Kukho ezimbini iindidi eziphambili ze-arthritis ezingapheliyo. Okokuqala, i- osteoarthritis , ngokuqhelekileyo kucatshangelwa ukuba yiphumo elingenakukuphepheka lokuguga kunye nokukhawulelana kunye nokuguga okanye emva kokulimala. Iyesibini yimizimba yesifo se-arthritis, esino-arthritis ye- rheumatoid (RA) . Kwi-RA, iiseli ze-immune system kunye nabathunywa babo abakhululwe (i-cytokines ngumzekelo omnye), hlasela izicubu ngaphakathi kwamalungu adala ukuvuvukala.
Zombini zinokubangela umonakalo odibeneyo kunye nokukhubazeka-kakhulu kangangokuthi kuchaphazela umgangatho wobomi bomntu. Kodwa ukuba unayo i-arthritis, mhlawumbi uyazi kakuhle loo nxalenye yokugqibela. Oko kungenakukwazi ukuba wena, nangona kunjalo, ukuba zombini iintlobo ze-arthritis zibandakanya into ebizwa ngokuba yi-oxidative stress in the joints-kwaye le nto ibangela umonakalo odibeneyo yinto enokuyichaphazela ngayo.
Ukuqonda ukuxinezeleka koxinzelelo
Uxinzelelo lwe-oxidative yinkqubo eqhelekileyo ephuma kumsebenzi wakho wemihla ngemihla. Njengoko iiseli zakho zenza umsebenzi wazo, zenza i-radicals ekhululekile, endiyicinga "njengentsha" okanye imililo encinane. Emva koko isistim somzimba wakho wokukhusela i-antioxidant siphume ngaphandle, kufana ne-hose yomlilo ephosa ilangatye.
Amanqanaba aphantsi okuxinzeleleka okwenkcenkceshe ngokwenene ancedo kwimisebenzi yakho yesiqhelo. Ngenxa yokucima i-radicals yamahhala yinkqubo eqhelekileyo, indalo isinike inqwaba yama-antioxidants ekudleni esikudlayo-izixhobo ezifunyenwe kwiziqhamo nemifuno-ezidibeneyo ezimelelwe yimifanekiso eqaqambileyo eyahlukahlukeneyo yale yokutya.
Nsuku zonke, ufanele udle ukutya okuxhatshazwayo ukuze unikeze umzimba wakho nge-antidote kula ma-radicals amahhala. Nangona kunjalo, ukuba ungenayo i-antioxidants ngokwaneleyo emzimbeni wakho ukuba uqhubeke kunye nazo zonke iintlanzi ezidalwa, ekugqibeleni i-radicals izakuphumelela, iintshaba ziba ngumlilo kwaye umlilo uvutha ukutshabalala, umonakalo wesisu, kwaye ekugqibeleni izifo.
Uxinzelelo lwe-oxidative lunokuchaphazela amangqamuzana omzimba wakho omzimba, ngokukodwa, kuba asebenzayo, kwaye adala kwaye akhululwe ama-radicals amahhala xa enza umsebenzi wabo wemihla ngemihla ukukhusela. Le yinkqubo esiyikholelwa ngayo i-RA kunye nezinye izifo ze-arthritis ezivuthayo, eziquka i-osteoarthritis, ithatha kwaye ikhula.
Ukuxhamla kwiArthritis
Inani elikhulu leengxelo liye lwabonisa ukuba abantu abane-RA banyukile amazinga eamolekyu ebizwa ngokuba yi-ROS), ama-radical ekhululekile anakho ukulimaza i-lipids, iiprotheni kunye ne-DNA kwiimpawu ezidibeneyo.
Kwiimeko eziqhelekileyo, i-ROS ilawulwa ziinkqubo ezahlukeneyo zokhuselo lomzimba wakho. Kuye abantu abane-RA, nangona kunjalo, i-antioxidants ayikwazi ukuqhubeka kwaye i-radicals yamahhala iyakwazi ukuqhuba i-amok kwaye ibangele umonakalo wesisu. Xa zidibaniswe nokuhlaselwa okuqhubekayo kumalungu akho nge-immune system yakho, eli nqanaba eliphezulu lexinzelelo lokuxhalabisa liqhubeka likhupha. Yonke inkqubo inokukhokelela ekutshatyalaliswa kwethambo, amajoyina kunye ne-cartilage.
Xa abaphandi be-Aligarh University yase-India eNdiya bafanisa uxinzelelo lwe-oxidative kubantu abaxilongwa ngu-RA kubantu abangenawo esi sifo, abaxhamli be-RA babenamaqondo aphezulu okuxinwa kwe-oxidative, kubandakanywa ukunyuka kwe-ROS, umonakalo we-DNA, iinkqubo ezingakhuselekanga zokukhusela i-antioxidant, kunye namanye amanqaku.
Babenamazinga aphantsi a-antioxidants: i-glutathione kunye ne-vitamin C. I-Glutathione mhlawumbi ibaluleke kakhulu kumzimba ngenxa yokuba isebenza ngaphakathi kuzo zonke iiseli zakho ukukhusela umzimba wakho kumonakalo weROS. Okuthakazelisayo kukuba, abagulayo abane-RA abanentlungu kunye nokukhubazeka kunye nabanikeze i-RA abaneminyaka ephakamileyo kunamaqondo aphezulu okuxinzelelo okuxhamla kunye namanqanaba aphantsi kwama-antioxidants. Izifundo zihlala zixhasana nale nxu lumano phakathi kwamanqanaba aphantsi ase-antioxidants kunye nokunyuka kwamanqaku e-radicals kumahhala kubantu abane-RA.
