I-rheumatoid arthritis , isifo esizimeleyo esichaphazela i-1.3 ukuya kwi-1.5 yezigidi zabantu baseMerika, sisiphumo samasosha omzimba omzimba ahlasele i-cartilage kunye namalungu. Yintoni eyenza u-haywire kwisistim somzimba somzimba womntu one-arthritis ye-rheumatoid ukudala intlungu kunye nentshabalalo ehambelana nesi sifo?
Izifundo ezenziwa nguDkt. Julia Ying Wang weBrigham & Isibhedlele sabafazi eBoston naseHarvard Medical School, kunye nomlingani wakhe uDkt Michael H.
I-Roehrl yaseHarvard, yaboniswa kwingqungquthela yonyaka ye-American Chemical Society ngo-Agasti 2002 kwaye yanyatheliswa kwi- PNAS, ukujongana nalo mbuzo.
Ngaphambi komsebenzi weWang noRoehrl, uphando lwe-rheumatoid ye-arthritis lujolise kakhulu kwiipepptides, okanye iinqununu zeprotheni. U-Wang noRohrl bacebisa ukuba i-glycosaminoglycans, okanye i-GAGs, yintoni ebangela i-rhyumineid arthritis kunokuba iiprotheni.
I-GAGs Theory
I-Glycosaminoglycans i-carbohydrates eyenziwa ngokwemvelo efumaneka kwi- cartilage , izicubu ezinxulumene kunye, kunye nolusu. I-Glycosaminoglycans zincome i-carbohydrate. Abachaphazelekayo ngama-carbohydrate, ama-starches, kunye noshukela esidlayo kwisondlo sethu.
Ngokucacileyo, iincwadana zikaWang zacetyiswa ukuba amajoni omzimba omzimba, okanye iintsholongwane, zijolise kwi-glycosaminoglycans. Ama-antibodies aphephe kwi-GAGs, aqokelele kumalungu, kwaye aqalise ubuhlungu kunye nokuvuvukala okunxulumene nesifo se-rheumatoid arthritis.
Uphando
Kwisifundo seWang noRohrl, iigundane zazifakwe kwi-GAGs.
Iigundane zavelisa izifo ezinjenge-arthritis ezinjenge-symptom, ezifana nokuvuvukala, ukuvuvukala, kunye nethambo.
I-Glycosaminoglycan antibodies eziye zafunyanwa kwiisisu zezigulane ze-rheumatoid arthritis. Kufuneka kugxininiswe ukuba le yithuba lokuqala i-glycosaminoglycan antibodies eye yabonwa kwizilwanyana okanye kubantu.
Abaphengululi bathi:
- Ama-anti-gag anti-GAG angakhula njengesiphumo sosulelo lwebhaktheriya.
- Amanqanaba aphezulu e-GAG anokubangela ukuba iibhaktheriya zivelise i-enzymes ezidibanisa izicubu ezixhamlayo kunye nokukhulula i-carbohydrate.
- Iibhaktheriya ezininzi zineGAG kwiseli yazo. Kwi-rheumatoid arthritis, amangqamuzana omzimba angakwazi ukujolisa ngephutha nge-GAGs ngokwemvelo kwiisisu zomzimba ngendlela efanayo abaza kujolisa ngayo i-GAG ebusweni be-bacterial invaders.
Abaphandi banethemba lokuba ezinye izifundo ziza kubonisa indlela yokubopha i-anti-gag anti-GAG, ekhokelela kwiindlela ezintsha okanye unyango lwe-rheumatoid arthritis. Uphando olupapashwe ngo-2008, kwi- Arthritis Research & Therapy , luchaze ngakumbi ngeGAGS:
- I-GAG-specific antibodies ayikho kwi-neonates (iintsana).
- I-GAG ikhona kwixabiso eliphezulu kwi-serum yabantu abadala.
- I-GAG ziye zahlulwa njengama-antigens e-TI2. I-cell B1 B ziyaziwa ukuba zisebenza ngokutsha kunye nama-antigens e-TI2.
Kwakhona kwaveliswa kwakhona ukuba izixhobo zokulwa ne-GAG ziyi-autoantibodies zendalo ezifumaneka kubantu abaphilileyo. Ama-antibodies aseGG anti-GAG kunye namanye ama-anti-gag anti-GAG ahlolwayo afunyenwe aphakanyisiwe kakhulu kwi-policy yezigulane ezine-rheumatoid arthritis. Nangona i-anti-GAG antibodies yayikho kwi-systemic circulation, i-synovial fluid kwaye nayo iyakwazi ukubophelela kumatrix esecalaslular ye-hyaline cartilage.
Abaphengululi bacinga ukuba imveliso ye-anti-GAG ye-antibody is "up-regulated" kwi-rheumatoid arthritis mhlawumbi inxulumene nokukhululwa kwee-molecule ze-cartilage. Okuthakazelisayo, amanqanaba aphezulu anxamnye ne-GAG adibaniswa nomsebenzi wesifo obuncinane kwisifo se-rheumatoid arthritis. Abaphengululi baphetha ukuba i-GAG ingaba yintsholongwane yesifo sokuqala yesifo se-rheumatoid arthritis.
Imithombo:
I-Glycosaminoglycans Ingabangela Ingxaki ye-Rheumatoid Arthritis. Iinkqubo ze-National Academy of Science ze-United States of America. Wang JY noRohrhr MH. Oktobha 21, 2002.
I-Autoantibodies zemvelo Isebenza kunye ne-Glycosaminoglycans kwi-Rheumatoid Arthritis. Bence Gyorgy et al. Uphando lwe-arthritis kunye neyeza. 2008.