Abasebenzisi be-NSAID abaNinzi baKwandisa ingozi yeempembelelo ezingasecaleni
Izidakamizwa ezingekho-steroidal ezichasayo (i-NSAID) yiyona nto ingundoqo kubantu abaninzi abane-arthritis. Sekunjalo ukuthabatha amachiza angaphezu kweyodwa kule nqanaba akunikezeli nje izinto ezintle kodwa kunokuba yingozi. Ziziphi kanye ii-NSAID, ziphi iingozi, kwaye yiyiphi imichiza efakiwe kuloluhlu ukuze uqinisekise ukuba awuyi kuphinda uhlawule ngokuphindaphinda kabini kwididi ezifanayo?
Ziziphi ii-Non-Steroidal Anti-Inflammatory Drugs (i-NSAID)?
Izidakamizwa ezichasene nezidakamizwa (i-NSAID) ezingekho phantsi kwe-nonsteroidal zididi lwezonyango eziqhelekileyo ukunyanga i- arthritis .
Ekubeni i-NSAID zifumaneka zombini kunye ne-counter-counter, abanye abantu bagqiba ukuthatha ii-NSAID ezimbini ezahlukeneyo.
Abantu banokukhetha ukuthabatha ii-NSAID ezimbini ngenxa yokuncedwa kweentlungu ezingekhoyo okanye ngenxa yokuba abaqapheli zombini izidakamizwa zisesigaba esifanayo sonyango. Ukusebenzisa ii-NSAID ezimbini ezihlukeneyo zizinzileyo kwaye akusiyo ingcinga efanelekileyo, kuba ukwenza njalo kunokunyusa umngcipheko wemiphumo engathandekiyo kunye neziganeko ezingathandekiyo.
IiNSAID ezidumileyo zineengozi
Unokucinga ukuba isisu siphumelele njengesiphumo esiqhelekileyo sokuthatha iyeza ezifana ne-Advil, kodwa kukho iziganeko ezinokuthi zifanele ukuba wazi.
Ukuphuma kwegazi: Izigidi zabantu zithatha i-NSAID imihla ngemihla ngenxa yesifo se-arthritis, ukulimala kancinci, kunye neenkampu zokuya esikhathini.
Kuqikelelwa ukuba abangaphezu kwe-100,000 baseMerika bahlala esibhedlele kwaye phakathi kwe-15 000 no-20,000 bayafa ngonyaka ngamnye ngenxa yezilonda kunye nokuphuma kwegazi ngokuphathelele ukusetyenziswa kwe-NSAID. (Ukuqonda ubungakanani beli, abafazi abangama-40 000 bafa ngomdlavuza wonyaka ngamnye ngonyaka). I-akhawunti ye-NSAID i-60 yeepesenti yeemfuno ezingaphezu kwe-counter-counter-counter, kunye nabantu abasebenzisa i-NSAID nganoma yintoni na isizathu, ipesenti enye ukuya kweyibini iya kuba nama-GI kuphuma.
Ukuthetha kuphela nge-arthritis, izigulane ezili-14 zezigulane zithatha ii-NSAID rhoqo-ukuya kuma-60 ekhulwini abo baya kuba nemiphumo yesisu esiswini ngenxa yesiphumo. Umngcipheko uphezulu kulabo asebekhulile, nabo bathabatha i-aspirin okanye abagcini begazi, abathatha iintlobo ezithile kunye namayeza e-NSAID, kwaye ukuba ngaphezulu kweyeza elilodwa kulolu hlobo lusetyenziswa.
Ukuhlaselwa yintliziyo kunye nobungozi be-stroke: Ukusetyenziswa kwe-NSAID kudibaniswa nobungozi bokuhlaselwa kwintliziyo okanye isifo esingaholela ekufeni-kwaye umngcipheko ukhuphukela kwizigulane ezisebenzisayo ixesha elide okanye nesifo senhliziyo. Kukho ii- NSAID ezithwala ingozi yomzimba kunezinye, kwaye kubalulekile ukuba uthethe ugqirha wakho malunga neempawu zakho ze-arthritis kunye nembali yakho yentsapho okanye yesifo senhliziyo kunye nemingcipheko. kwesi sizathu.
