Ukuba amazinga akho e-triglyceride aphakanyisiwe, ukunyamekela kwezempilo kunokwenza isigqibo sokuzama nokunciphisa amanqanaba akho ngokuguqula indlela ophila ngayo. Oku kubandakanya ukwenza ukutya kwakho okunempilo, ukulahlekelwa ubunzima, okanye ukujongana nezimo zonyango - ezifana nesifo sikashukela esingalawulwayo-esinokubangela ukuba amazinga akho e-triglyceride aphakame kakhulu. Ukuba ezi tshintsho azisebenzi - okanye ukuba i-triglycerides yakho iphakanyisiwe kakhulu - umboneleli wakho wezempilo unokugqiba ekubeni angeze imithi.
Le yilapho amayeza enjengeVascepa enokumiselwa kuwe.
I-Vascepa (icosapent ethyl) ifomu eguqulelwe i-omega-3 fatty acid, i- eicosapentaenoic acid (EPA), kwaye ithathwa ngabantu abaye bafumanisa ukuba bane- hypertriglyceridemia eqinile , equkethe amazinga e- triglyceride angaphezu kwama-500 mg / dL . Ukuba umiselwe ukuba le nyanga ithathe, kufuneka ulandele ukutya ukuze unciphise amanqanaba akho e-triglyceride. I-Vascepa ivunyelwe ukuba isebenzise eUnited States yi-Food and Drug Administration (FDA) ngoJulayi 2012.
Kukho izifundo ezimbalwa eziye zahlola ukhuseleko kunye nokusebenza kweVascepa ekunciphiseni i-triglycerides. Uvavanyo oluphambili, uvavanyo lwe-MARINE, lithelekisa ubuchule bokunciphisa i-Vascepa kwi-placebo kubantu abanamazinga e-triglyceride phakathi kwama-500 no-2000 mg / dL kwixesha leveki ezili-12. Xa kuthelekiswa ne-placebo, amazinga e-triglyceride ancitshiswe ngamaphesenti angama-33% kulabo bathabatha iigremu ezine ze-Vascepa imihla ngemihla.
Ukongezelela, i- VLDL yanciphisa i-28.6%. I-LDL kunye ne- HDL zancipha kancane, nangona kunjalo, ukunciphisa kwakungabonakali. Akukho mahluko ephawulekayo kwimpawu ebalulekileyo, amanqanaba eshukela egazi, kunye ne-enzyme yesibindi zaphawulwa ngabantu abathatha iVascepa ngokumalunga nalabo bathatha indawo ye-placebo.
I-Vascepa isebenza njani?
I-Vascepa isebenza ngokunciphisa inani le-triglycerides eyenziwa esibindi.
Ukongezelela, iVascepa ikwandisa ukususwa kwe-triglycerides kwiintlobo ze-VLDL ezijikelezayo kwigazi lakho. Indlela echanekileyo eyenziwa nguVascepa oku akungaziwa, nangona kukho iindlela ezininzi ezicetywayo.
Ungayifumana Njani Le Milisi?
Kufuneka uthathe uVascepa njengoko kuchazwe ngumboneleli wakho wezempilo. Inqanaba eliqhelekileyo leVascepa liqukethe ukuthatha iifomsi ezimbini kabini ngosuku (i-4 gram). Iifomsules kufuneka zithathwe ngokutya kwaye akufanele zichithwe, zihlafunwe okanye zinqunywe kwisiqingatha. Kufuneka ulandele indlela yokuphila enempilo - njengokufumana uvavanyo olulinganiselayo nokulandela ukutya okunesondlo - ngaphambi nangona uthabatha uVaspapa.
Ziziphi iimpembelelo ezifanele ndizithembele xa ndithatha i-Vascepa?
Kwiingcaphephe, iimpembelelo eziqhelekileyo ezichazwe zihudo kunye nesicongconi, nangona abantu abaninzi bathatha indawo ye-placebo bafumana ezi ziphumo zecala. Kananjalo nawe unokufumana intlungu kunye kunye nomqala, ngenxa yokuba ezi ziphumo ziye zaphawulwa kubantu abathatha iVaspapa.
Umele uvumele umnonophelo wakho wezempilo ukuba aziphi iintlobo zemiphumo emibi echaphazelekayo ngelixa uthabatha iVaspapa - ingakumbi ukuba ixhala okanye iphazamise imisebenzi yakho yansuku zonke.
Ngubani Akufanele Ayithathe Le Milisi?
