Abanye abantu banezifo ezinobungozi obuphezulu bokusuleleka kuGawulayo kunabanye.
Ukuguqulwa kohlobo lwe-genetic echaphazelekayo nokukhutshwa kwe-HIV kuye kwachongwa phakathi kwee-1990. Eyaziwa ngokuba yi- CCR5-Delta32 ukuguqulwa komzimba, kubonakala kunika ukukhuseleka okunzulu kwi-HIV. Olu tshintsho lomzimba lufumaneka ngokuqhelekileyo kwiindawo ezithile zaseYurophu. Oku kunokwenzeka ngenxa yokuba kwakunxulumene nokuxhathisa kwezinye izifo ezifana ne-smallpox okanye i-Bulonic Plague.
Iprokheni yePk kunye neNtsholongwane kaGawulayo
Ekuqaleni kuka-2009, kwanyatheliswa iphepha elivakalisa ukuba enye inguqu yezofuzo ingaba nezinga lokuchasana ne-HIV. Olu tshintsho luchaphazela izinga lokubonakalisa iprotheni ebizwa ngokuba yiPk. I-Pk ifumaneka phezu kweentlobo ezininzi zeeseli zegazi. Ngokukodwa, kufumaneka kwiinkalo ezahlukeneyo zamaseli anentsholongwane kaGawulayo. Olu pho nonongo olutshanje lufumene ukuba iiseli ezinamazinga aphakamileyo a-Pk zazinzima kakhulu ukusulela i-HIV kuneeseli ezingenayo i-Pk. Iingcali ezifanayo ziye zashicilela uphando olubonisa ukuba abantu abaneempawu (isifo sika-Fabry) esandisa amazinga abo e-Pk kubonakala bengenakuxhatshazwa kuhlobo olulodwa lwe-HIV.
Okuthakazelisayo kukuba ukuchasana kofuzo kuye kwadlala indima ebalulekileyo ekuqhubeni uphando olusebenzayo. Iimeko zesigulane saseBerlin zazibandakanya umntu owanikezwa ngamathambo e-bone marrow evela kumntu onokuguquguquka kweCCR5.
Ukudibanisa unyango lwe-antiretroviral , le nonyango ibonakala ichithe intsholongwane kwinkqubo yakhe. Intsholongwane yayibonakala ichithwe kwi-virus yayo.
Qaphela: Uphononongo luka-2009 luye lwaziswa ngokubanzi njengoko uthe igazi lakho luza kukukhusela kwi-HIV. I-Pk yindlela yokuthayipha igazi. Nangona kunjalo, ayisetyenziswa ngokuqhelekileyo kwaye ayiyiyo inxalenye ye-A / B / O okanye i-Rh typing systems. Ukongezelela, isifundo esicatshangelwayo kuphela sijonge ukukhuselwa kwe- vitro kunye nokufunda kwabo kwangaphambili kubantu abafumene unyango olunye uhlobo lwe-HIV. Ngako oko kubalulekile ukuba ungadluli phambili kwiziphumo zesifundo. Kubonakala sengathi abantu abanezitshintsho ezandisa inani le-Pk baya kunqandwa kakhulu kwi-HIV kunabantu abanamazinga aphantsi ePk. Le ngcaciso inokubakhokelela kwiindidi ezintsha ze-HIV zokwelapha. Nangona kunjalo, ukutsho ukuba uhlobo lwegazi luyakhusela ukusuleleka kuGawulayo lukhulile.
Imithombo:
UDean M et al. Uthintelo lwe-Genetic yokusuleleka kwe-HIV kunye nokuqhubela phambili kuGawulayo ngokususwa kwenkunkuma yeCKR5 yesakhiwo se-Hemophilia Growth and Development Study, i-Multicenter AIDS Cohort Study, i-Multicenter Hemophilia Study Course, i-San Francisco City Cohort, I-ALIVE Study. Sayensi. 1996 Sep 27; 273 (5283): 1856-62.
Galvani AP & Slatkin M. "Ukuphonononga isibetho kunye nengqungquthela njengengcinezelo ekhethiweyo yeCCR5-Delta 32. Proc Natl Acad Sci US A. 2003 Dec 9; 100 (25): 15276-9 .
Lund N et al. "Umntu we-Pk yakhe-blood blood group antigen ukhusela ukhuselo lwe-HIV-1." Igazi. 2009 uJan 12. Epub ngaphambi kokushicilelwa
Lund N et al. "Ukungabikho kwamandla kwiiseli ezivela kwizigulane ezinesifo se-Fabry ukusuleleka kwintsholongwane ye-R5 yabantu." AIDS 2005; 19: 1543-6.
I-Symons J, iVandekerckhove L, uHütter G, i-Wensing AM, i-van Ham PM, i-Deeks SG, i-Nijhuis M. Ukuxhomekeka kwi-CCR5-coreceptor ye-replication replication ichaza ukungabikho kokuhlaselwa kwe-CXCR4-echazwe ngeengxaki ze-HIV kwisigulana saseBerlin. Iiklinikhi ezingenayo. 2014 Aug 15; 59 (4): 596-600. i-doi: 10.1093 / cid / ciu284.