Iharharnate , eyayiqwalaselwa njengento engathandekiyo, ngoku iyakuthandwa kakhulu. Ijeromnate ijusi ifunyenwe phantse yonke ivenkile eNorth America.
Kodwa ingxelo yecala epapashwe ngo-Septemba 1, 2006, umxholo we- American Journal of Cardiology ukhombisa ukuba igromegranate inokusebenzisana namayeza aqhelekileyo.
Indoda eneminyaka engama-48 yayithatha i-ezetimibe (Zetia®) i-10 mg ngosuku kunye ne-rosuvastatin (iCrestor®) 5 mg nganye imihla ngemihla eyi-17.
Zomibini iziyeza zisetyenziselwa i-cholesterol ephezulu.
Waqala ukusela igromgrate juice (200 ml kabini ngeveki) kunye neveki ezintathu kamva, wavunyelwa ngxamnye noxinzelelo lwethanga kunye nenqanaba eliphezulu le-serum creatine kinase (138,030 U / L, eqhelekileyo <200 U / L). Zomibini zibonakaliso ze-rhabdomyolysis, imeko ebalulekileyo eyenza ukuphazamiseka kwemizimba ye-muscle kwaye ingakhokelela ekuphelelweni kwezintso.
I-Rosuvastatin yileli qela lamayeza abizwa ngokuba yi-HMG-CoA ekunciphiseni i-inhibitors, okanye 'izitembu'. Ijusi yamagilebhisi iyaziwa ukwandisa umngcipheko we-myopathy eyenziwa ngumntu, kodwa ngoku kubekho ulwazi oluncinane malunga nokuba igromegranate ijusi inokunyusa ingozi.
Ijomegranate ijusi kunye nejusi yamagilebhisi, bobabili baziwa ukuvimba i-cytochrome P450 3A4 iinkqubo ze-enzyme kumathumbu. Ngokukuvimbela le enzymes, iigusi zinganyusa amanqanaba egazi amaninzi.
Ukubambisana kweMarharnate-Drug
- I-Antiarrhythmics - i-Amiodarone (iCordarone®), i-disopyramide (i-Norpace®), i-quinidine
- I- calloum- blockers - i-Felodipine (i-Plendil®), i-nicardipine (i-Cardene®), i-nifedipine (i-Procardia®), i-nimodipine (i-Nimotop®), i-nisoldipine (i-Sular®)
- I- Statins-Atorvastatin (Lipitor®), i-lovastatin (Mevacor®), i-simvastatin (iZocor®)
- I-Immunosuppressants - I-Cyclosporine (i-Sandimmune®, i-Neoral®), i-tacrolimus (i-Prograf®)
- I-protease inhibitors - i-Saquinavir (i-Fortovase®)
Nangona kunjalo, i-juice yamarharnate inokuphinda ihlangane kunye namachiza angenalo luhlu.
Iziyobisi ze-ezetimibe ne-rosuvastatin azicingelwa ukuba ziphulwe phantsi yi-cytochrome P450 3A4.
Ngokusekelwe kubungqina obuncinci malunga nokusebenzisana kwezidakamizwa, kubalulekile ukuba uthethe nodokotela wakho ukuba uthatha amayeza kwaye ucinga ukusela igromegranate ijusi.
Imithombo:
Hidaka M, Okumura M, Fujita K, Ogikubo T, Yamasaki K, Iwakiri T, Setoguchi N, Arimori K. Imiphumo yegromegranate ijusi kwi-cytochrome yabantu p450 3A (CYP3A) kunye ne-carbamazepine pharmacokinetics kwiiriti. Ukusetyenziswa kweMetabolism kunye nokuCandwa. 33.5 (2005): 644-8.
Kim H, Yoon YJ, Shon JH, Cha IJ, Shin JG, Liu KH. Imiphumo yokuvimbela izityalo zejuno kwiYPPAA. Ukusetyenziswa kweMetabolism kunye nokuCandwa. 34.4 (2006): 521-3.
I-Sorokin AV, iDuncan B, iPanetta R, Thompson PD. I-Rhabdomyolysis ehambelana neerharnate ijusi yokusetyenziswa. I-American Journal yeCardiology. 98.5 (2006): 705-6.
Ukuziphendulela: Ulwazi oluqulethwe kule ndawo lujoliswe kwiinjongo zemfundo kuphela kwaye alithathi indawo yeengcebiso, ukuxilongwa okanye unyango ngumgqirha onelayisenisi. Akunakuthetha ukukhusela zonke iindlela zokulondoloza, ukusebenzisana kwezidakamizwa, iimeko kunye nemiphumo emibi. Kufuneka uncede unyango lwangonyango ngokukhawuleza kuyo nayiphi na imiba yempilo uze ubonane nodokotela wakho ngaphambi kokusebenzisa elinye iyeza okanye wenze utshintsho kwi-regimen yakho.