I-Stelara yi-Antibody Monoclonal Eyasetyenziselwa ukulungelelanisa kwi-Crohn's
Sibanzi
I-Stelara (ustekinumab) yonyango lwe-biologic ejolise kwi-interleukin (IL) -12 kunye nee-cytokines ze-IL-23. Eyona ingcali ye-anti-monoclonal immunoglobulin antibody ejolise kwi-sub -it ye-IL-12 ne-IL-23 eyabelwe. U-Stelara wavunywa okokuqala ngo-2008 ukuphatha i-psoriasis yepenasis kwaye ngoku ivunyiwe ukuphatha unyameko kwisifo esibi se-Crohn.
Izinto ezibalulekileyo zokuzi
- I-Stelara ayiyonyango yesifo sikaCrohn
- I-Stelara inikezwa kuqala ngo-infusion kwaye emva kweeyunithi ezinokuthi zenziwe ekhaya
- Abantu abane-ntsholongwane yangoku akufanele bamkele iStralara
- Kukho umngcipheko okwandisiweyo wokusuleleka kwaye kukho naziphi na iimpawu zentsholongwane kufuneka zixoxwe nodokotela ngokukhawuleza
- U-Stelara akazange afundwe ngokubanzi ngexesha lokukhulelwa kunye nokuncelisa kwaye ugqirha kufuneka adibane nangoko kwimeko yokukhulelwa
- Izigulane kufuneka zihlolwe isifo sofuba (TB) ngaphambi kokuqala uStela
Lawulo
I-Stelara inikezelwa kwinkqubo yesibini. Unyango wokuqala kunye noStelara lwenziwe ngokunyuswa. Isilwayo sinikezwa nge-intravenously kwiziko lokungena ngaphakathi okanye kwiofisi yegqirha. Isamba seStrara esisetyenzisiweyo senziwa ngabanye kwaye sibalwa ngokusekelwe kwisisindo somguli. Emva koko, uStelara unikezwa ngamagciwane angaphantsi (i-injection ephawulwe phantsi kwesikhumba) nganye iveki ezi-8, ezinokuthi zenziwe ekhaya.
Izigulane ziqeqeshwe ngumongikazi okanye enye ingcali yezokwelapha malunga nendlela yokunika iilenki. Iyeza liza kwijectject ekhethekileyo isiguli esinikela sona okanye unomhlobo okanye ilungu lentsapho linike lona. Izigulane ziyakwazi ukufaka iSlara kwithanga, isisu, izibonda okanye ingalo engaphezulu.
Iinkcazo
I-Stelara inokumiselwa ukuba ilawule isifo esiqhathaniswayo nesifo esibi se-Crohn kubantu abangaphezu kweminyaka engama-18. I-Janssen Biotech, Inc, umenzi we-Stelara, ithi le myeza ivunyiwe kwizigulane ezinezifo zika-Crohn "ezingahambisani nokunyanga ngamayeza angama-immunomodulators okanye i-corticosteroids kodwa akazange aphumelele unyango nge- tumor necrosis factor (TNF) blocker, okanye owehlulekile okanye engavumiyo unyango kunye nenye okanye abaninzi be-block block. " Oku kuthetha ukuba kusetshenziswe kwizigulane ezaphathwa ngenye uhlobo lweyeza kwaye azizange ziphucule. Oku kungabandakanya izidakamizwa ze-immunomodulator (ezithintela i-immune system), i-steroids njenge- prednisone , okanye i-blocker ye-TNF (ngamanye amaxesha kuthiwa yi-biologics).
Ezinye izifo ezixhatshazwayo ezikhuselekileyo ezenziwa nguStelara e-United States ziquka i-psoriasis kunye ne-psoriatic arthritis. U-Stelara akavunyelwanga ngu-FDA ukunyanga i-ulcerative colitis. I-Stelara ayivunyelwanga ukuba isebenzise kubantwana okanye abaselula abangaphantsi kweminyaka eyi-18.
Ingaba isebenza kanjani
I-Stelara isetyenziselwe ukunyanga iimeko zokuxhatshazwa ngumzimba, kunye nesifo sikaCrohn sokuba sisifo esandula ukufunyanwa kuso. I-Stelara ivimbela i-interleuken (IL) -12 kunye ne-IL-23, efumaneka emzimbeni ngokwemvelo kodwa kucatshangelwa ukuba igalelo ekuvukeni kwesifo sikaCrohn.
I-Stelara ayiyonyango yesifo sikaCrohn.
