Akukho Philisi Kodwa, kodwa i-Western Diet ingabikho i-Triterpenes
I-Lupeol, eyaziwa nangokuthi i-fagarsterol, yinkampani yemvelo efumaneka kwizityalo ezithile kwimvula yamanzi, kunye nokutya ezithile. I-Lupeol inomdla kakhulu kwizenzululwazi ezenza uphando lwezinto eziphilayo ezinokuthi zineempawu zonyango. Uphando lukhawulelwe kwii-vitro nezifundo zezilwanyana, ngoko kusasa kakhulu kwisigaba sokufumanisa, kodwa iLupeol ibonakala inezakhiwo ezichasayo nezichasa umdlavuza kwezinye zezi zifundo.
Uluphi Lupeol?
I-Lupeol yile iqela lamaqumrhu abizwa nge-triterpenes. I-Triterpenes ibalulekile kwimimandla yesikhumba seesityalo. Ezi zixhobo zisebenza ngokufanayo ne-cholesterol kwiimbumba zeesilwanyana-oko kukuthi, zinceda ukugcina i-bilayers kwimimbrane yesityalo esomeleleyo. I-Triterpenes yenzelwe izifundo ezingama-25 ezahlukahlukeneyo zekliniki kwaye zenza umdla kwiindawo zabo zokunciphisa i-cholesterol .
Kwintshona, kulinganiselwa ukuba sidla malunga ne 250 mg ngosuku lwe-triterpenes, ngokuyininzi itholakala kwioli yemifuno, okusanhlamvu, iziqhamo kunye nemifuno. Ukungena kwetriterpenes kunokuba kuphakame kakhulu kumazwe aseMedithera nakubantu abanesidlo esityebileyo kwioli yeoli.
I-Lupeol yinto ehamba phambili enomdla okhethekileyo. Izifundo ezinika ulwazi malunga nomsebenzi we-biologic waseLupeol zibonisa ukuba yi-agent ejolise kuyo. Kuye kucatshangelwa ukuba ihileleke kwiindlela ezinqamlekileyo zeemolyuli ezibandakanyeka ekuvukeleni kunye nomhlaza.
Ziyini Imithombo YaseLupeol?
I-Zanthoxylum yintlobo engama-250 yeemithi kunye nezihlahla kwi-citrus family, ezihlala kwindawo ezifudumeleyo kunye neendawo eziphantsi komhlaba. Ezinye zeentlobo zine-heartwoodwood, kwaye isiqhamo seentlobo ezininzi sisetyenziselwa ukwenza i-spice, iSphuan pepper. Amalungu eenjengezinye ngamanye amaxesha asetyenziswa njengemithi ye-bonsai.
I-bark isetyenziswe kwiiyeza zendoda yezinyo, i-colic, ne-rheumatism. Imithombo efanelekileyo yeLupeol kule ndawo iquka i- Zanthoxylum riedelianum, enye yemithi ende kunazo zonke zase-Peruvian Peru. Okuthakazelisayo kukuba, iLupeol ifumaneka kwisityalo esivela kwiPhilippines, uFicus pseudopalma, esetyenziswe njengeyeza lemfuyo yamatye kunye nesifo sikashukela. Iintlobo ezahlukeneyo zezityalo ngoku ziyaziwa ngokuba yimithombo enhle yaseLupeol, kwaye iLupeol ifumaneke kwiimifuno ezifana neklabishi emhlophe, pepper, ikhukhamba, utamatisi; kunye neziqhamo ezifana nomnquma, umkhiwane, imango, i-strawberries kunye neidiya ezibomvu.
Ngaba iCoundforest Compound iya kunceda unyango kunye nokukhusela?
Ucwaningo luye lwabonisa ukuba ukutya okunotye kwiiprotochemicals (zeLupeol kuphela kuphela) kunokunciphisa kakhulu umngcipheko weengcingo ezininzi eziqhelekileyo ngokumalunga nama-20 ekhulwini.
Ingaba iLupeol iya kuba luncedo ekwenzeni unyango lomhlaza ingabonwa, kodwa ukufunyaniswa kwe- in vitro kunye nezifundo zezilwanyana eziqhutywe ngoku kuye kwandipha umdla. Mhlawumbi njengoko kukhuthazwa kukuba iLupeol, kwiindlela zayo zokwelapha ezibonakalayo, ibonakala ingabonakali inetyhefu kwiiseli eziqhelekileyo kunye nezicubu ezifundwayo. Oko kwathiwa, ukhuseleko kunye nobutyhefu abuzange luhlolwe kwizilingo zonyango zabantu, kwaye iziphumo zingachahluka kwii-vitro nezifundo zezilwanyana.
Inkqubo kwiSikolo seMicrosoft kunye neMpilo kaRhulumente, iYunivesithi yaseWisconsin-Madison ihlolisise imiphumo emihle yeLupeol ngeentlobo ezahlukeneyo zomhlaza ezifana ne-prostate, isikhumba, i-pancreatic kunye nesifo somhlaza. Ngokusekelwe kwizifundo ezibandakanyeka unyango lweeseli zomhlaza kwiintlobo ezahlukeneyo zeeseli, eli qela likholelwa ukuba iLupeol inamandla okusebenza kwiindlela ezininzi zee-molecular.
Kuthiwani Ngeengqumbo Zegazi?
Izifundo kunye neLupeol ziphambili, kwaye uphando olongezelelweyo lufunekayo ukukhanyisa lo mbuzo. Okwangoku, iziphumo ezivela kwizifundo eziliqela zangaphambili zithembisa ukuqhubela phambili umsebenzi.
Uphando oluqhutywe ngu-Aratanechemuge kunye noogxa bakhe lubonisa ukuba iLupeol yenza ukuba i-apoptosis (ukufa kweseli ehleliweyo) yee-human promyelocytic i-HL-60 cells leukemia.
Olu pho nonongo lubonisa ukuba iLupeol yenza ukuba utshintsho kwi-cell nuclei kunye nokuhlukana kwe-DNA (isimboli se-apoptosis) ngendlela exhomekeke kumthamo weLupeol onikwe.
Elinye iqela labaphandi, i-Cmoch kunye nabo basebenzisana nabo, babonisa ukuba uLupeol luchukumisa ukufa kwesisele kwiintlobo ezahlukeneyo zesifo somhlaza, kuquka i-T-lymphoblastic leukemia, kunye ne-myeloma.
> Imithombo:
> Moreau RA, Whitaker BD, Hicks KB. I-Phytosterols, i-Phytostanols, kunye neZidibanisa zabo kwiZokudla: Ulwahlulo olusesikweni, uhlalutyo olulinganisiweyo kunye nokusetyenziswa kwezeMpilo. Prog Lipid Res. 2002; 41: 457-500.
> Santiago LA, uMeya we-ABR. I-Lupeol: I-Triterpene ye-Antioxidant eFicus Pseudopalma Blanco (i-Moraceae). I-Asia Pac J I-Trop Biomed. 2014; 4 (2): 109-118.
> Saleem M. Lupeol, Inveli Yokulwa Nezikhuhlane Ne-Anti-Cancer Dietary Triterpene. Umhlaza . 2009; 285 (2): 109-115.