I-Epithelial ye-Ovarian Cancer, i-Germ Cell, kunye ne-Sex-Cord Stromal Markor Markers
Njengomdlavuza wesifo somhlaza, mhlawumbi ugijimela kwixesha elithi "abamakishi be-tumor." Kodwa oko kuthetha ukuthini?
Umdlavuza we-ovariya ubizwa ngokuba uvela kwi-ovary (okanye i-fallopian tubes kufuphi ne-ovary.) Kodwa kukho ezininzi iintlobo ezahlukeneyo zeeseli kwii- ovaries , kwaye nganye yezi ntlobo zinokuba ngumhlaza. Ezi iiseli zinemisebenzi eyahlukileyo kwaye zivelise izinto ezahlukeneyo zezinto eziphilayo.
Ezi zinto zingalinganiswa kwigazi kwaye zibizwa ngokuba ngabamakishi be-tumor.
Kutheni ukuba ugqirha wakho usebenza kwiMvavanyo yeMarrha yeMvavanyo yeGazi
Kwezinye iimeko, i-marker marker yinto eveliswa kuphela yiiseli ezingaqhelekanga. Nangona kunjalo, kwiimeko ezininzi, aba makishi baveliswa ngamanqanaba aphezulu ngokungavumelekanga njengoko iiseli zomhlaza zihlawulela kwiindawo ezahlukileyo zemishini yazo ye-biochemical. Oogqirha bajonga kwiimvumi ezivelisa ubuninzi bezinto ezi njengamathambo ukuvakalisa aba makishi. Ngokomzekelo, endaweni yokuthi umdlavuza we-ovari wenza i-CA-125 engapheliyo, bangathi umhlaza uchaza i- CA-125 .
Iintlobo zeeCancer Cancer
Kwimeko apho, oku kuthetha ukuba ugqirha wakho unokujonga igazi lakho ukuvavanya amanqaku e-tumor, ebonisa ukuba unjani umhlaza, okanye kamva, ukuba unyango lusebenza njani. Ngokuqhelekileyo, abamakishi be-tumor behla xa kunokwenzeka ukuba unyango luphumelele.
Umdlavuza oqhelekileyo ovary ubizwa ngokuba ngumhlaza we-ovarian epithelial. Kukho ama-subtypes amathathu: i-mucinous, serous ne-endometrioid. Iintlobo ezinqabileyo ezinomdlavuza we-ovari zibizwa ngokuba yi-germ cell kunye nentambo yesondo. Ngalunye lwala manani amanqaku amaninzi, kodwa a makhankanye ayenye kwiqela ngalinye elikhulu.
Ama-Marker Tumor Markers Epithelial
Uvavanyo lwegazi lwe-CA-125 lwe-tumor luphawu oluqhelekileyo olusetyenziswe kweli qela leekomhlaza. I-CA imele "umhlaza we-antigen." I-CA-125 ingenziwa ngeeseli eziqhelekileyo kodwa zenziwe kwixininiso ephezulu kwezinye iiseli zomhlaza ze-ovariya kuneeseli eziqhelekileyo ze-ovarian.
I-CA-125 ingasetyenziselwa njengenxalenye yenkcazo yomngcipheko we-ovarian ukuba uhlolisise umdlavuza we-ovari, okanye ungasetyenziselwa ukubeka esweni impendulo kumanyango omhlaza we-ovari. Hayizo zonke i-ovarian cancers ezibonisa i-CA-125, kwaye amanqanaba aqhelekileyo kwi-20% yale hlobo yeentsholongwane ze-ovari. Ngokwahlukileyo, ezinye izicubu ze-ovarian ezinobungozi, kunye nezinye iimeko, zingakhokelela kwizinga eliphezulu le-CA-125.
Kwi-3 subtypes yomdlavuza we-ovarian epithelial, i-cancer ye-mucinous ayinakukwazi ukubonisa i-CA-125 kunokuba i-serous okanye i-endometrioid tumors.
I-HE4 - ipropiyini ye-epididymis yoluntu 4 isalathisi esitsha esitsha esingaba nesifo somhlaza we-ovari, kwaye kufana ne-CA-125 inokuthi ifumaneke kunye nezicubu ze-serous and endometrioid. Abanye abaphandi baye bafumanisa ukuba ukusebenzisa i-CA-125 kunye ne-HE4 kunceda kakhulu ekuhloleni umdlavuza we-ovari ngaphezu kokuvavanywa kusetyenziswa yodwa.
Ekubeni abafazi abangaphantsi kweminyaka engama-40 banamathuba amaninzi okuba nomdlavuza we-epithelial ovarian cancer, ezi zi-2 marker tumor zingaba luncedo kakhulu kwinkqubo yokuxilongwa kwabasetyhini abaselula.
Ezinye iimpawu zeentlungu ezinokuthi zisebenzise ukujonga iliso le-ovarian cancer, i- CA-72-4, CA-19-9 kunye ne- CEA (i-carcinoembryonic antigen). Kukho ezinye ezinokuphakanyiswa kodwa zingaphantsi kakhulu zisetyenziswa. I-CA 19-9 iyafumaneka kubasetyhini kunye ne-subtype ye-mucinous kwaye ingaba luncedo kwinkqubo yokuxilongwa xa idibene ne-CA-125.
Amakhwala e-Germ-Cell
Amanqaku amabini aphezulu asetyenziselwa eli qela leekhensi: iprotheni ye-alpha-protein (AFP) kunye ne-chorionic gonadotropin (hCG) . Le ndlela yokugqibela isetyenziselwa ukuqapha ukukhulelwa okuqhelekileyo. Amanqanaba e-AFP kunye ne-hCG ephakamileyo kakhulu yindlela ekhethekileyo yokufumanisa ezi zicubu.
Intambo yesondo-I-Stromal Markor Markers
Abamakishi kuphela kulolu hlobo luncedo luveliswa yi-granulosa cell subtype. Ezi ziquka i- estradiol (uhlobo lwe-estrogen) kunye ne- inhibin . Ekubeni ezi zihlamba zifumaneka rhoqo kubasetyhini abaselula , ezi mvavanyo zingenziwa njengenxalenye yokugqithisa kwesisu esiswini (kunye nezinye iimpawu ezinjengobuqhetseba obudala) kumantombazana kunye nabasetyhini abaselula.
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