Ngubani ongayifumani
Tshela ugqirha wakho ukuba unayo okanye unayo na le miqathango ilandelayo:
- Impendulo yangaphambili yokumelana no-Stelara
- I-latex ye-allergies, kuba i-syringe yangaphambili igcwele iqulethe i-latex
- Unokugonywa kutshanje kwisigontsho sokuphila, okanye ilungu lendlu yakho linegciwane lokuphila
- Ufumene isitofu sokugonywa kwe-bacille Calmette-Guerin (BCG) ngenxa yokuba akufanele kunikezwe kunyaka wokuthatha u-Stelara (mhlawumbi ngaphambi okanye emva)
- Naluphina isikhumba esikhulayo
- Ngaba okwangoku ufumana izibhengezo zokudabuka, ikakhulukazi ukuphendula ngokuthe tye
- Ngaba wakha waphathwa nge- phototherapy (ulwaphulo lwe-light)
- Ukukhulelwa okanye ukuncelisa, okanye unokukhulelwa okanye uceba ukumncelisa ngenkathi ethatha uStelara
- Yiba nembali yezifo okanye izifo zentsholongwane
Isilumkiso Sobungakanani
Isizathu esenza ukuba ugqirha kufuneka adume malunga nokukhwabanisa kwamanzi kunye nokunyamezela okukhulu kuba uStelara unokutshintsha indlela umzimba uphatha ngayo loo mifanekiso. I-Stelara inokwenza i-allergies ibonwe kakuhle okanye ikhulise umngcipheko wokuba unobungozi emva kokufumana ukudubula. Kubalulekile ukuba sisebenze ngokusondeleyo ne-allergenist kunye ne- gastroenterologist ukunciphisa umngcipheko wokuphendula. Impendulo enzima kakhulu kuStelara ayinqabile.
Izifo eziHlangeneyo
I-Stelara inokunyusa umngcipheko wokwanda kosuleleko ngenxa yokuba inokuchaphazela i- syndem sytem . Izigulane kufuneka ziqaphele ngokubeka iliso naziphi na iimpawu okanye iimpawu zentsholongwane kwaye zibaxelele ugqirha ngokukhawuleza. Oku kubandakanya:
- Intlungu zesisu
- Isiqhamo
- Ukuhlamba igazi
- Uhudo
- Ukukhathala
- Iifutha
- Ubuhlungu besisu
- Ubuhlungu okanye ukutshisa xa uvula
- Ukuqhawukelwa ngumphefumlo
- Utywala
- I sweats
- Ukulahleka kwesisindo esingachazwanga
Khu seleko
Ngexesha lokukhulelwa
Ukukhulelwa xa umama esamkela uStela akazange afundwe ngokubanzi. Kukho ukukhulelwa okukhawulezileyo kwabasetyhini abane-psoriasis ababethatha uStelara. Ezi zinto ziye zenziwa iingxelo zeemeko, oko kuthetha ukuba sisiganeko esisodwa esafundiswayo. Akuzange kubekho uphando olubanzi olujonge indlela uStelara anokuchaphazela ngayo iintsana ezingakazalwa. Ubuncinane kukhokelela ekuphumuleni komzimba, kodwa akukho phando olwanelisayo lokukwazi ukuba ngaba uStelara akanokulimaza umntwana.
Udidi lwe-FDA lokukhulelwa ngo-Stelara luhlobo B. Oku kuthetha ukuba umphumo uStelara onomntwana ongakazalwa awuzange ufundwe ngokubanzi. Okwangoku kunconywa ukuba uStela kumele asebenzise kuphela ngexesha lokukhulelwa xa kufuneka ngokucacileyo. Ugqirha ochaza ukuba uStera kufuneka adibaniswe ngokukhawuleza ukuba ukukhulelwa kwenzeka.
Ngenxa yokuba kuncinci ulwazi oluninzi malunga nokukhulelwa kunye no-Stelara, nabani na okhulelwe bayacelwa ukuba bathathe inxaxheba kwi-registry yokukhulelwa ngokubiza 1-877-311-8972. Oku kunokunceda oososayensi bafunde kabanzi malunga nendlela uStelara ethinta ngayo oomama neentsana ukuphucula ezinye izigulane kwixesha elizayo.
Ngexesha lokuxiliswa
Kucatshangelwa ukuba uStela unako ukudlula esibilweni sesifuba kwaye ngoko kufuneka athathwe ngumntwana. Ukuncedisa umntwana xa ufumana iStela kufuneka kuxoxwe kunye namalungu eqela lezempilo kwaye kufuneka lenziwe ngokwamntu ngamnye.
ILizwi
I-Stelara isetyenziswe ukususela ngo-2008 ukunyanga izimo ezixhatshaziweyo. Isimo esandula ukuba uSlara avunywe sisifo sesifo sikaCrohn. Nangona i-Stelara ingelaphi unyango, kuye kwaboniswa ukuba iyasebenza ekuphatheni isifo sikaCrohn kwezinye izigulane.
> Imithombo:
> Engel T, Kopylov U. "Ustekinumab kwisifo sikaCrohn: ubungqina obuya kumhla kunye nendawo kwindawo yokwelapha." I-Adv Adv Chronic Dis . 2016 Julayi; 7: 208-214.
> Janssen Biotech, Inc. "Ulwazi loKhuseleko lweSlara." 24 Septemba 2016.
> Levy RA, de Jesús GR, de Jesús NR, Klumb EM. Ukuphononongwa okubalulekileyo kwezi ngcebiso zangoku zonyango lwezifo zesifo se-rheumatic inflammatory during pregnancy and lactation. " Autoimmun Rev. 2016 Oktobha; 15: 955-963.
> Niederreiter L, Adolph TE, uKaser A. "Ulwa-IL-12/23 kwisifo sikaCrohn: ibhentshi kunye nombhede." Iithagethi zeDrrr . NgoNovemba ka-2013; 14: 1379-1384.
> Rocha K, Piccinin MC, Kalache LF, Reichert-Faria A, Silva de Castro CC. "Ukukhulelwa ngexesha le-Ustekinumab Ukwelashwa kwe-Psoriasis eninzi." Dermatology . 2015; 231: 103-104.