Kungathi ngathi uhlekisayo okanye umdlalo, kodwa ukuba uke wahlaselwa yindlala emva kokuyeka iipilisi zokulala, awuyi kuluhlabala. Yintoni i-sleepiness insomnia? Funda indlela le meko eyenzeka ngayo nokuyeka ukulala kweepilisi (kuquka i-Ambien okanye i-yolpidem, i-Lunesta, i-Benadryl, i-Klonopin, i-Ativan, kunye nokunye), ixesha elide lihlala lixhomekeke kwi-half life-life, kwaye ungakuphepha njani kwaye uphathe imiphumo emibi yakho ukukwazi ukulala.
Sibanzi
Ukuphazamiseka kokugqithisileyo kuchazwa njengengxaki yokuqalisa okanye yokugcina ubuthongo obubi kakhulu kumxholo wokuyeka ngokukhawuleza ukulala kwamapilisi. Ubuthongo obunokuba bubi ngakumbi kunanini ngaphambili, okukhokelela abanye ukuba bafumane ukulahlekelwa ngokupheleleyo kokulala okuhlala iiyure okanye ubuthongo obunokuba bunzima ngaphezu kweentsuku.
Izizathu
Ukusetyenziswa kweepilisi zokulala kuphucula amakhemikhali asemvelo ekhoyo kwingqondo kunye nenkqubo yesifo. Ngokuxhomekeke kumachiza, ezi ziquka i-neurotransmitters njengeGABA, i-serotonin, okanye i-tryptophan, kunye ne-hormone melatonin. Elinye imithi, i-Belsomra, ibimbela uphawu oluvukayo olunikezwa nge-orexin (okanye i-hypocretin). Xa ipilisi yokulala ihoxiswa ngokukhawuleza, ingqondo ishiywe kwinqumle, phantse nje ukuba uyidonsa umbhoxo ngaphandle kwayo.
Iinkqubo zokulala nokuvuka zilindele ukuba khona kweekhemikhali zamachiza. Inkqubo yakho yangaphakathi ingahle ibe phantsi-ilawulwe kwinqanaba elithile ukulawula la manqanaba ekhemiksi okwandisiwe.
Ukuba unokuyeka ngokukhawuleza ukuthatha uncedo lokulala, kukho intsalela engayihlawulwa kuqala. Oku kuya kuqondwa ngokwemigaqo yokunyamezela nokuxhomekeka.
Xa umntu enyamezela unyango olufana neepilisi zokulala, zifumanisa ukuba zifuna amanye amayeza ukuba afumane impembelelo efanayo.
Isebenza ngokuncinci kwaye iphantsi kwaye ingayeka ukusebenza ngokupheleleyo. Ngokuxhomekeke kwiyeza elisebenzisiweyo, oku kunokubangela ukuxhomekeka kwenyama. Ezinye zeemithi zonyango, kubandakanywa ne- benzodiazepines njengeKlonopin kunye ne-Ativan, zingakhokelela kwisifo sokurhoxiswa xa zithathwa kwizinga eliphezulu kwaye zanqamuka ngokukhawuleza. Oku kunokukhokelela ekutshintsheni kwexinzelelo lwegazi kunye nenqanaba lentliziyo kwaye kunokususa nokutshatyalaliswa.
Kuthatha ixesha elingakanani ukuphazamiseka kokugqibela?
Ukugqithisa okungaqhelekanga kuya kwenzeka emva kokusetyenziswa kwansuku zonke kwimiyeza yokulala, ngokukodwa kwimilinganiselo ephezulu, xa ngokukhawuleza umisiwe. Kungenzeka nanoma yiyiphi i-counter-counter-counter okanye i-prescription aid aid sleeps. Ubungakanani bokuba usweleko olungaphumeleli lunokuxhomekeka kwindlela ovakalelwa ngayo ukukhutshwa kwayo. Inokudityaniswa kwezinye izinto ezibangela ukungakwazi ukulala. Kwakhona kuya kuba namava xa kunokwenzeka ukuba le nkunkuma inomdla obuncinane, kunye namazinga awela ngokukhawuleza.
IHlf-Lives of Sleeping Pills
Ngokuqhelekileyo, isiqingatha-sobomi bonyango singakunika isikhokelo malunga nobude bokusilela ukulala. Isiqingatha-esichengeni sezilwanyana sisisombululo sithuba esithatha i-1/2 yesichengiselwano ukuba sibe ne-metabolized, ilahle amanqanaba ayo emzimbeni.
Ngokomzekelo, ukuba isilwanyana sineeyure ezingama-4, ubunqanaba bayo buya ku-12.5% wamanqanaba okuqala kwiiyure eziyi-12 (50% kwiiyure ezingama-4, i-25% kwiiyure eziyi-8, kunye ne-12.5% kwiiyure eziyi-12).
