Indlela Esebenza Ngayo Kwiimpawu Eziqhelekileyo ze-PCOS Njengeenwele ezingabonakaliyo
I-Polycystic i-ovary syndrome (i- PCOS ), isifo esisodwa se-endocrine phakathi kwabasetyhini abanokuzala, ibonakala nge-hyperandrogenism (amanqanaba aphezulu amahomoni angamadoda, afana ne-testosterone) kunye ne-octatory dysfunction.
Ezinye zezona ziimpawu ezibuhlungu kakhulu abafazi abanamava e-PCOS ziquka iinwele: ukulahleka kweenwele kunye neenwele zomzimba kakhulu (i-hirututism). Iziphumo zophando olushicilelwe kwi-PLOS One, iphephancwadi eliphononongwa ngontanga, lufumene ukuba i-hirsutism inefuthe eliqinileyo kwimilinganiselo enxulumene nempilo yemilinganiselo yobomi kubasetyhini base-Iranian abafumene i-PCOS.
Imiphumo ye-hirsutism ayithatha kuphela ixesha elide lokulawula, lichaphazela umgangatho wobomi kunye nokuzithemba.
Abasetyhini abane-PCOS abanobungozi be- hirsutism banokumiselwa i-Flutamide, iyeza elisebenza njenge-anti-androgen.
Indlela iPrutamide isebenza ngayo
I-Flutamide (igama eliqhelekileyo elithi Eulexin), lisebenza ngokuthintela i-androgens, eyiqela lamahomoni adlala indima kwiimpawu zesintu kunye nomsebenzi wokuzala.
I-70-80% yabasetyhini abanee-orrogens ezingaphezu kwemali babonisa i-hirsutism. I-Androgens ikwandisa izinga lokukhula kweenwele kwaye liguqule elifutshane, elihle, elikhanyayo, iincinci zentombazane (i-vellus izinwele) ukuya kwiinwele ezinqamle, ezide, kunye ezimnyama. Xa i-androgens iyancishiswa, ukunyuka kweenwele ezintsha kuncitshiswa kwaye ukukhula kweenwele eziphelileyo zikhoyo.
I-Flutamide ikhusela i-androgen receptors kwiinwele zeentloko zeenwele kwaye i-androgens ayikwazi ukudibanisa nama-receptors. Xa i-orrogens kwiintloko zezinwele zivaliwe, ukulahlekelwa kweenwele ezinxulumene ne-PCOS kunye ne-hirsutism kuncipha.
Oku kunokunciphisa iimpawu ze-PCOS , ngokukodwa ukukhula kweenwele ezidlulileyo kunye ne-PCOS, nangona i-Flutamide ayizange ivunyiwe yi-FDA kule ndlela yokusetyenziswa.
Abasetyhini abaninzi abathwala i-Flutamide bayazibona iinwele ezinqabileyo kunye neenwele ezingaphantsi komzimba. Inxalenye efanelekileyo ye-Flutamide kukuba ayikho i-steroidal kwaye ayichaphazeli umsebenzi wezintso njengezinye i-anti-androgens.
I-Flutamide ayisebenzi ngokukhawuleza. Izinwele zikhula ngamaxesha ahlukeneyo kwaye isigaba sokukhula siyahluka ngokwemimandla yomzimba, ngokukhula okupheleleyo, lo mjikelo wokukhula ubuncinane malunga neenyanga ezine zobunwele bomzimba. Yingakho kunconywa ukuba unikeze unyango oluchasene ne-androgen ngaphezu kweenyanga ezili-6 ukuba lusebenze ngokupheleleyo.
Isistim kunye neempembelelo ezingasemva
Umlinganiselo oqhelekileyo we-Flutamide kwi-PCOS ngowama-125 mg okanye iifomsules ezingama-250 zimbini ukuya kwezihlandlo ezintathu ngosuku. Nceda ubhekiselele kwikhowudi yakho yegulane malunga nexabiso elichanekileyo lemilinganiselo yeemeko zakho. Njalo ulandele icebiso logqirha wakho ngaphambi kokuba uqalise nayiphi na imirhumo.
Ezinye zeempembelelo eziqhelekileyo zePlutamide ziquka:
- kulala
- ukuxinezeleka
- kudideka
- isifo sohudo
- isicaphulelo
- ukuhlanza
- kushushu
- ukulahleka kwe-libido
- ukukhawuleza
- ukuvuvukala
- isikhumba esomileyo
- iziphoso zokuzalwa
Oku akusiyo uluhlu olupheleleyo lweempembelelo kwaye abanye bangenzeka. Xhumana nodokotela wakho ukuba ufumana naziphi na iziphumo ezilandelayo.
Ezinye Imiyalelo
Ukuhlolwa kwegazi rhoqo kunconywa ukuba kuhlolwe umsebenzi wesibindi kunye negazi kunye nokuthintela inetyhefu ekutheni i-Flutamide.
Kubaluleke kakhulu ukuba ungakhulelwa ngelixa uthabatha i-Flutamide, ngenxa yobungozi obunokuba ngumntwana okhulayo. Qinisekisa ukusebenzisa ifom esebenzayo yokulawula ukuzalwa kwaye ungalusisi xa usebenzisa le nkunkuma.
Bika nayiphina imiphumo engavumelekanga kwidokotela wakho ngokukhawuleza.
Imithombo:
Ibanez L, Potau N, Marcos MV, de Zegher F. Ukwelashwa kweHirsutism, Hyperandrogenism, Gligomenorrhea, Dyslipidemia, kunye ne-Hyperinsulinism kwi-Nonobese, Amantombazana ase-Adolescent: Impembelelo ye-Flutamide. J Clin Endocrinol Metab. 2000 Septemba; 85 (9): 3251-5.
> Mahnaz Bahri Khomami, Fahimeh Ramezani Tehrani, Somayeh Hashemi, Maryam Farahmand, kunye neFereidoun Azizi. Iimpawu ze-PCOS, i-Hirsutism ineyona nto ibalulekileyo kwiMpilo yobomi base-Iranian Women. PLoS One. 2015; 10 (4): e0123608.
Muderris II, Bayram F, Guven M. Ukwelashwa kweHirsutism Nge-Lowest-Dose Flutamide (62.5 mg / ngosuku). Gynecol Endocrinol. 2000 Feb; 14 (1): 38-41.
I-Muderris II, i-Bayram F, i-Guven M. Injongo, i-Randomized Trial Ukulinganisa i-Flutamide (250 mg / d) ne-Finasteride (5 mg / d) kwiNyango yeHirsutism. Fertil Steril. Ngo-2000 ngoMeyi; 73 (5): 984-7.