Akufanele uthathe uVascepa ukuba unake ubenomdla omkhulu kwi-Vascepa okanye nayiphi na izithako zayo.
Ngenxa yokuba i-EPA echitshiweyo ifunyenwe kwioli ephuma kwiintlanzi, i-Vascepa kufuneka isetyenziswe ngokuqhekeza ukuba unobungozi beentlanzi okanye i-shellfish. I-Vascepa ayizange ifundwe kubantu abanentlanzi okanye i-shellfish yokungasebenzi.
I-Vascepa ayinakufundiswa ngokubanzi kubantu abaneentso okanye isifo sesibindi. Ukuba unesibindi okanye isifo se-renal okanye ukuphazamiseka, kufuneka uvumele umboneleli wakho wezempilo ukuba azi. Uya kukwenza isigqibo sokuba ngaba u-Vascepa okanye u-Vascepa ufanelekile kwaye uyayigcina imeko yakho ngelixa unyango.
Le mveliso ayizange ifundwe kubasetyhini abakhulelweyo okanye abancancisayo.
Ngoko ke, iVascepa kufuneka ithathwe kuphela xa ifunekayo ngokucacileyo.
Ngaba le Mithi iya kuhambelana nezinye iziyobisi endiyithathayo?
Akukho kubonakala ngathi kukho intsebenziswano phakathi kweVascepa kunye neminye imithi. Nangona i-Vascepa ingazange ibonakale iqhagamshelana nemithi ye-anticoagulant okanye ibe negalelo elikhulu ekuphumeni kwegazi, ezinye iingcaphephe zibonise ukuba ukunyuka kwamaqondo e-omega-3 amafutha acids kunganciphisa amandla akho egazi. Ngoko ke, ukuba uthatha nawuphi na uhlobo lweyeza elithintela amandla akho egazi lokuvala, umboneleli wakho wezempilo uya kuhlola imeko yakho ye-antiticoagulation ngezikhathi ezithile. Kufuneka uvumele umnonophelo wakho wezempilo ukuba azibandakanye nawaphi na amanye amayeza, isongezelelo semfuyo, okanye iimveliso ezingaphezulu kwe-counter before the start of Vascepa.
Okukwintsusa
Izifundo zibonise ukuba iVascepa inokunciphisa amanqanaba e-triglyceride kubantu abaye bafumanisa ukuba banamazinga aphezulu kakhulu e-triglyceride okanye ngaphezu kwe-500 mg / dL. Ukongezelela ukuthatha iVaspapa, ezinye izinto ezinokunyusa amazinga e-triglyceride - njengokutya, ukwenza izinto eziphathekayo, ezinye iziyobisi, okanye izifo ezithile, ezifana ne-hypothyroidism okanye isifo sikashukela - kufuneka ziqwalaselwe. Amanqanaba e-triglyceride aphakamileyo aphakanyisiweyo abonise ukukhokelela ekuphuhlisweni kwesifo senhliziyo kunye nokuvuvukala kwamaphancreas, okanye i-pancreatitis. I-Vascepa ayizange ifundwe ekukhuseleni izifo zesifo senhliziyo ixesha elide okanye i-pancreatitis, nangona kubonakala ngathi uphando luyaqhubeka luhlola uVascepa amandla okukhusela isiganeko sokuqala senhliziyo kubantu abantu abane-triglycerides ephezulu.
Imithombo:
> Ballantyne CM, Bays HE, Kastelein JJ et al. Ukusebenza kunye nokhuseleko lwe-eicosapentaenoic acid ethyl ester (AMR101) unyango kwizigulane eziphathwe izigulane ezinezintlu eziphezulu eziqhubekayo (kwi-ANCHOR study). InguJ Cardiol 2012; 110: 982-992.
Bays HE, Braeckman RA, Ballantyne CM, et al. I-ethyl ye-Icosapent, i-EPA ecocekileyo i-omega-3 fatty acid: impembelelo kwi-particopinin i-particle concentration kunye nobukhulu kwizigulane ezinezinga eliphezulu kakhulu le-triglyceride (i-MARINE study). J Clinic Lipidol 2012; 6: 565-572.
UNelson SD, uMayer MA. I-ethyl ye-Icosapent yokunyanga kwamazinga aphezulu e-triglyceride. UAn Ann waseMzimbeni wama-2013; 27: 1517-1523.
> Vascepa® (icosapent ethyl) Iphakheji Faka. Amarin Pharmaceuticals. Juni 2015.