Umonakalo wezintso: Nokuba iimeko eziqhelekileyo ze-NSAID ezisetyenziselwa iimeko ezincinci zingabangela ukulimala kweentso ezinzulu ( ukungaphumeleli komnxeba .) Ihlabathi liqikelelwa ukuba abantu abayizigidi ezi-2,5 bafumana ukungaphumeleli kwe-renal ngenxa ye-NSAID ngamnye ngonyaka.
Iingcebiso zokusetyenziswa ngokukhuselekileyo kwe-NSAID
I-FDA ikhuthaza ukuba ukusetyenziswa okukhuselekileyo kwe-NSAID, amayeza kufuneka athathwe:
- Kuphela njengoko kuchaziwe
- Kwiqondo eliphantsi kakhulu elisezantsi elisebenzayo
- Ngexesha elifutshane elifunekayo
Kuye kwaxelwa ukuba abantu bahlala bexela ukusetyenziswa kwabo kwe-NSAID ezingaphezulu kwe-counter. Uphando lufumene ukuba abantu abangabonakali ngaphezu kwe-counter-counter-N-use usetyenziso lwe-NSAID bakholelwa ukuba iziyobisi azibalulekanga kuba zifumaneka ngaphandle komyalelo. Oku akunjalo nje kwaye sinesizathu esinye (kukho ezininzi) kutheni abantu bamele baqaphele ugqirha wabo nayiphi na i-counter-counter-counter or supplements they take.
Ukuhluleka ukwazisa ugqirha we-over-the-counter usetyenziso lwamachiza ngenye yezizathu ngezihlandlo abantu ngokugqibeleleyo baphela basebenzisa iziyobisi ezimbini kulolu hlobo nangona ingaba yingozi.
Ukuthatha ii-NSAID ezimbini zibungozi
Ingozi eyongeziweyo enxulumene nokuthatha ii-NSAID ezimbini zibalulekileyo. Uphando oludala olupapashwe kwi- European Journal ye-Clinical Pharmacology lugqibe ukuba umngcipheko weempatho ezinobungozi obangela ukulimala kwesibindi kunye nokungaphumeleli kwe-renal ngokuphindaphindiweyo kwimizuzu engama-6 kuya kwe-7 ephakamileyo kwiimeko ezichazwe ngokusetyenziswa kwamanye ama-NSAID. Sekunjalo nangaloo nkcazelo, umngcipheko uhlala. Ucwaningo lwango-2017 lubonise ukuba phakathi kwabantu abadala abadala abathatha ii-NSAID, ukusetyenziswa okungafanelekanga kuye kwafunyanwa ngaphezu kwama-70 ekhulwini.
Musa ukuvumela ukuba kwenzeke kuwe. Sebenzisa ii-NSAID ngokukhuselekileyo nangokufanelekileyo. Ukuba usuvele uthatha imithi ye-NSAID, jonga ugqirha wakho phambi kokuthatha nayiphina imithi.
Iziyobisi ezibizwa ngokuba yi-NSAIDS
Ukuze ugweme ukuthatha i-NSAID engaphezulu kweyodwa, kubalulekile ukwazi ukuba zeziphi iziyobisi ezifakiwe kule klasi. Kwakhona kubalulekile ukuba uqaphele ukuba imithi yonyango ingathengiswa phantsi kwamagama amanqaku ahlukeneyo. Ngokomzekelo, ibuprofen yonyango lomuthi ku-Advil, Motrin, Nurofen, nabanye. I-NSAID inokudibaniswa namanye amayeza.
