Intsebenziswano yeComplex phakathi kweGenetics kunye neNgqongileyo yakho
Njengengxaki yokuzimela, i-plaque psoriasis ihlala yinto engummangaliso kwindlela ebangela ngayo izifo. Nangona i-genetics idlala indima ebalulekileyo, ezinye izinto zikholelwa ukuba zinegalelo. Oko siyaziyo kukuba iimeko ezithile kunye neziphathamandla ziyakwazi ukuqala iimpawu ze-psoriasis okanye ukwandisa ubukhulu okanye ubunzima bokugqabhuka. Ziquka ukusuka kwiintsholongwane ukuya kukhuluphala, imithi yokuxininisa.
Genetics
Imbali yentsapho yona mngcipheko onamandla kakhulu wokuphuhlisa i-plaque psoriasis. Enyanisweni, malunga neyesithathu sabantu abachaphazelekayo yi-psoriasis baya kubika ukuba banelinye ilungu losapho ngesifo. Umngcipheko we-psoriasis ubonakala ukwenzeka ukuba ngaba babini ngabazali.
Nangona izazinzulu zisengabonakali ukuba i-genetics isebenza njani, baye bachonga indawo ezilisithoba kwi-gene ehambelana neempawu ze-psoriasis, eziye zabiza i-PSORS1 nge-PSORS9. Kule ndawo, malunga neepesenti ezingama-35 ukuya kuma-50 ekhulwini abantu abane-psoriasis ye-plaque baya kuba nokuguqulwa kwe-chromosomal ye-PSORS1.
Kuthemba ukuba ngokuphula i-genetic code, izazinzulu ngolunye usuku ziyakwazi "ukucima" okanye ukulungiswa kweenguqu ezinxulumene nesi sifo.
Iimpawu eziqhelekileyo
Ngelixa i-plaque psoriasis inokuchaphazela nabani na, kukho izinto ezinokubonakala zandisa ukwanda kweempawu (ezikwaziwa ngokuba yiirhari ).
Izifo
Bobabini izifo ezinobungozi ezingapheliyo zingabangela iimpawu ze-psoriasis. Siyabona oku ngokukodwa nge- HIV , isifo esingapheliyo esifana nokuvuvukala okuqhubekayo. Nangona izinga le-psoriasis lilingana nelona lilingana neluntu jikelele, ubunzima besifo sele bubi kakhulu xa i-HIV ibandakanyeka.
Ukunyanzelwa kwe-immune kubonakala kukubalulekileyo, nokuba ngaba kubangelwa yi-HIV okanye usuleleko olunjenge-bronchitis, strep throat, okanye umkhuhlane.
Ngokwahlukileyo, ukunyanga isifo kunokunciphisa impawu. Ucwaningo lubonise, umzekelo, ukuba izidakamizwa ze-statin zinokunciphisa ubunzima be-psoriasis eziqhelekileyo kubantu abaneentsholongwane ezingapheliyo. Okufanayo kubonakala kuyinyaniso xa izidakamizwa ze-antiretroviral zisetyenziswa kubantu abane-HIV.
I-Skin Trauma
Ukuxhwaleka kwesikhumba kungabangela neempawu ze-plaque psoriasis, ezibizwa ngokuba yi- Koebner . Le mpendulo ibonakala nakwezinye iimeko ezifana neengxabano, i- lichen planus kunye ne- molluscum contagiosum .
Abaninzi abantu abane abane-psoriasis bafumana oku oku, okubangelwa yiyo yonke into esuka ekushiseni kwelanga kunye nezilwanyana eziluma ukukhupha i-allergies kunye ne-needle pricks. Nokuba kunokonzakala kakhudlwana kwesikhumba, njengesilonda sokuhlinzwa okanye tattoo, kunokuba yindawo ephambili ye-psoriasis flare.
Mayeza
Amachiza athile ayaziwa ukuba aqalise iimpawu ze-psoriasis. Akunakuchaphazela bonke abantu ngendlela efanayo kwaye ayinakubangela iimpawu kuzo zonke. Nangona kunjalo, izidakamizwa eziqhelekileyo zikhankanywe ziquka:
- Lithium
- Beta-blockers
- Izidakamizwa ezichasene nezidakamizwa (nonsteroidal anti-inflammatory (NSAIDs)
- Iziyobisi ezichasene nelariya
- Abagcini bezithuthi zeCalcium
- Ukuphuhlisa imithi
Ukongezelela, ukupheliswa kokukhawuleza kwee -corticosteroids ezisetyenziselwa ukuphatha i-psoriasis kunokuba nomphumo "wokuhlawulela" kwaye kukhokelela ekugqibeleni okukhulu. Ngesi sizathu, i-corticosteroids kufuneka ihlale ikhutshwe ngokuthe ngcembe, phantsi kolawulo lugqirha, ukuba isilwanyana asisadingeki.
