Ukunyuka kwamehlo okunyameka kwimilo yokulala yokulala kunye ne-melatonin
REM (ukunyamekela kwamehlo ngokukhawuleza) iingxaki zokuziphatha zokulala ziyakucasula ukuba akunakungozi kwaye ziye zaphazamisa ukunyanga. Yintoni esiyifundile ngendima ye-supplementary melatonin ekuphatheni le ngxaki?
Iingxaki zokuziphatha ze-REM (RBD)
Awunakuva malunga neengxaki zokuziphatha ze-REM (i-RBDs) , kodwa abantu abaninzi bayaziqhelanisa neminye imizekelo eqhelekileyo.
Ukuba uyayazi ngomntu ophuphayo ngokuhlaselwa ngumntu okanye isilwanyana aze avuke ahlume umyeni wakhe, uvile umzekelo. Ukuba wena okanye umntu owaziyo uye waphumelela ngenxa yamaphupha akho (ngelixa elele), inokuba yimeko eyaziwa njengeRBD.
Ukulala kunye neRBD
Ngexesha lobusuku obuqhelekileyo bokulala, sihamba ngeendlela ezahlukeneyo zokulala. Ukulala kwe-REM (kunye ne-REM imele ukulala ngokukhawuleza kwamehlo okulala) ingqondo iyasebenza. Yile nqanaba lokulala edla ngokudibanisa namaphupha. Ngexesha lokulala kwe-REM sisinakukwazi ukusebenzisa izihlunu zethu, ngaphandle kwemisipha yamehlo kunye nenkohliso yethu (ngoko siqhubeka siphefumula). Ukuba ezinye izihlunu zethu zikhubazekile ngeli hlobo lokulala, sinokukwazi ukuphumeza amaphupha ethu. Ezi ntshukumo zibhekiswa njengengxaki yokuziphatha kwe-REM.
Uninzi lwabantu banama-sleep sleep REM malunga nayo yonke imizuzu engama-90. Ekuqaleni ngobusuku obuqhelekileyo ulele ezi zihlandlo zifutshane kodwa zihamba ngokukhawuleza njengoko sisondela ekuvuseni kusasa.
Ubuthongo obuninzi be-REM bubonakala kwisithathu sokugqibela sokulala ebusuku.
I-REM evamile yokuLawula iziDaba
Ngelishwa, ininzi lamaphupha ahambelana neRBD ayamnandi kwaye aquka ukungena okanye ukuhlaselwa kwindlela ethile. Xa la maphupha aguqulelwa kwizenzo, ukuziphatha kunokubandakanya ukubetha, ukukhaba, ukulala ebhedeni, ukuthetha, okanye ukukhala.
Xa ezi ntshukumo zenzeka zingabangela ukulimala kumntu ofumana i-RBD okanye amaqabane abo elala. I-RBD ichaphazela abantu abayi-1 kwabangama-200 kwaye ixhaphake kakhulu kwindoda eneminyaka ephakathi, idibene nesifo se-Parkinson kunye nezinye iimeko ze-neurological, kunye nokurhoxiswa kotywala, kwaye kuya kwenzeka njengempembelelo engafanelekanga kwimithi enjenge-anti-depressants. Kuye kwabonwa kubantu abancinci abaneenqanawa .
I-RBD ingaba yingozi. Kwisifundo esithile, abantu abangama-32 ukuya kuma-64 ekhulwini abantu abajongene ne-RBD babangela ukulimala kwabo okanye abo balala nabo. Kwipesenti ezi-7 ezi zibandakanya amathambo aphukile. Nqabile kakhulu, i-RBD ibangele ukukratshi okanye ukulimala kwengqondo ebuhlungu. Nangona ukulimala kolukhulu kunjalo, nangona iRBD ngaphandle kokulimala kunokubangela uxinzelelo olukhulu kumntu ochaphazelekayo kunye nomlingane wabo olala.
Melatonin kunye noButhongo
I-Melatonin yi-hormone eyenziwa ngokwemvelo ekhoyo kwi-counter-counter. Isetyenziswe ngokubanzi ukusetyenziswa kweengxaki zengqungquthela ye-circumcadian , iingxaki zokulala ezingabonakaliyo, i-jet lag, kunye neempawu ze-menopausal. Kuye kuphandwa ngefuthe layo kwi- Alzheimer's disease , kwaye nangenxa yokukwazi ukukhusela nokuphatha umhlaza .
I-Melatonin ikhiqizwa ngokwemvelo kwintsipho yepineal yengqondo ngexesha lokulala. Amanqanaba amakhulu afihliwe ebumnyameni kwaye le sizathu esivela kwisinconywa sokulala egumbini elimnyama kunye nezibane. Ukongeza ekukhanyeni ebusuku, ukugula kunye nobudala kunokunciphisa inani lemvelo elifihliweyo. Imfihlo yeSelatonin iqala ngokuhlwa kwaye iphakame phakathi kobusuku (phakathi kwe-2 no-4 ekuseni.)
Ngaba i-melatonin inendima engalindelekanga ekuphatheni ingxaki yokuziphatha kwe-REM (RBD) ?