I-Osteoarthritis (OA) idibaniswe namazinga aphezulu okuxinzezeleka kwengcinezelo, nayo. Kukholelwa ukuba abantu abagqithiseleyo okanye abanamafutha omzimba angaphezu kwama-visceral (uhlobo lweoli ephakathi kwesisu sakho, ukugubungela ezithombeni zakho zangaphakathi) banokuxinzelela ngakumbi kwimizimba yabo, kwaye kukho ubudlelwane obuqinileyo phakathi kokukhuluphala no-OA.
Kukholelwa ukuba ukuqhutyelwa okuqhubekayo kuma-radicals amahhala kubangela i-chondrocytes (iiseli ezenza i-cartilage) ukuvelisa iintlobo ze-oksijeni ezisebenzayo (ROS), kwaye zonakalisa ngokukhawuleza i-cartilage i-collagen kwaye zitshintshe amanzi angaphakathi ngamalungu ngokuzenza zibe mncinci kwaye zingakhuseli. Izifundo zibonisa ukuba amazinga aphantsi a-vithamini C adibene nomngcipheko ophezulu weedolo u-OA kwaye ukwandisa ukungena kwakho kungagcina i-OA idolo kunye neentlungu zokuba zibi kakhulu. Iindaba ezilungileyo kukuba iingcaphephe zibonisa ukuba ukulahlekelwa ngamafutha omzimba kuya kubangela intlungu edibeneyo kunye nokuvuvukala.
Indlela onokuthatha ngayo isenzo
Ukusetyenziswa kokutya njengamayeza kuhlala kuyisinyathelo sokuqala ukunciphisa ukuvuvukala kunye nokuxinzezeleka kwengcinezelo. Nantsi sigxila ekuphuculeni umsebenzi we-antioxidant emzimbeni wakho. I-antioxidant system isebenzisa i-enzyme ezininzi ezahlukahlukeneyo zokulawula uxinzelelo lwe-oxidative, ezifana ne-superoxide dismutase (SOD), kwaye ezi zinyulu zifuna iivithamini, amaminerali kunye nama-amino acids ukuze benze umsebenzi wabo omhle.
Ukucima i-radicals yamahhala, i-antioxidants ekudleni nayo ibaluleke kakhulu, kwaye ezi ziquka amavithamini awaziwayo njenge-beta-carotene kunye namavithamini A, E, no-C, kwakunye ne-polyphenols yamandla eninzi ngokugqithiseleyo kwimifuno enombala kunye neziqhamo, kunye nemifuno eluhlaza kufuneka udla yonke imihla, kunye naso sonke isidlo.
Ukongezelela ekuphuculeni ukungenisa kwakho i-antioxidants, ukuguqula ngokwenene nokuphulukisa i-arthritis yakho, kufuneka uphinde ubhekane nokuchasana nokusingqongileyo kunye neziphumo ezinokuthi zongeze uxinzelelo lwe-oxidative kwinkqubo yakho. Ezi zixinzelelo ziquka gut dysbiosis (utshintsho kwi-microbiome), ukuchazwa kweetekisi, izifo, kunye / okanye amaninzi amaninzi.
Ukunyanga i-microbiome yegciwane kunye negalelo elidakalayo linomsebenzi osisiseko emva kwendlela yokusekela isifo se-arthritis kuba kubonakala ukuba ukuxinzezeleka kweengcinezelo kunye nokuvuvukala kuqalisa ukuqala kwaye uhambe kwiindawo ezikude zomzimba wakho, kubandakanywa namalungu akho.
Khumbula, i-arthritis yimeko ye-system-wide, kwaye intlungu ovakalelwa kukuba ibangelwa ukunyuka nokuxinzezeleka kokuxhamla kwamanye amazwe emzimbeni wakho. Ukuba ufumana kwaye uphatha umthombo, uya kuziva ungcono ngaphandle kweyeza. Yaye yinjongo.
UDkt. Blum ngumlobi we-"Healing Arthritis," echaza indlela yokuphilisa umthamo nokuphatha iziphumo zokuxinzezeleka kwengcinezelo (iScribner 2017).
> Imithombo:
> Hani M. Khojah, Sameh Ahmed, Mahran S. Abdel-Rahman, Al-Badr Hamza, i-oxygen esebenzayo kunye neentlobo ze-nitrogen kwizigulane ezine-arthritis ye-rheumato njengezixhobo ezinokuthi zisebenzise izifo kunye nenxaxheba yama-antioxidants. I-Biological Radical Biology kunye neMithi, uMqulu 97, ngo-Agasti 2016.
> Mateen S, Moin S, Khan AQ, Zafar A, Fatima N (2016) Ukwandiswa kohlobo lwe-oksijeni kunye noxinzelelo lwe-Oxidative kwi-Rheumatoid Arthritis. I-PLOS ONE 11 (4): e0152925. i-doi: 10.1371 / iphephandaba.pone.0152925
> Musumeci G, Aiello FC, Szychlinska MA, Di Rosa M, Castrogiovanni P, et al. (2015). I-Osteoarthritis ekhulwini lama-20 leminyaka: izinto ezinobungozi kunye neendlela > iimpawu zokuziphatha > ezichaphazela izifo eziza kuqala nokuqhubeka. International Journal of Molecular > Sciences, > 16 (3): 6093-112.
> I-Quiñonez-Flores CM, iGonzález-Chávez SA, i-Del Río Nájera D, i-Pacheco-Tena C. Ukuxinezeleka koxinzelelo kwiPathogenesis yeArthritis yeRumatoid: UkuHlola okuHlolo. BioMed Research International. 2016; 2016: 6097417. i-doi: 10.1155 / 2016/6097417