Izizathu ze-Intrathecal Chemotherapy kunye neempembelelo ezingasetyenziswayo
I-intrathecal chemotherapy yintlobo ye- chemotherapy elawulwayo kumanzi phakathi kweembumba ezinomgca wengqondo kunye nomgudu womgudu. Umkhuhlane ojikeleza le ndawo uveliswa kumagqabi akho engqondo kwaye ubizwa ngokuba yi-cerebrospinal fluid okanye i-CSF. I-Cerebrospinal fluid isebenza njengesihluthulelo, ukhusela ingqondo yakho kunye nentambo yomgudu ngexesha lokunyakaza.
Sibanzi
Kukho iintlobo ze- leukemia kunye ne-lymphoma esasazeka kwi-CSF kunye neenkqubo ze-nervous. Ngelishwa, uninzi lwamachiza e-chemotherapy alukwazi ukufikelela kule ndawo ukusuka kwigazi. Phakathi kobuchopho kunye nalo lonke umzimba liluhlu lweembrane ezibizwa ngokuba ngumqobo wegazi . Lo mqobo ukhona ukugcina i-toxins engaphazamisa ingqondo. Ngelishwa, liphinde ligcine amaninzi amachiza e-chemotherapy.
I-intrathecal chemotherapy ingasetyenziswa:
- Ukunyanga umdlavuza oye wasasazeka kwi-CSF
- Ukuthintela umdlavuza ukusasazeka kwi-CSF
Iimpawu zeCarcer ziya kwaziswa kwi-CSF
Iimpawu ukuba umhlaza wakho usasazeke kwi-CSF yakho ingaquka:
- Intloko
- Ingxaki yokuthetha
- Ukuxhamla
- Iinguqu kwimibono yakho, njengombono ombini
- Utshintsho olucinga
Yintoni ongayilindela
I-intrathecal chemotherapy inokunikezwa ngefuthe lomgcini (ukugqithiswa kwe-lumbar) okanye ngokusebenzisa i-reservoir efakwe kwisiqholo sakho.
Ukugqithiswa kwe-Lumbar - Ukuba unalo uhlobo lwe-leukemia okanye i-lymphoma enomkhuba wokusasazeka kwinkqubo ye-nervous, mhlawumbi ufumene i- lumbar puncture , okanye umpompo njengengxenye yesifo sakho.
Oku kuyafana kakhulu noko uza kuvela xa ufumana i-intrathecal chemotherapy. I-oncologist yakho okanye i-hematologist iya kwenza i-lumbar puncture, kwaye ifake i-chemotherapy ngqo kwi-CSF yakho ukubulala nayiphi na iseli zomhlaza.
Umlambo we-Ommaya - Ukuba ufuna uninzi lweentlobo zonyango, ugqirha wakho unokugqiba isigqibo sokubeka "i-Ommaya reservoir" kwi-scalp yakho.
Eli gumbi linesitrato esincinci esifikela kumbane ojikeleze ingqondo yakho. Amachiza e-Chemotherapy anganikwa nge-Ommaya, kwaye awuyi kuphinda ufune iiplctures. Imithombo yamanzi i-Ommaya ishiywe kwindawo yonke kunyango lwakho kwaye ikhuselekile ukuya ekhaya.
Emva koNyango
Xa ugqirha lakho lugqityiwe, ugqirha wakho uya kulala ixesha elide ukuze uvumele i-chemotherapy ukuba ifikelele kuyo yonke indawo apho i-CSF ijikeleza khona. Ukuba unesigxina sokubambisa, uya kugcinwa kwisitrato emva kwakho kwithuba elithile ukwenzela ukunciphisa ithuba lokuphuhlisa intloko yomlenze emva komsebenzi.
Xa Ufanele Ubize Ugqirha?
Ukuba ufumene olu unyango njengomntu osisiphene, kufuneka uqhagamshelane nomboneleli wakho wezempilo xa uhlakulela:
- Umkhuhlane onesidingo esingaphezu kwe-100F okanye 38C
- Utywala okanye intloko engenakuhamba
- Ubunzima bakho emthonjeni
- Ubungqina, ukubetha, okanye utshintsho kwintsimbi okanye emilenzeni
- Unzima ukuhamba
Ngaphantsi
Iintlobo ze-leukemia kunye ne-lymphoma ezazisasaza inkqubo ye-nears ingaba nzima ukuyiphatha. Iiseli zeCans can live and multiply, mhlawumbi zingabonakali kwi-CSF apho i-chemotherapy yendabuko ayikwazi ukufikelela kubo. Ukuze uphathwe kwaye uthintele ukuba kwenzeke, oogqirha baya kulawula i-intrathecal chemotherapy ukubulala nayiphi na iseli zomzimba.
> Imithombo:
> Cheah, C., Herbert, K., O'Rourke, K. et al. I-Multicentre I-Retrospective Ukuqhathaniswa kweeNkqubo eziMbindi zeNkqubo zeProlaxis Strategies Phakathi kwezigulane ezine-High-risk Diffuse Large B-cell Lymphoma. IBritish Journal of Cancer . 2014. 111 (6): 1072-9.
> Ferreri, A., Bruno-Ventre, M., Donadoni, G. et al. I-CNS Prophylaxis ejongene nobungozi kwi-Mono-Institution Series ye-200 Iziguli ezine-Lifphoma ezinkulu zeB-cell ezenziwa kwi-Rituximab Era. IBritish Journal yeHematology . 2015. 168 (5): 654-62.
> Goodman, M. Chemotherapy: Iimigaqo zoLawulo. E-Yarbro, C., Frogge, M., Goodman, M., Groenwald, S. eds (2000) Ubunakekeli beCans : Imigaqo kunye no-5 Ed Jones kunye noBartlett: eSudbury, MA.
> Norden A., Hocherg, E., no-E. Hocherb. Unyango, ukuxhamla, kunye neProphylaxis Ukuba i-Central Central yeNervous System iLymphoma. Isemgangathweno. Ukuhlaziywa 02/03/16.
> Sekiguchi, Y., Shimada, A., Imai, H. et al. Intravascular Large B-Cell Lymphoma Nge-Pontine Ukubandakanya Ngempumelelo Ngendlela Yokuphathwa Kwama-R-CHOP kunye noLawulo lwe-intrathecal: ingxelo yeNgxelo kunye nokuHlola kweeNcwadi. I-International Journal ye-Clinical and Experimental Pathology . 2014. 7 (6): 3363-9.