Iqela elitsha leKamva leMilly Sclerosis
Ukuba unesifo se-MS okanye unomntu othandekayo owenzayo, mhlawumbi uchithe ixesha elide ucinga, unqwenela, okanye uthandazela unyango olungcono, kwanokuba unyango. Iindaba ezilungileyo kukuba kukho inqwaba yeemvavanyo ze-MS ezifundiswayo ngoku, zombini ebhodini nakwiimvavanyo zeclini. Omnye othembisa ukuphulukiswa kwengqondo ngokuphambili kukuphuhliswa kwe-MS vaccine.
Ukwahlula i-MS Vaccine ukusuka kwezinye izitofu
Xa ucinga ngamagonyo, abaninzi bethu bacinga ngokukhupha iimakhono zethu ukuze sifumane umjovo oza kusithintela ukuba sifumane izifo ezinobungozi, ezinjengomkhuhlane, imasisi okanye i-rubella. Ezi zitofu ziqulethe iipilisi okanye iibhaktheriya ezibuthathaka okanye zibulewe ukuze zingasenza sigule ngokwenene, kodwa zikhohlise i-system yethu yokuzivikela ekukhuseleni impendulo.
Kodwa injongo yokugonywa kwe-MS ayiyi kuba ngumqobo. Kunoko, indlela yokwenza iya kuba yonyango. Oku kuthetha ukuba kuya kunikwa ukukhusela okanye ukunciphisa ubunzima beempawu ezinxulumene ne-MS kunye neengxaki zempilo kumntu osufumene ufumane i-MS.
Omnye umahluko phakathi kwegciwane lomdabu kunye nomviwa we-MS vaccine ukuba izitofu zendabuko zenzelwe ukukhusela isifo esithathelwanayo-oko kukuthi, isifo esibangelwa ukusuleleka nge-microorganisms zangaphandle, ezinjenge-virus okanye ibhaktheriya.
Nangona kunjalo, i-MS ayiyisifo esithathelwanayo. Kunoko, i-MS yisifo esizimele . Ngesizathu esithile, amajoni ethu omzimba ahlasele i- myelin kunye ne-nervous fibers kwiinkqubo zethu ezisemkhatsini . Ngamanye amagama, i-MS ibangelwa yinto ethile eyenziwa ngumzimba wethu ngokwayo, kwaye ingabangeli ngumhlaseli wangaphandle.
Ngoko, iinqununu zabaviwa be-MS vaccine ziyi-microorganisms kodwa ezinye izinto zenzelwe "ukuwubetha" amayeza ethu omzimba ngeendlela ezahlukeneyo zokumisa amangqamuzana ethu omzimba ekuhlaseleni ubuchopho kunye nentambo yomthambo.
Ziziphi ii-MS Vaccines Ukuba ZiSifundo?
Apha ahlukeneyo ahlukeneyo abaviwa be-MS abavavanywayo: Tcelna, NeuroVax, BHT-3009, kunye ne-RTL1000. Ngamanye kwezi zitofu zisebenzisa indlela eyahlukileyo yokufikelela umgomo walo wokuyeka umsebenzi wokuzimela ngokumelene ne-myelin.
I-Tcelna (eyayisakuba yi-Tovaxin): I- Tcelna-eyayibizwa ngokuba yi-Tovaxin-isitofu sokugonywa kwe-T-cell eyi-autologous, esithetha ukuba iqulethwe ngumntu we-myelin-reactive we -cells , abajongene nokuhlasela i-myelin kubantu abane-MS, ababuleweyo. Ngokufakela umthamo omkhulu waloo mva kumntu, i-Tovaxin ifumana isistim somzimba sokulwa nokutshabalalisa zonke ezinye iiseli zisasazwa ngaphandle kokuchaphazela onke amasosha omzimba.
Esi sifo sitholakale sikhuselekile kodwa asizange sinciphise kakhulu inani le-gadolinium-enhancing MS lesions kwisifundo sezigulane ezingama-150 ngo-2008. Ngoku sele sibhekene novavanyo olutsha lweklinikhi, olwenziwe ngo-2012 phantsi kwegama elithi Tcelna, ukuvavanya indima ekunciphiseni i-brain atrophy nokulibaziseka ukukhubazeka.
