yi-S-albuterol okanye i-dextroalbuterol) ayinanto ngaphandle kokuba "ihamba ngendlela" yefomu esebenzayo kwaye isenokufaka isandla kwimiphumo emibi. Le nto yayiyinjongo yokuba kutheni i-Xopenex yaphuhliswa - ukuphucula umsebenzi we-albuterol ngelixa kuphungula imiphumo emibi.
Ngaba i-Xopenex engcono kune-Albuterol ye-Asthma?
Akucaci ngokupheleleyo. Xa i-Xopenex yaqala ukuphuhliswa, izifundo zezilwanyana zaphakamisa ukuba i-S-albuterol ibangele ukuvuvukala emiphakeni, enokuthi ibenzi ngakumbi. Kwaye kucatshangelwa ukuba njenge-albuterol engaphezulu (umxube we-R kunye ne-S-albuterol isomers) ithathwe, i-S-albuterol isomerom yayiza kuqokelela emiphakeni kwaye ibangele ukungqubuzana kwemisipha ephosakeleyo emiphakeni, ngoku kwandisa impawu ze-asthma .
I-Xopenex yayilindeleke ukuba isebenze kangcono ekuphatheni iimpawu zesifo se- asthma kune-albuterol enobuhlanga.
Izifundo zakuqala zabonisa ukuba i-Xopenex yayingcono ekupheni i-asthma kune-albuterol, kuba i-Xopenex encinane yayidinga ukuphumeza iimpawu ze-asthma kuneemali ezifana ne-albuterol. Ekubeni i-Xopenex iyisiqingatha esisebenzayo se-albuterol, umntu unokulindela ukuba isiqingatha somthamo we-Xopenex siya kufana ne-dose ye-albuterol; Nangona kunjalo, ezi zifundo ziphakamisa ukuba kuphela enye yesine yedaysi ye-albuterol yayifunekayo ukuphumeza umphumo ofanayo xa usebenzisa i-Xopenex.
Oku bekucingelwa ukuba kungenxa yokungahambi kwe-S-albuterol isomerom e-Xopenex, eyayisebenza kunye ne-R-albuterol isomerom.
Idatha yakamuva kwi-Xopenex, nangona kunjalo, kunye nokujonga ngokubanzi yonke idatha ekhoyo, ibonisa ukuba i-Xopenex ayilunganga ngokuphatha i-asthma kunokuba ilindeleke. I-dose ye-Xopenex efunekayo ukufezekisa umphumo ofanayo wokuphatha i-asthma ibonakala ibe malunga nesiqingatha, oko kukulindelwe kuba iqulethe umsetyenzana osebenzayo (R-albuterol). I-S-albuterol isomerom ibonakala ikhutshwe, nto leyo ithetha ukuba ayenzi okanye ayilwe unyango lweempawu ze-asthma.
Ngaba i-Xopenex ingabikho miphumo embalwa ngaphandle kweAluteruter?
I-Albuterol yaziwa ngokubangela ukuba iziphumo ezithile zecala, kubandakanywa ukuthuthumela kwemisipha, ukuzithela, ukubethelwa kweentlungu kunye nokwanda kwentliziyo. Izifundo zakuqala ze-Xopenex zicebise ukuba kuba kufuneka ukuba unyango oluncinci lube lufunekayo ukuze kuzuze inzuzo efanayo njenge-albuterol, ziza kuba neziphumo ezimbi ezimbalwa. Ukongeza, okokuqala kwakucingwa ukuba i-S-albuterol isomerom yayiyiyona nto inoxanduva lwemiphumela emibi ye- albuterol, kwaye ngenxa yoko i-Xopenex, engenayo i-S-albuterol isomerom, ingaba nemiphumo emibini emibi.
Uphando olutshanje luchaza ukuba kunjalo, ukuba iziphumo zecala le-Xopenex zilingana ne-albuterol kuba ingumdlali we-R-albuterol ochaphazelekayo.
I-S-albuterol isomerom isingeniso, esithetha ukuba ayinxaxheba kwimiphumo emibi. Ingeniso ye-Xopenex ithi ireyithi yeziphumo zecandelo ezikhankanyiweyo ngasentla zifana nezilinganiso ezilinganayo ze-Xopenex kunye ne-albuterol.
Funda indlela yokusebenzisa nokucoca i-Xopenex inhaler .
Imithombo:
Ifayile ye-Xopenex [PDF]. Sepracor corporation. Kufike ngoJanuwari 13, 2011.
U-Ahrens R, Weinberger M. Levalbuterol kunye ne-Racemic Albuterol: Ngaba kukho ukungafani kokunyanga? J Allergy Clin Immunol. 2001; 108: 681-4.
UMilgrom H, uSkoner DP, uBensch G, et al. I-Low-Dose Levalbuterol kwaBantwana abane-Asthma: ukhuseleko kunye neZiko loLwazi ngokuthelekisa ne-Placebo kunye ne-Racemic Albuterol. J Allergy Clin Immunol. 2001; 108: 938-45.
ULötvall J, Palmqvist M, Arvidsson P, et al. Uhlobo lwe-R-Albuterol lwe-Therapeutic lufaniswa kunye ne-RS-Albuterol kwi-Asthmatic Patients. J Allergy Clin Immunol. 2001; 108: 681-4.