I-rim elayini ebomvu (i-RYR) isongezelelo sokutya esithengiswa njengomkhiqizo ongekho myalelo wokunciphisa i- cholesterol .
I-RYR isetyenzisiwe e-China iminyaka emibini ekuphekeni nasekuphatheni izifo zentsholongwane kunye nokutya. Nangona kunjalo, ekubeni isetyenziswe e-US ixesha elincinci kakhulu, liye ladala ingxabano enkulu.
Yintoni iRaven Yeast Rice?
I-RYR ngumkhiqizo welayisi owenziwe ngophula irayisi kunye ne- Monascus purpureus .
Iqulethe izinto ezininzi ezinokunciphisa amazinga e-cholesterol, kubandakanya i- beta-sterols , i- monounsaturated fatty acids , kunye ne- statin . Igama leekhemikhali yerenim ebonisa kwi-RYR yi-monocolin K, kodwa iyaziwa kangcono e-US njenge-lovastatin (ithengiswa njengeMevacor).
Ngaba i-RYR ephantsi kweCholesterol?
Ucwaningo luye lwabonisa ukuba i-RYR, njengokwenziwa ngokweShayina ngokwesiko kwaye ekuthengisweni kwangaphambili njengesongezelelo sokutya e-US, ngokwenene iyanciphisa ama- cholesterol ye-LDL .
Ngokomzekelo, kwizifundo ezingama-83 izigulane ezine-cholesterol eziphakamileyo, ezo zi-RYR zenzeke kakhulu ukunciphisa i-cholesterol (204 vs. 338 mg / dL) kunye ne-LDL i-cholesterol (128 vs. 277 mg / dL) emva kweveki ezi-8, kuthelekiswa nalabo bathatha indawo ye-placebo.
Ingxabano
Ingxabano, eqinisweni, kukuba i-RYR iqukethe i-statin eyenziwe ngokwemvelo. Izitatimende, ngokomthetho, ziziyobisi kwaye ngoko ziphantsi komgaqo.
Ingxabano yaqala ngo-1999, kungekudala emva kweemvavanyo zonyango kuqala kwabonisa ukuba i-RYR inokuba yinto ephantsi kakhulu ye-cholesterol. Ngelo xesha i-FDA yalawula ukuba i-RYR equkethe i-monocolin K yayiyilisisi, ngoko ke wayala ukuba isuswe kwi-shelves. Izigwebo ezithe zavela, kwaye (emva kokugweba okuphindaphindiweyo nangaphandle) kwi-10 ye-US Circuit Court yeziBheno zivunyelwene ne-FDA.
Ngoko, e-US, i-RYR isenokuthengiswa ngokusemthethweni, kodwa kuphela ukuba amanyathelo athatyathwa kwinkqubo yokuvelisa ukususa i-monocolin K.
I-RYR isasetyenziswa njengendleko yokutya, kwaye iveliswa ngabavelisi abaningana. Njengokuxhaswa kwezondlo, ukuqulunqwa kwayo kunye nomxholo akukabikho mthethweni. Kunzima kakhulu ukuba akunakwenzeka ukufumana ukuba umkhiqizo othile we-RYR uhleli kwi-shelf iqulethe.
Uphando
Ekubeni kukho konke ukudideka, izilingo ezimbini zeklinikhi zivele zibonisa ukuba kwithuba le-FDA, ubuncinane i-RYR efumanekayo e-US isebenzayo ekunciphiseni amazinga e-cholesterol.
Ngo-2009, isifundo esivela ePennsylvania sabonisa ukuba kwizigulane ezingama-60 ezayeka ukuthabatha izidakamizwa ze- statin ngenxa yesifo se-muscle intlungu , esithatha i-RYR kunye nokuqalisa utshintsho lwendlela yokuphila kwiiveki ezingama-24 ngokunciphisa kakhulu amanqanaba kunye ne-LDL ye-cholesterol, xa kuthelekiswa nokuthatha indawo ye-placebo kunye ukwenza indlela efanayo yokuphila.
Kwaye ngo-2010, uphando abavela kwiYunivesithi yasePennsylvania babika ukuba kwizigulane ezayeka ukuthabatha ama-statins ngenxa yobuhlungu be-muscle, i-RYR yayisebenza ngokufanayo njengama-20 mg ngosuku lwe-prainastatin ye-statin drug (Pravachol) ekunciphiseni amazinga e-cholesterol. (I-RYR kunye nePrachochol zivelise kuphela iziganeko eziphantsi kakhulu zentlungu ephindaphindiweyo.)
Kuphononongo luka-2009, abaphandi benza uhlalutyo lwamakhemikhali olusesikweni kwimveliso ye-RYR abayisebenzisayo ekufundeni (ukusuka eSyvan Bioproducts eKittanning, ePennsylvania). Bafumanise ukuba i-RYR ihlala iqulethe i-monacolin K kunye nezinye ezisibhozo ze-monacolin.
Isiphumo soluhlalutyo lwamachiza lubonisa izinto ezimbini. Okokuqala, ubuncinane i-RYR efumanekayo e-US ibonakala iqukethe enye i-lovastatin, kwaye yesibini, nangona ukuba yonke i-lovastatin isuswe ngokupheleleyo, ezinye iikhemikhali ezifanayo kwi-RYR (leyo i-FDA ayifumanekanga - kodwa ingeyona nto ikhutshwe ngokukodwa) inokusebenza ekunciphiseni i-cholesterol .
Ngaba kufuneka uthathe i-RYR?
Ekubeni ubuncinane, ukuthatha i-RYR kubonakala kuncinci ukuqwalaselwa ukuba ukhangele indlela engagunyazisiyo yokuchithwa kwe-cholesterol. Nangona kunjalo, into enokuyenza ngokwenene ithatha inani elingafaniyo nelingaziwayo lwezinto ezithile ezifana nesimo se-statin. Akunakwenzeka ukuxelela, ukusuka kumenzi ukuya kumenzi, okanye nakubhotile kwibhotile, into oyithengayo.
Ukuba ufuna ukunciphisa i-cholesterol yakho ngaphandle kokulahlekelwa yimikhono yakho kwiinkampani ezinkulu zeziyobisi, cela udokotela wakho malunga nezidakamizwa ze-statin. Zifumaneka ngokulula, ezincinci (mhlawumbi zithengisa ngaphezu kwe-RYR), kwaye njengobhonasi, i-dosage oyifumanayo iya kuthiwa yaziwa, kwaye ilawulwa kwaye ilungiswe ukulungiselela ukwandisa iziphumo zakho.
Imithombo:
Halbert SC, isiFrentshi B, uGordon RY, et al. Ukunyanzeliswa kwemvubelo ebomvu irayisi (i-2400 mg kabini imihla ngemihla) ngokubhekiselele kwi pravastatin (20 mg kabini imihla ngemihla) kwizigulane ezinokubandezeleka kwangaphambili komthetho. Ngaba uJ Cardiol 2010; 105: 198-204.
Becker DJ, Gordon RY, Halbert SC, et al. Isidlo esilomvu ilayisi ye-dyslipidemia kwizigulane ezingenakubekezela. Ann Internal Med 2009; 150: 830-839.
UGordon RY, Cooperman T, Obermeyer W, Becker DJ. Ukuchithwa kwamanqanaba e-monacolin kwimigqomo ebomvu yokuthengisa iirayisi: umthengi uqaphele! Arch Intern Med 2010; 170: 1722.