Ukufunda kwinqanaba kukubonisa ukuba kungenzeka ukuba i-calcitonin njengonyango lwe-osteoarthritis.
I-Osteoarthritis ichaphazela abantu abayizigidi ezingama-21 e-United States, elilinganiselwa kuma-10 ekhulwini labantu abadala baseMerika. I-osteoarthritis zonyango zijolise ekulawuleni intlungu ehambelana nokulahlekelwa kwe-articular cartilage, i-subchondral sclerosis, kunye nokwakhiwa kwe- osteophytes . Akukho nkunkuma okanye unyango olwakwazi ukujolisa kwinkqubo yokutshatyalaliswa kunye.
Isiza esetyenziswa ngokubanzi ekuphatheni isifo sePaget sesithambo kunye ne- osteoporosis sinokukwazi ukuphuza okanye ukulwa nomonakalo we-cartilage. Yiyo abaphandi abayifunayo. Isilwayo yi-calcitonin kwaye i-hormone yama-amino acid eyenziwa yi- thyroid . I-Calcitonin inqunywe njenge-spray okanye i-injection.
Isifundo seCalcitonin kumaRats amabhinqa
Abaphandi bazama ukugqiba ukuba i-calcitonin ingaba isilwanyana esisetshenziselwa ukunyanga i-osteoarthritis. Uphando olutshanje lwamagqabi amabhinqa avumela abaphandi ukuba bagqibe ukuba i-calcitonin inokukhusela abafazi be-postmenopausal kwiintlungu eziqhubekayo kunye nokukhubazeka ezibophelelwe ekubhujisweni.
Olu pho nonongo lujoliswe kwiirati ze-ovariectomized, eziphethwe ngabaphandi ngokuxhomekeka komntu. Ukulahlekelwa kwe-estrogen kuye kwadibaniswa nokuthotywa kwe-cartilage. Esi sifundo kwakukho amaqela okufunda ama-5. Kwakukho amagumbi ayenayo:
- ovariectomy
- i-ovariectomy kunye ne-60-day release ye-estrogen pellet efakwe
- i-ovariectomy kunye ne-2 mg / kg ye-calcumonin ye-salum kunye ne-5CNAC (i-arhente yokuhanjiswa)
- i-ovariectomy kunye ne-5CNAC
- inkqubo yehla
Iisampuli zegazi zithathwa ngezikhathi ukusuka kwiigundane kunye nesisindo somzimba sarekhodwa. Kwiiveki ezingama-9, iiliti zaxutywa kwaye zahlaziywa. Zonke iirati ze-ovariectomized zibonisa ubungqina bokukhahlazeka kwe-articular cartilage.
Ulwaphulo lwe-Estrogen luchasa ukunyuka kwezinga lokuthotywa. UCalciton wasebenza kangcono.
Izigqibo malunga neCalcitonin
Abaphengululi baphetha ngokuthi i-estrogen kunye ne-calcitonin ikhuselwe nxamnye ne-surface effects of knetilage cartilage. I-Calcitonin yasebenza kangcono ngokukhusela ngokupheleleyo imimiselo. Ukwelashwa kweCalitonin kunokuphikisana kokubili ukukhawuleza kwe-cartilage degradation kunye nokwanda kwimihlaba ephezulu. Izilingo ezizayo ziya kufuna ubungqina obuninzi.
Abanye abaphandi, ekuqwalaseleni impembelelo yeziphumo zophando kwi-osteoarthritis yabantu, bazibuza ukuba isiphumo se-calcitonin kwi-cartilage siyakuthintela kunokuthintela unyango, inenzuzo enkulu kunokwenzeka kwi-osteoarthritis yokuqala. Kufuneka kuqatshelwe ukuba izihlandlo ngezinye izilwanyana zihluleka ukuvelisa iziphumo ezithembisayo kubantu, kodwa ngeli nqanaba uphando lwe calcitonin lunikeza ithemba lokuba kukho ukhetho olutsha olusetyenziswa endleleni.
Umthombo:
Impembelelo ye-Oral Calcitonin kwi-Cartilage Ukuguquka kunye ne-Surface Erosion kwi-Rat Ratings. Arthritis & Rheumatism. Agasti 2007.