Kukho iintlobo ezintathu eziphambili ze-NSAID. Ezi ziquka i-salicylates (zombini i-acetylated njenge-aspirin engama-acetylated,) i-NSAID yendabuko (njenge-Advil,) kunye ne-COX-2 inhibitors, njengeCelebrex. Ii-NSAID eziqhelekileyo ezisetyenziselwa ukunyanga i-arthritis ziquka:
- Actron (ketoprofen)
- Aleve (naproxen)
- Anaprox (naproxen)
- I-Ansaid (flurbiprofen)
- Arthrotec (i-diclofenac ne-misoprostol)
- I-Aspirin (i-acetylsalicylic acid)
- Advil (ibuprofen)
- I-Cataflam (i-diclofenac potassium)
- Celebrex (celecoxib)
- I-Clinoril (sulindac)
- Daypro (oxaprozin)
- Disalcid (salsalate)
- Dolobid (diflunisal)
- Feldene (piroxicam)
- Ibuprofen (amagama e-brand names include Motrin, Advil, Mediprin, Nuprin, Motrin IB)
- Indocin (indomethacin)
- Ketoprofen (amagama aquka amagama a-Orudis, i-Oruvail, i-Actron, i-Orudis KT)
- ILodine (etodolac)
- Meclomen (meclofenamate sodium)
- I-Mobic (meloxicam)
- Motrin (ibuprofen)
- Nalfon (fenoprofen)
- Naprelan (naproxen)
- Naprosyn (naproxen)
- I-Naproxen (amagama egama-magama aquka uNaprosyn, uAleve, iNaprelan, i-Anaprox)
- Orudis (ketoprofen)
- I-Oruvail (ketoprofen)
- I-Ponstel (i-mefanamic acid)
- Relafen (nabumetone)
- I-Tolectin (tolmetin sodium)
- Hlanganisa (choline magnesium trisalicylate)
- I-Voltaren (i-diclofenac sodium)
Ngaphantsi kwi-Takwimu ezingaphezulu kweNSAID eyodwa
Ukuthatha i-NSAID engaphezulu kweyodwa ayinanto yokuphucula ulawulo lweentlungu, kodwa luyandisa kakhulu umngcipheko weempembelelo eziqhelekileyo kunye nezimpembelelo ezimbi. Oko kwathiwa, abantu abaninzi kakhulu baphela basebenzisa ngaphezulu kweyodwa kwala mayeza ngexesha. Ingxenye yengxaki kukuba la mayeza ayatholakala ngokubhaliweyo kunye ne-over-counter-counter, kwaye ukuba ugqirha wakho engazi ukuba unyango olungagunyazisiweyo uthatha, impazamo ingabonakali.
Ukongeza kokuphindwe kabini kwi-NSAID, kukho imiphumo emininzi enokubakho kunye nokusebenzisana phakathi kwamachiza abantu abasebenzisa i-arthritis. Indlela efanelekileyo yokunciphisa amathuba okuba nomphumo ongathinteli kukuxoxa ngokucophelela ngamachiza ngamnye owathathayo kunye noogqirha wakho kunye nekhemistiki yakho. Xa kukho iimpazamo zezobugqirha ezithathwa njengeyona yesithathu ebangela ukufa eUnited States, ihlawuleka ukuba ilumkele.
> Imithombo:
> Kasper, uDennis L .., u-Anthony S. Fauci, noStephen L .. Hauser. Iinqununu zeHarrison zeMithi yoPhakathi. ENew York: imfundo kaMc Graw Hill, 2015. Print.
> Luciano, R., noM. Perazella. I-NSAID: Ukulimala kweentso ezintle (ukungaphumeleli ngokusemthethweni kwe-Renal). UpToDate . Ukuhlaziywa 03/01/17.
> Sostres, C., Gargallo, C., kunye noL. Ingelosi. Izidakamizwa ezichasayo ezingekho phantsi kwe-Antisteroidal kunye neMonakalo ye-Mucosal Ephezulu kunye neNcinci. Uphando lweArthritis kunye noTyhulwa . 2013. 12 (iSiza 3): S3.