I-Immune System Genes ixhunywe kwi-MS
Izaziso zakho ziyimfuneko ebalulekileyo ukuba okanye awukho engozini yokuphuhlisa i-MS , njengoko ixhaswa yizo zentsapho kunye nezifundo zesayensi.
Izifundo zoNtsapho njengobufakazi bokuthi iGenesis idlala indima e-MS
Kuwonkewonke, kukho ithuba eli-1 kwi-750 (iipesenti eziyi-0.1) ithuba lokuba umntu ahlakulele i-MS. Kodwa iwele elifanayo lomntu one-MS linamathuba angama-25 ukuya kwangu-40 amathuba okuphuhlisa i-MS, kwaye umntakwabo okanye umntwana womntu onama-MS unethuba elingama-3 ukuya kuma-5 ekhefu.
IiScientific Studies njengobufakazi bokuthi iGenesis idlala indima e-MS
Uphando olwenziwa ngo-2007 olupapashwe kwiNew England Journal of Medicine lufumene i-genetic risk factor for multiple sclerosis (MS). Uphononongo lubonisa ukuba abantu abanokuhlukahluka kwezinto ezimbini ezihlukeneyo ezibandakanyeka kwisistim sokuzivikela (i-IL7RA kunye ne-IL2RA) banakho amathuba okuba babe ne-MS kunabantu abangenazo izigulo.
I-IZ7RA ne-IL2RA ziiprotheni ezikhokela izenzo zenye i-cell cell (T cells). Njengoko iizakhi zilawula indlela iiprotheni ezenziwe ngayo emzimbeni, utshintsho kwimodi yeprotheni lubonisa umahluko kwimfuza.
Ingxelo ehlobene ne-MS yeprotheni inokuba negalelo kwi-MS ngokukhokela loo maseli omzimba ukuba ahlasele inkqubo ye-nervous, ekhokelela ekutshitshisweni kwamanzi kunye nezilonda kwi-brain kunye nomgogodla. Lo monakalo, kwakhona, ubangela iimpawu ezininzi ze- MS . Okuthakazelisayo, ukuguqulwa kwe-IL2R kuye kwadibaniswa nohlobo lwesifo sikashukela nesifo se-Graves, kunye nezifo ezizimelayo .
Ezinye iinkalo ziye zaxhasa unxibelelwano phakathi kwe-MS kunye namajethi alawulwa ngumzimba womzimba. Inxalenye ekhohlakeleyo kukuba kunokwenzeka ukuba kukho inani elikhulu lokuguquka kwemfuyo, kulinganiselwa ukuba ngu-50 ukuya ku-100 yi-National Society of MS, enokumisela umngcipheko womntu wokuphuhlisa i-MS kwaye ukuba ngaba bahlakulela i-MS, ukuba kunzima kangakanani.
Ukuhlalutya idatha ye-gene ye-MS iyanzima kwaye idla ixesha, kodwa kuxabiseke, ngakumbi ukuba ingaba bhetele ukulungelelanisa imithi ye-MS.
Okukwintsusa
Kubalulekile ukuqonda ukuba ngelixa iigesi zidlala indima ebalulekileyo ekuphuhlisweni kwe-MS kwaye mhlawumbi ikhosi iya kulandela, akuzona zonke izinto. Ngamanye amazwi, i- MS ayilona isifo esilungeleleneyo ngokuqinisekileyo, ngoko akukho siqinisekiso sokuthi uya kuthi okanye awuyi kuwufumana ngokusekelwe kwimbali yakho yentsapho (okanye ikhowudi yakho yofuzo).
Esikhundleni saloo ndlela, i-MS eqhubeka ngayo kwaye ibonakalise kumntu inzima, iquka ukuguqulwa phakathi kweendalo zomntu kunye nokusingqongileyo. Ngokomzekelo, uluhlu lweenguqu zemizimba lunokwenza umntu abe mngcipheko ekuphuhliseni i-MS xa ebonakaliswe kwindawo ethile yokusingqongileyo, njengentsholongwane (nangona, asazi ezo zimbangela ezicacileyo okwamanje).
Njengokuba kunjalo ngoku, oogqirha abazenzi ukuhlolwa kofuzo kubantu abane-MS okanye amalungu omndeni abo bane-MS. Kodwa njengephambili ye-MS yophando lwezofuzo (oko kukukhawuleza ngokukhawuleza), unyango luyahlukahluka ngokusekelwe kwimizimba yomntu ngamnye.
Imithombo:
Gourraud, PA, Harbo, HF, Hauser, SL, & Baranzini, SE (2012). I-genetics ye-multiple sclerosis: ukuhlaziywa kwangoku. Iziphumo ze-Immunological , Julayi; 248 (1): 87-103.
I-International Multiple Sclerosis Genetics Consortium, et al. (2007). Iindlovu zengozi ze-sclerosis ezininzi ezichongiweyo zifunyenwe ngophando lwe-genome. I-New England Journal of Medicine, uAgas 30; 357 (9): 851-62.
National Society of MS. Ngubani ofumana i-MS? (Epidemiology).
National Society of MS. Iinkcukacha eziSiseko: i-Genetics.
Sadovnick, AD, et al. (1993). Isifundo esisekelwe kubemi besifo se-sclerosis ezininzi kumawele: hlaziya. Ama-Annal of Neurology, Mar; 33 (3): 281-5.