Ukuvuvukala kuvame ukudibana ne- rheumatoid arthritis , i- psoriatic arthritis , kunye nezinye iintlobo zesifo samathambo. Ngakolunye uhlangothi, i-osteoarthritis idla ngokuchazwa ngokuthi "ukugqoka nokukrazula" i-arthritis, oku kuthetha ukuba inxulumene nokuguga kunye neenguqu kwi- cartilage . Kodwa ngaba kuhlanganiswe nokuvuvukala?
Ukuvuvukala kunokuba nomsebenzi omkhulu kwi-Osteoarthritis
Kukho ukuziphendukela kwemibandela malunga nokuba kungakhathaliseki ukuba ukutshayala kukubangela i-osteoarthritis, kakhulu kangangokuba ngoku icinga ukuba isifo esivuthayo.
Ukusebenza kwe-immune kubonakala kumalungu afana nomonakalo we-cartilage ophawulekayo lwe-osteoarthritis, ngokuvuvukala kwimbane yokudibanisa, i-synovitis kwaye ikhula.
Kodwa iya kuqhubeka idideka njengoko ikwahluzwa njenge-arthritis engabonakaliyo, ngelixa i-rheumatoid arthritis kunye nabanye babalwa njenge-arthritis evuthayo.
Uhlolo olusisiseko olushicilelwe ngoMeyi 2015 lwaluthi, "I-osteoarthritis yabantu iyinkqubo yesistim e-musculoskeletal ebandakanya ukusebenziselwa kweendlela zokuzivikela ezingenasistim kunye nezilungelelaniso ezihamba kunye nokuvuvukala okuboniswe ngumkhiqizo ophakamileyo wama- cytokines aqhubiweyo, edlala indima ebalulekileyo ekuqhubeni izifo. " Baqhubeka nokucebisa uphando olongezelelweyo kwizidakamizwa ukuvimbela la ma-cytokines ukuphula umjikelezo womonakalo kwi-osteoarthritis.
I-osteoarthritis , eyaziwa nangokuthi isifo esidibeneyo esinobudlova, kubangelwa ukuphuka kwe-cartilage ye-articular - uhlobo lwe-cartilage ehlanganisa iiphetshana zamathambo ngokubambisana.
Ekuhambeni kwexesha, abantu abadala abadala baya kuhlakulela uhlobo oluthile lwe-osteoarthritis (OA) ngokubambisana okanye ngaphezulu kweyodwa, njengamadolo, iinqumlo, umlenze, okanye isandla. Nangona iintlungu ziqhelekileyo kwi-OA, ukuvuvukala ngokucacileyo - ubomvu nokuvuvukala - ngokuqhelekileyo kuthathwa njengesifo esibalulekileyo kunye nezinye iintlobo ze-arthritis.
Nangona kunjalo, njengoko i-osteoarthritis iqhubela phambili, ukuvuvukala kuya kwenzeka malunga nomxube ochaphazelekayo. Kwakucatshangelwa ukuba ukuvuvukala kubangelwa ziqhekeza ze-cartilage eziqhekezayo kwaye zicaphukise i synovium ( ibhondi evulekileyo yentsebenziswano). Nangona kunjalo, i-MRIs ithathwa ngexesha lokuqala kwe-osteoarthritis ngokukhawuleza ifumanisa i- synovitis ukuvuvukala nangona i-cartilage ehlangeneyo isabonakala iqhelekileyo. Oku kubonisa ukuba ezinye izakhiwo ezihlangeneyo nazo zinokubandakanywa ekubangela ukuvuvukala.
Ngaphambi kokuba i-synovitis ibonakale okanye igulo lokuxhatshazwa ngokubambisana liyabonakala, amanqanaba omakishi wokuvuvukala akhula kwigazi kunye kunye nokusetyenziswa kwamanzi. Ezi cytokines ezivuthayo ziquka i-pro-protein esebenzayo (CRP) kunye ne-interleukin-6 kwi-synovial fluid. Icala linamandla ukuba kukho ukuvuvukala okwenzeka kwangaphambili kwi-osteoarthritis kwaye oku kungabangela imbangela yokuqhubeka kweempawu.
Kukho izifundo zakutshanje zokuvuvukala kwi- arthritis yomgudu ebhekise kwi- entheses (ii-sites apho iigaments okanye iithoni zidibanisa nethambo) njengendawo yokubakho ukudibanisa e-OA.
Kubukeka ngathi umbuzo ufana nokuya kuqala, inkukhu okanye iqanda? Ngaba umonakalo owenziwe ngomonakalo ngenxa yokusetyenziswa kakubi okanye ukukhathazeka okubangelwa ukuvuvukala okungapheliyo, okubangela ukulahleka kwe-cartilage ephumela ekulahlekelweni okuqhubekayo, ukuvutha komzimba, synovitis, kunye nokuguqulwa komzimba?
Uphando olungakumbi lukhangele kule mibuzo. Iimpendulo zingakhokelela kwizidakamizwa ezingcono eziza kuphula umjikelezo wokuvuvukala kunye nokuyeka ukunyuka komonakalo kwidibeneyo.
Imithombo:
"Iinguqu zakhe ezitshintshileyo kwii-Complexes 'zeSynovio-Entheseal' Ukucetyiswa iNkqubo yeMveli yeSynovitis e-Osteoarthritis naseSpondylarthritis". UMichael Benjamin noDennis McGonagle. Arthritis & Rheumatism. Novemba 2007.
UJeremy Sokolove no-Christin M. Lepus, "Umsebenzi wokuvuvukala kwi-pathogenesis ye-osteoarthritis: ukufunyanwa kwangoko kunye nokutolika." Ther Adv Musculoskelet Dis . 2013 ngoMatshi; 5 (2): 77-94. i-doi: 10.1177 / 1759720X12467868
Malemud, CJ. "Isiseko se-biologic ye-osteoarthritis: imeko yobubungqina." Curr Opin Rheumatol . Ngo-2015 uMeyi; 27 (3): 289-94. i-doi: 10.1097 / BOR.0000000000000162.