Izinto zokuPhila kweengozi
Ngaphandle kwemingcipheko yokuphila, kukho ezintathu ezithinteka ngokuthe ngqo kwi-plaque psoriasis: uxinzelelo, ukutshaya kunye nokunyanya.
Ukuxinezeleka
Ukuxinezeleka kunobungqina obunobangela kunye nefuthe kwi psoriasis. Ngakolunye uhlangothi, uxinzelelo lunokubangela iimpawu, ngelixa, enye, iimpawu zingabangela uxinzelelo.
Ngendlela efanayo nomzimba othumela izibonakaliso ezivuthayo ukuphulukisa isilonda, ukunyamezela kwengqondo kunokubangela impendulo yokuvuvukala enefuthe eliphambeneyo, okwenyukayo kunokuba kuphuculwe imeko.
Oku kukuxhalabisa ngakumbi kuba i-psoriasis engapheliyo inxulumene namazinga aphezulu okudakumba nokuxhalabisa. Kwezinye iimeko, umjikelezo onobungozi unokuphulwa kuphela ngonyango olufanelekileyo, olubandakanya i-psychotherapy kunye nokusetyenziswa okufanelekileyo kwezidakamizwa ezichasayo okanye ezichasayo.
Ukutshaya
Uphando olutsha luye lwabonisa ukuba abantu ababhema ngaphezu kwepakethi yecuba ngolo suku banokuphindwa kabili ukuba babe ne-psoriasis enamandla kunabo abatshiza i-cigarettes ezili-10 okanye ngaphantsi kwimihla ngemihla.
Iinzululwazi aziqinisekanga ukuba kutheni le nto kodwa ikholelwa ukuba ukutshaya kunokwandisa inani lezinto ezizimeleyo ezincinci zesikhumba (ezaziwa ngokuba yi- epidermis ). Le yile iiprotheni ezijoliswe kumachiza omzimba wokuhlaselwa ngokuzenzekelayo. Abanye baye bacetyiswa ukuba ukutshaya kubangele okanye kukhawuleze impendulo yokuzimela.
Uphando olufanayo luye lwagqiba ukuba abafazi abashushu basengozini enkulu ye-psoriasis enamandla kunamadoda. Inani leminyaka umntu atshonile nalo lunegalelo.
Ukunyanya
Ukunyamekela kunokubakho ukuveliswa kwamacwecwe ngaphakathi kwesikhumba. Nangona iinjongo ezichanekileyo ezi zinto zicacile, uphando lubonisa ukuba ukuqokelela kwamafutha amaninzi kunyusela ukuveliswa kweeprotheni ezivuzayo ezibizwa ngokuba yi- cytokines . Iicytokines ayinakwandisi kuphela ukuvutha komzimba, okwenza iimpawu zibe zibi nakakhulu, kodwa zikhuthaze ukubunjwa kwamacwecwe kwiindawo apho amaninzi amaninzi (oko kukuthi, i-fold fold).
Umbutho ubonakaliswa ngakumbi ngobudlelwane phakathi kokukhuluphala, isifo sikashukela kunye ne-psoriasis. Nangona ukukhuluphala kunokuthi i-quadruple yomngcipheko womntu wesifo sikashukela , isifo sikashukela sinokunyusa umngcipheko kunye nobunzima be-psoriasis ye-plaque ngama-27 ekhulwini.
> Imithombo:
> Arias-Santiago, S .; Espiñeira-Caromona, M .; kunye no-Aneiros-Fernández, J. "I-Koebner Phenomenon: i-Psoriasis kwiTattoos." I- CMAJ . 2013 uMbhi 16; 185 (7): 585. PMCID: PMC3626811.
> Armstrong, A .; Harskamp, C .; kunye ne-Armstrong, E. "Umbutho phakathi kwePororiasis kunye noTyhutyhulo ukuVavanywa koHlolo kunye ne-Meta-Analysis of Studies Observational Studies." I- Nutritive Diabetes. 2012 I-3: 2: e54. INGXELO: 10.1038 / nutd.2012.26.
> Armstrong, A .; Harskamp, C .; Dhillon, J. et al. "I-Psoriasis kunye noTshwala: Uhlolo lokuHlola kunye nokuHlanywa kweMeta." I- Br J Dermatol . 2014 Feb; 170 (2): 304-14. INGXELO: 10.1111 / bjd.12670.
> Jankovic, S .; Raznatovic, M .; Marinkovic, J. et al. Izinto ezinobungozi ze-Psoriasis: Isifundo soLawulo lwe-Case. " J Dermatol. 2009 Juni; 36 (6): 328-34. INGXELO: 10.1111 / j.1346-8138.2009.00648.x.
> Mosiewicz, J .; Pietrzak, A .; Chodorowska, G et al. "Ukuqikelela ukusetyenziswa kwesimo semifanekiso kwizigulane ze-psoriatic." I- Arch Dermatol Res . Ngo-Agasti wama-2013; 305 (6): 467-72. INGXELO: 10.1007 / s00403-013-1374-1.