Sibanzi
Umntu kuthiwa unokubandakanyeka komnxeba wethambo okanye "i-lymphoma engavumelaniyo" xa iintlobo ezimbini ze-lymphoma zichongwa kumntu ofanayo kwiindawo ezimbini ezihlukeneyo emzimbeni.
Kwi- non-Hodgkin's lymphoma, okanye i-NHL , ukubandakanyeka komnxeba wethambo okungahambelaniyo kwenzeka ngokuqhelekileyo xa i-lymphoma enobudlova itholakala kwi-lymph node biopsy kodwa i-lymphoma ekhulayo okanye ekhula ngokukhawuleza ifumaneka kwi-bone marrow biopsy.
Iimpembelelo, ukuba zikhona, ngokubambisana kunye nokungahambelani kokubandakanyeka komnxeba wethambo kwi-lymphoma kubonakala kuxhomekeke kwiintlobo ze-lymphoma ezifunyenweyo kunye nesimo esongezelelweyo malunga nesi sifo. Ngokuqhelekileyo, ukuyiqinisa izigqibo ngokuphathelele ukuhlaselwa kwesiseko esisekelwe kumbandela ochanekileyo okanye odibeneyo wokubandakanyeka komnxeba kuyinselele kuba, kwiimeko ezininzi, ukupapashwa kwedatha oogqirha abathembele kuyo kunzima.
Ukubandakanywa kweMarrow Bone
Uninzi oludumileyo okanye olukhula ngokukhawuleza lwe-B-cell lymphomas lunokubandakanyeka komnxeba wethambo ngexesha lokuxilongwa. Ngokumalunga nokusabalalisa i-B-cell lymphoma enkulu (iDLBCL), oluhlobo olunefuthe lwe-non-Hodgkin's lymphoma , uphando oluninzi lubonisa ukuba kuphela i-10 ukuya kwe-15 ekhulwini yamatyala ekubandakanyekeni komnxeba xa kufunyanwe. Nangona kunjalo, ukuhlolwa komnatha wethambo kubalulekile.
Concordance and Discordance
Xa ukubandakanyeka komnxeba wethambo kwenzeka kwi-lymphoma engeyona i-Hodgkin, ngokuqhelekileyo imeko yokuba amangqamuzana omhlaza emnxeni wethambo afana nomhlaza wesifo efunyenwe kwezinye iisayithi, ezinjenge-lymph node-kwaye oku kwaziwa ngokuba yi- concordance .
Ukuxabana kubhekisela kwiimeko ze-lymphoma apho i- hertology , okanye iimpawu kunye nokubonakala kweeseli zomhlaza, zihluke ngeendlela ezibalulekileyo phakathi kwethambo lomongo kunye nezinye izayithi zokubandakanyeka.
- I-discordant ihluke kwi- composite , ebhekisela kwimimandla emibini okanye ehlukeneyo yamaseli e-lymphoma kwisampuli enye ye- lymph node.
- Ukuhlukana kwahluke kakhulu kwinguqulelo , ebhekisela kwi-lymphoma eqala ukukhula ngokukhawuleza okanye engadliyo kodwa ke iguquke ibe lymphoma enobudlova (ngokuqhelekileyo i-DLBCL) ngexesha lesi sifo. Inguqu ye-Richter ngumzekelo wenguqu equka i-lymphocytic leukemia engapheliyo eguqula i-DLBCL okanye i-Hodgkin lymphoma.
Uxilongo, unyango kunye nomphumo
Ayikho into eninzi yokuvumelana malunga neendlela ezininzi zokufumana i-lymphomas ezingaxhatshazwayo, indlela abaziphatha ngayo kwizonyango, okanye indlela engcono yokuphatha ngayo, ngelanga. Iinkcukacha zivela kwiimeko ezingatshatanga eziye zaxelwa kwiincwadi zenzululwazi kunye nezifundo ezincinci ezibukeka ngasemva ukuze zizame ukufumana iipatheni kunye nemibutho.
Ukubandakanyeka komnxeba weTrand Concordant kuye kwaxhamla kwiziganeko eziqhubekayo zokusinda kwizigulane ezine-lymphoma ze-follicular follicular. Ukufunyanwa kubangela ukuphucula kwisigaba se-Ann Arbor se-IV kwaye ke amanqaku aphezulu kwisalathiso esetyenziselwa ukuhlaziya, umlinganiselo we-FLIPI.
Ukubandakanyeka kwethambo lomnxeba okungaqondakaliyo kubonakala ngathi kuncinci phakathi kwama-lymphomas akhula ngokukhawuleza; Ukubandakanyeka ngokugqithisileyo kuye kwacatshangelwa ukuba kwenzeke kuma-40 ukuya kuma-70 ekhulwini kwezigulane ezine-lymphoma ye-follicular.
Ukubandakanyeka komnxeba wethambo olungabonakaliyo kwi-lymphoma yendawo engaphelelanga kubonakala ngathi kwakunjalo.
Ngaphantsi
Ngokubhaliweyo bombhali wenqaku le-2016 elipapashwe "kwiGazi" - elibizwa ngokuthi 'Ukubandakanyeka komnxeba ongenalwazi kwi-ldphoma engeyona iHodgkin,' - uphando olongezelelweyo luninzi lufunekayo ukuze ukwazi ukuthetha kangcono ukuba kukuphi ukuvumelanisa kunye nokudibanisa kuthetha ezininzi izigulane ezine-lymphoma.
- I-Concordant yomnkantso wethambo ebandakanyeka ne-DLBCL ibonakala ibonisa umphumo ogqithiseleyo kunye nokuqhubekayo kokuqhubekayo kokuphila xa kuqhathaniswa namatyala ngaphandle kokubandakanyeka komnxeba wethambo.
- Umnxeba ongenalwazi olubandakanyekayo kunye ne-indolent okanye ukukhula ngokukhawuleza kwe-B-cell lymphoma kwi-DLBCL esanda kufunyaniswa ayibonakali ithintela kakubi kwi-prognosis.
Kwaye, nangona i- FDG-PET yinto ewusizo ekuxilongeni kwe-concordant bone marrow inxaxheba kwi-DLBCL, mhlawumbi kuncinci kakhulu ekufumaneni ukubandakanyeka komnxeba we-bone.
Imithombo
UBrudno J, uTadmor T, uPittaluga S. Ukubandakanyeka komnxeba ongenalwazi kwi-non-Hodgkin lymphoma. Igazi. 2016; 127 (8): 965-70.
Merli M, Arcaini L, Boveri E, et al. Uvavanyo lokubandakanyeka komnxeba weengxowa kwi-lymphomas engekho iHodgkin: ukuthelekiswa phakathi kwe-histology kunye ne-cytometry yokuhamba. Eur J Haematol . 2010; 85 (5): 405-15.
Sehn LH, Scott DW, uChanabhai M, et al. Impembelelo yomnxeba we-bone kunye nokungahambelananga ukubandakanyeka kwisiphumo kwi-B-cell lymphoma enkulu ephathwe nge-R-CHOP. J Clin Oncol . 2011; 29 (11): 1452-7.