I-NeuroVax: I- NeuroVax yi-T-cell receptor ye-peptide vaccine, oku kuthetha ukuba yenziwe kwiziqwenga zeprotheni ezifana neengxenye ze-T-cell ezinama-pathogenic ezihlasela i-myelin. Yenzelwe ukuvuselela umzimba ukuba wenze ngaphezulu kwee-T-cell ezilawulayo ezilawula umsebenzi wee-pathogenic, okanye "ezibi" zeeseli ze-T.
I-Neurovax ifakwe kwisisipha rhoqo kwiiveki ezi-4. Izilingo zesigaba se-2 zezilwanyana zesifo se-sclerosis ezincinci ziqhubekile ngoku zikhutshwe kulolu hlobo lokugonya.
I-BHT-3009: Esi sitofu senziwe nge-DNA ye-genetically engineered DNA efana neprotheni e-myelin ukuba isifo sethu se-immune sihlasela, esibizwa ngokuba yi-myelin protein esiseko.
Injongo yalo kukudibanisa "utshintshi" olawula ukumelana nomzimba, ngokuqinisekileyo "ukuhlaziya" amaseli omzimba ahlasela i-myelin sheath kubantu abane-MS.
Ucwaningo lwezenzululwazi lubonisa ukuba ugonyo lukhuselekile kwaye lunyamezeleke kwaye luya kungena kwizilingo zesiganeko seSigaba III kungekudala.
I-RTL1000: "RTL" inokufutshane " yeelandi ze-T-cell receptor ligands," eziyi-proteins ezibophelela kwi-receptor yee-T-cell ezonakalisa i-myelin kubantu abane-MS. Ngokuzihlanganisa ezi zifunyenwe, i-T-seli ayisakwazi ukwenza umonakalo. Ezinye iingcali azifaki nalolu hlobo "kwiintlobo zokugonya" xa abanye benza.
I-RTL1000 ifunyenwe ikhuselekile kwaye ixhomekeke kakuhle njengokwenziwa komgaqo-ntliziyo olulodwa kwisigaba esincinci seSigaba se-1. Abaphandi bacwangcise ukuqhubela phambili ukuvavanya ukhuseleko kunye nokusebenza kwayo njengengxubevange yeenyanga nganye kwisivivinyo seSigaba sesi-2.
Intshumayelo Enomdla kwiMount Sclerosis
Ezi zitofu ezinokuthi zinike iininzi zithemba. Ewe, baqhubeka bevavanywa kwaye bekude ukuba bafumane ininzi lethu. Nangona kunjalo, bavuya gqitha. Cinga ngokuxoxa ngazo nodokotela wakho kwaye ulandele iilingo kwiNgcaciso yeMvavanyo yeCliniki .
Imithombo:
I-Correale J, uFarez M, i-Gilmore W. Iigonyamelo ze-sclerosis ezininzi: inkqubela phambili ukuya kumhla. CNS Iziyobisi. 2008; 22 (3): 175-98.
I-Correale J & Fiol M. BHT-3009, i-myelin iplasmid ye-protein-encode ye-protocol yokunyanga i-multiple sclerosis. Curr Opin Mol Ther . 2009 Aug; 11 (4): 463-70.
I-Multiple Sclerosis Association of America. (2013). Iimvavanyo zovavanyo: iTcelna (eyayisakuba yi-Tovaxin). Ibuyiswe ngoJanuwari 10th 2015.
I-Multiple Sclerosis Association of America. (2013). Imilinga yovavanyo: BHT-3009. Ibuyiswe ngoJanuwari 19th 2015.
Yadav V et al. I-Recipinant Re-Receptor Ligand (RTL) ekwenzeni unyango lwe-multiple sclerosis: I-double-blind-controlled, placebo-elawulwayo, isigaba 1, isifundo sokunyuka kwesantya. I-Disimune Dis . 2012; 2012: 954739.