Ukusebenza kweMelatonin kwi-REM Sleep Disorder's Disorders
I-Melatonin iye yaphanda indima yayo ekuphatheni i-RBD, kwaye ngokwenene, ngoku iphakanyiswe umgca wokuqala (phambi kwayo nayiphi na enye into) kunyango lwengxaki yokulala.
Kubonakala kunemiphumo ethe ngqo kwi-disorder kune-Klonopin (clonazepam), unyango lokuqala lonyango olucetyiswa ngaphambili. Akukho kuphela ukuba i-melatonin isebenza kangcono, ikhuselekile kwaye ibekezeleke ngakumbi kuneKlonopin.
Kwizifundo, i-melatonin ithintela ithoni ye-muscle ngexesha lokulala kwe-REM (abantu bathuthe ngaphantsi kweli nqanaba lokulala) oku kuthetha ukunciphisa amandla okwenza amaphupha. Oku kubonakala kwizifundo ezifumene ukuba i-melatonin icacisa ngokucacileyo ukuziphatha kwe-REM.
Ingqalelo kukuba i-melatonin esetyenziselwa ukuphatha i-RBD idla ngokuphakamileyo kunaleyo isetyenziswe njengobuncedo bokulala, kunye nama-3 mg ukuya kwi-12 mg esetyenziswe kwizifundo ezichazwe.
Ukuxhaswa kweMelatonin kubonakala kuphumelele kubantu abane- Parkinson isifo , i-Lewy yokugula komzimba, kunye ne- multiple -roxy-atrophy- imeko ehlala ihlala kunye neRBD.
I-Melatonin Isebenza Njani Ukuphatha I-RBD kunye Neengxaki Zokulala?
Nangona ukuphumelela kwayo ekunciphiseni izifo zokuziphatha kwe-REM, asiqinisekanga ngokupheleleyo ukuba i-melatonin isebenza njani. I-Melatonin ibonakala iyimpawu emizimbeni yethu edibanisa ubuthongo bethu nokuvuka kwiipatheni zokukhanya kunye nomnyama kwindawo yethu.
I-Melatonin inokunceda ukuvumelanisa iindlela zokulala ukukhuthaza ubuthongo. Kwakhona kubonakala kukuphucula ukuphumelela kokulala. Kwinqanaba le-molecular, GABAergic inhibition (ukuvinjelwa kwesinye seengxaki ze-brain in the brain) inokudlala indima.
Inzuzo yeMelatonin
Enye yeenzuzo ezinkulu zokusetyenziswa kwe-melatonin kukuba ineziphumo ezimbalwa zecala. Xa kuthelekiswa neKlonopin, i-melatonin ineempembelelo ezimbalwa. Kwakhona kuncinci ukusebenzisana namanye amayeza umntu athabathayo.
Iingxaki kunye neempembelelo ezingeMelatonin
Njengoko kuphawuliwe kwangaphambili, izilingo ze-melatonin ezisetyenziswe kwizifundo ezivandlakisayo ukusetyenziswa kwazo kwiingxaki zokuziphatha kwe-REM ziye zaphakama kunezo ezisetyenziselwa ukulahla okanye i-jet lag. Iziphumo eziqhelekileyo ezichaphazelekayo ezifumaneka kwezi ziko zibandakanya ukulala kwasekuseni (iipesenti ezingama-29), ukuxhalabisa ukucinga (iipesenti ezili-12), iingxaki zokulinganisela (iipesenti eziyi-8), isisongulu (8 ekhulwini) kunye nokungasebenzi kwezesondo (8 ekhulwini).
Ngaphantsi kwindlela yokusetyenziswa kweMelatonin kwi-REM Sleep Behavior Disorders
I-Melatonin ibonakala iyindlela ekhuselekileyo neyonyamezelayo yokunyanga kweengxaki zokuziphatha kwe-REM kuneKlonopin, nangona i-Klonopin iboniswe kakuhle ukuba isebenza kakuhle. I-Melatonin ibonakala iphinde isebenze kangcono, kwaye ifikelele kwimpembelelo yezinto ezingavumelekanga kunokuba nje ilawule iimpawu. Abantu abaninzi abanokufumana i-RBD baneminyaka engama-50 ubudala nangaphezulu, kunye nezinye iimeko zonyango, kwaye i-melatonin ayinakuncipha ukusebenzisana namanye amayeza kuneKlonopin. Ngokubanzi, ukusetyenziswa kwe-melatonin inikezela ngendlela efanelekileyo kunye nekhuselekileyo yokuphatha malunga neengxaki zentsholongwane yokunyameka kwimiba yokulala yokulala.
> Imithombo:
> Howell, M., kunye noChenk. I-Rapid Eye Movement Sleep Sleep Disorder. UpToDate . Ukuhlaziywa 07/24/17.
> McGrane, I., Leung, J., St Louis, E., noBeeve. Ulwaphulo lwe-Melatonin lwe-REM Sleep Disorder Disorder: Uhlolo oluBalulekileyo lobungqina. U kulala kweMithi . 2015. 16 (1): 19-26.