Isifo se-Parkinson senzeke xa ezinye iiseliti zeentsimbi (ezibizwa ngokuba yi-neurons) ezikwindawo ethile yengqondo yakho ziyeke ukusebenza kakuhle okanye ziyafa. Ngokuqhelekileyo le neurons zivelisa iikhemikhali ebalulekileyo yengqondo ebizwa ngokuthi i-dopamine, enceda ukulawula umsebenzi we-muscle.
Xa ungenayo i-dopamine eyaneleyo ngenxa yokuba la ma-neurons awayivelisi, awukwazi ukulawula okanye ukulawula ukunyakaza kwemizimba yakho ngokuqhelekileyo.
Kungenxa yokuba indawo yengqondo yakho enezindlu ze-neuron (i-brain region) eyaziwa ngokuba yi-substantia nigra) ayikwazi ukudlulisela izibonakaliso kwi-elandelayo ebizwa ngokuthi "isiteshi sokulayishwa" kwengqondo, i-corpus striatum.
Izifundo zibonise ukuba izigulane zikaParkinson zilahlekelwa ngama-80% okanye ngaphezulu kweeseli ezivelisa i-dopamine kwi-substantia nigra. Ukuntuleka kwe-dopamine kukhokelela ekuhambeni okunamandla, okunamandla okufumaneka kwisifo sikaParkinson.
Yintoni ebangela ukulahlekelwa kweDopamine e-Parkinson?
Oososayensi abazi ukuba kutheni amangqamuzana ebuchopho kwi-substantia nigra inxalenye yengqondo yakho yokuyeka ukwenza i-dopamine, kodwa kukho iingcamango ezininzi.
I-Genetics ingadlala indima kwezinye iimeko zesifo se-Parkinson. Abangama-15% ukuya kuma-25% abo bafumene i-Parkinson nabo banesihlobo esinesimo, esibonisa ukuba unxibelelwano lwezofuzo. Ukongezelela, kukho iintlobo ezithile zesifo se-Parkinson esisebenza kwiintsapho, kwaye ezinye zezinto eziphilayo ezibandakanyekileyo ziye zachongwa.
Kodwa abaninzi abantu abanesifo sika-Parkinson abonakala bengenayo imbali yentsapho eqinile kwimeko, kwaye ngoko abaphandi bajonga kwenye indawo ngenxa yeso sizathu.
Iingcamango kwi-Root Causes
Enye imbono ebandakanya ingcinezelo yesifo sika-Parkinson-ukutshatyalaliswa kweeseli zesigulane ezenza i-dopamine-igxininisa ukuba iiseli ziwonakaliswe ngenxa ye-ree radicals emzimbeni.
Ama-radicals amahhala azinzileyo, ama-molecule awonakalisa ayenziwe ngempembelelo eqhelekileyo emzimbeni.
Ama-radicals amahhala asabela ngama-molecule esondelene nawo (ingakumbi isinyithi ezifana nentsimbi) kwinkqubo ebizwa nge-oxidation. Ukucatshulwa kucatshangelwa ukuba kubangele izidakamizwa, kuquka neurons. Ngokuqhelekileyo, umonakalo omkhulu wamahhala ugcinwa phantsi kolawulo ngama-antioxidants, iikhemikhali ezikhusela iiseli kule monakalo.
Kuye kwafunyanwa abagulane nesifo se-Parkinson ukuba banyuke ubuninzi beengcingo, ikakhulukazi kwi-substantia nigra, kunye namazinga aphantsi e-ferritin, iprotheni efunyenwe emzimbeni ojikeleze isinyithi kwaye iyayihlukanisa, ngaloo ndlela ikhusele izicubu zomzimba kuyo.
Enye imbono iquka i-pesticides kunye nezinye iibhox. Ezinye izazinzulu ziye zaphakamisa ukuba isifo se-Parkinson sinokuvela xa i-toxin kwindawo yonakalisa i-neurons eyenza i-dopamine. Kukho inani leetekisi (1-methyl-4-phenyl-1,2,3,6, -tetrahydropyridine, okanye i-MPTP, enye) engabangela iimpawu zesifo se-Parkinson.
Kuze kube ngoku, akukho uphando olunike ubungqina obuqinileyo bokuthi i-toxin yimbangela yesifo.
Kanti enye ingcamango iphakamisa ukuba isifo sika-Parkinson senzeka xa, ngenxa yezizathu ezingaziwa, eziqhelekileyo, ezinxulumene nobudala be-neopon-producing neurons zikhawuleza kubantu abathile.
Le ngcamango ixhaswa ngcamango yokuba silahlekelwa ngokukhawuleza iinkqubo ezikhusela zethu i-neurons njengoko sibudala.
Abaphengululi abaninzi bakholelwa ukuba ukuhlanganiswa kwezi ndlela ezine - umonakalo ochithisayo , iibhoksi zendalo, i-genetic predisposition, kunye nokuguga-ngokukhawuleza kuboniswe ukuba kubangele isifo.
Imithombo:
Izifo zePasinson's Foundation. Ubangela umxholo wenkcazelo.
Izifo zePasinson's Foundation. Izinto zeNdalo kunye ne-Parkinson: Yintoni esiyifundayo? ishiti yeenyani.