Ezinye zezona zixhobo eziqhelekileyo zokulala kunye nezo-half-life-life-life, kwiibhareneses, zibandakanya:
- I-Benadryl okanye i-diphenhydramine (ii-3.4 ukuya kwi-9.2 iiyure)
- Unisom okanye i-doxylamine (iiyure ezili-10)
- I-Ambien , i-Ambien CR, okanye i-zolpidem (iiyure eziyi-2.5 ukuya kwe-3.1 iiyure)
- I-Lunesta okanye i-eszopiclone (iiyure eziyi-6)
- Sonata okanye i-zaleplon (iyure)
- Silenor okanye i-doxepin (iiyure ezili-15.3 zeziyobisi zomzali, iiyure ezingama-31 zeemetabolites)
- I-Belsomra okanye i-suvorexant (iiyure eziyi-12)
- I-Trazodone (iiyure ezingama-3-6 kwisigaba sokuqala, iiyure ezingama-5-9 kwisigaba sesibini)
- I-Rozerem okanye i-ramelteon (i-1-2.6 iiyure zokusetyenziswa kweziyobisi zomzali, iiyure ezingama-2 ukuya kwii-metabolites)
- Xanax okanye alprazolam (iiyure eziyi-11.2)
- I-Ativan okanye i-lorazepam (iiyure eziyi-14)
- I-klonopin okanye i-clonazepam (iiyure ezingama-20-50)
- I-Valium okanye i-diazepam (iiyure ezingama-30-60 zonyango lomzali, iiyure ezingama-30-100 zeemetabolites)
Isilwanyana esinomlinganiselo omncinci wobomi siya kuphuma kwenkqubo yakho ngokukhawuleza kwaye ukulala kwe-insomnia kungaphaya kakhulu kwaye kuqalwe ngokukhawuleza. Ngethamsanqa, liza kusombulula ngokukhawuleza, ngokukhawuleza linyuka phakathi kweentsuku ezimbalwa ukuya kwiveki emva kokuyeka amayeza. Ukusetyenziswa kweemithi ezinokuthatha ixesha elide akuvumelekanga ukuba kungabonakali ukulala, kodwa kungathatha ixesha elide ukuba isilwanyana sishiye ngokupheleleyo inkqubo yakho. Ezi zi yobisi zinokuthi zibangele imiphumo yomsindo wesantya.
Unyango
Ukuba uthabatha imithi yokulala, kwaye ngokukhawuleza xa uyeka ukulala kwakho kubuyele, ngezinye iinkqubo ezimbi kunakuphi na, unokuzixelela ukuba uyayidinga ngempela imithi ukuze ulale. Ezi ziphumo zihlala zifutshane, zihlala zixazulula ngeentsuku ezimbalwa ukuya kwiveki. Kungakunceda kakhulu ukunciphisa umthamo ngokuthe gqolo phantsi kolawulo lugqirha wakho. Oku kubaluleke ngakumbi ukuba uthatha amayeza aphezulu okanye usebenzisa iyeza ze-benzodiazepine.
Unokulingwa ukuba ungene endaweni yamachiza omtsha ukuba uyeke. Melana nesilingo. Iba ngumdlalo wegobolondo ongapheliyo: ukutshintshwa kwamanye amayeza ngaphandle kwento entsha. Endaweni yoko, cinga ukulungisa ixesha lakho lokuma, ufumane imizuzu eyi-15-30 yelanga ekuvukeni, uze ulale xa uziva ulele. Ngokulibazisa ixesha lakho lokulala kunye nomqobo wokulala (kuphela ukuchitha iiyure ezingama-6 ukuya kwii-7 kwixesha lokulala) ngeli xesha le-rebound, uya kulala ulala kwaye ubalekise le miphumo emibi.
I-ounce yothintelo inokuthi ifanele i-pound yeyeza. Ngokuqhelekileyo, kulungile ukuphepha ukusetyenziswa kweepilisi rhoqo. Ungazivumeli ukuba ukwandisa amaxabiso, ngokugqithiseleyo kunokuba ugqirha wakho uphakamise kuwe. Zama ukungasebenzisi amayeza amaninzi ngokukhawuleza kwaye ungayisebenzisi ngotywala njengoko oku kunokukhokelela ekugqibeleni nokufa.
ILizwi
Ukuba ufumanisa ukuba udinga iipilisi zokulala ezingaphezu kweeveki ezimbini, thetha nodokotela wakho malunga nezinye iindlela, kuquka nokusetyenziswa kwengqondo yokuziphatha yokulala (CBTI) . Olu unyango luya kuba luncedo kakhulu kukunceda ukuba uthayiphe amayeza ngelixa ubeka ezinye izakhono endaweni ukukhusela ukuguqulwa kwesibindi.
> Imithombo:
> Epocrates Rx Pro. I-Version 15.12, 2016. Epocrates, Inc. I- San Mateo, eCalifornia.
> Qaseem A, et al . "Ulawulo lwe-Chronic Insomnia Disorder kuBantu abadala: Isikhokelo seZiklinikhi ezivela kwi-College of Physicians." Ann Intern Med . 2016; 165 (2) 125-133.
> Sateia MJ, et al . " Izikhokelo zeZikliniki zoLwazi lwe-Pharmacologic Treatment of Chronic Insomnia kuBantu abadala: i-American Academy yoLondolozo lwezeMpilo kwisiKhokelo seKliniki . Umbhalo we-Clinical Sleep Medicine . 2017; 13 (2): 307-349.