Ingaba ixhomekeke kwi-lymphoma?
UPaul Langerhans wazalelwa eBerlin, eJamani, ngoJulayi 25,1847, unyana wegulane waseJamani. Ukuya kufunda isicatshulwa njengoyise, omncinci wenza into ebalulekileyo ngelixa esengumfundi ophantsi. Ukufumanisa kwakhe yinto eyaziwa ngokuba yii-epidermal cell Langerhans, eziyimphambili ebalulekileyo kwiimeko ezibizwa ngokuba yiLangerhans cell hertiocytosis.
Ukufumanisa iLangerhans iiseli zeDendritic
I-Langerhans ithatha inxaxheba kumncintiswano ovulekileyo ohlelwe yiYunivesithi yaseBerlin. Ingcali yenzululwazi egama linguJulius Cohnheim sele isetyenzisiwe indlela yokujonga izibilini zisebenzisa i-stain ekhethekileyo yegolide kunye ne-microscopy elula.
Ukusebenzisa iindlela zeColnheim zegolide ze-chloride ngo-1868, iiLangerhans ziboniswe kwaye zachaza into ekhumbeni eyayingafani nezinye iiseli zesikhumba-wayichaza njengento ye-dendritic kuba yayinamagatsha afana nomthi; kodwa wabuye wathi kwakungeyona i-pigmentary. Ngamanye amazwi, ayifumananga ne-melanin ye-pigment ekhoyo kwezinye iiseli ezibizwa ngokuthi i-melanocytes, ezibuye zixutywe, kwaye iiseli ezivela kuyo i- melanoma .
Ngelo xesha, wachaza le nxalenye ye-branching ye-branching yayiyihlobo oluthile lokufumana isalathiso kwesikhumba kwinkqubo yenzwa. Ngaphezu kwekhulu leminyaka kamva, izazinzulu ziya kufunda ukuba iLangerhans iiseli zesikhumba zinemisebenzi ebalulekileyo kwi- immune system .
Ngowe-1973, uDkt. Inga Silberberg wafumanisa ukuba iiseli ze-Langerhans ze-epidermal zimelela "inqwelomoya yecandelo lomzimba." Namhlanje, iiseli zeLangerhans zibhekwa njengengqamana yentsapho yamaseli e-dendritic, kwaye i-subset efundwa kakuhle kakhulu.
Iiseli zeLangerhans ezifunyenwe elukhumbeni zicatshangelwa ukuba zibe njengezisele ze-antigen ezikhoyo.
Ama-antigens ayinxalenye yeselula 'yeeteks' ukuba i-immune system iyakwazi ukuyiqonda. Ii-cell ezithengisa i-Antigen (APCs) ziiseli ezizenzekelayo ekuthatheni ama-antigens, ukuzicwangcisa, nokuzibonisa ngendlela ekhethekileyo ukuze ezinye iiseli ze-immune zingacetyiswa phambi kwe-antigen yangaphandle. Ngosizo lwe-APC, iiseli zegazi ezimhlophe zine-lymphocyte ziyakwazi ukuqonda nokuphendula kwiimpawu ezincinci kunye nabanye abahlaseli.
Iimpawu zeLangerhans Cell Histiocytosis (LCH)
I-Langerhans cell cell histiocytosis, okanye i-LCH, ikhethwa kwixesha elide, "i-histiocytosis X," kodwa zombini amagama abonakala kwiincwadi zonyango. I-LCH ngokwenene iqela lezifo ezinokukhula okungalawulwa ngokungalawulwayo kweeseli ze-Langerhans. Iyakwenzeka nanini na ubudala, nangona kungabonakali kubantu abadala. Nangona i-LCH yaziwa malunga nekhulu leminyaka, izazinzulu aziyiqondi zonke iinkcukacha malunga noko kubangela ukuba kwenzeke.
I-LCH ixhaphake ngokuqhelekileyo kunye nomntu oyedwa okanye "okhunjulwayo" ebonakalayo kwimimandla yokulahleka kwethambo kwi-imaging scans-kwiindawo apho, xa zixutywe, zibonisa ukuba ithambo ithatyathelwe yi-histiocytes eneenuclei ezinobumba.
I-Histiocytes, njengama-macrophage okanye iiseli ezithembekileyo, zinamajoni omzimba okutshabalalisa izinto zangaphandle kwizame zokukhusela umzimba kwiintsholongwane.
Ezi i-hertiocytes, kunye ne-lymphocytes, macrophages kunye ne-eosinophil, zingangena malunga nendawo yonke kodwa ingakumbi isikhumba, i-lymph nodes, imiphunga, i-thymus, isibindi, i-spleen, i-bone marrow, okanye inkqubo ye-nervous central.
Yintoni enokuyenza ngeLymphoma?
Ezinye iingcali zichaza ukuba i-LCH ingaba ukukhula okusebenzayo kweeseli zeLangerhans emva kwe-chemotherapy okanye i-radiotherapy yesifo sikaHodgkin. Le ngenye yeengcamango ezininzi.
Inani lamatyala e-Langerhans 'cell hertiocytosis ehambelana neliyo lymphoma elibi libikwe ngaphambili. Nangona kunjalo, iziganeko ezithe zenzeka, zenzeke nge - lymphoma ebulalayo, kunye nokulandela i-lymphoma.
I-LCH ixhaphake kakhulu kubantwana ukusuka kwinye ukuya kweyiminyaka emithathu ubudala, enokuzwakala ingethusa, kodwa khumbula ukuba i-LCH ayidlangalaleni.
Iimpawu zixhomekeke kwiindawo zokubandakanyeka kwaye isifo sinqunyanyiswe kwinkqubo enye-njengethambo, ngokomzekelo, malunga nesiqingatha samatyala. Ngamanye amaxesha ukuhlasela kwethambo akuvelanga iimpawu, kodwa ngamanye amaxesha kunokubakho intlungu kwindawo yendawo yethambo. Ukubandakanyeka kwesikhumba kubonakala malunga neepesenti ezingama-40 zeemeko, kwaye uphawu olugqithiseleyo lolusu luhlobo lwe-eczema-like like an infection.
I-LCH ingaba nzima ukuyixilonga, kodwa khumbula ukuba ukutyelela rhoqo ugqirha wakho kunye nencoko evulekile kakhulu kwandisa amathuba okufumanisa ukuba into ayikho eqhelekileyo.
> Imithombo:
> Diapedia. I-Living Bookbook yeSifo sikashukela. Paul Langerhans.
> Jaitley S, i-Saraswathi T. I-Pathophysiology yeLangerhans Iiseli. Umbhalo we-Oral and Maxillofacial Pathology: JOMFP . 2012; 16 (2): 239-244.
> Langerhans P. Uber Die Nerven Der Menschlichenhaut. I-Archives ye-Pathological Anatomy 1868; 44: 325-37.
> Li X, Deng Q, Li YM. Umzekelo weLangerhans 'Cell Histiocytosis Elandela izifo zeHodgkin. I-Molecular and Clinical Oncology. 2016; 5 (1): 27-30.
> Satter EK, High WA. I-Langerhans Cell Histiocytosis: Ukuphononongwa kweziNcomo zangoku ze-Histiocyte Society. I-Dediatr Dermatol . 2008 Meyi-Juni. 25 (3): 291-5.