Ngaba iiProbiotics zingathuthukisa i-Asthma?

I-bhakteriya enhle ingaba yinto ebalulekileyo ekukhuseleni i-Asthma

Nangona igalelo leprobiotics kwi-asthma alicaci, ukukhishwa kweli klasi lamachiza ukukhusela kunye nokunyangwa kwe-asthma . Ukulawulwa kwezinto zendalo, ukuhlala ezincinane eziphilayo kunye neziphumo ezincinci ezingabonelela ngesiphumo sempilo esiphumelele kwisifo kunye neempembelelo ezikhulayo kwizigulane kunye noluntu lunqweneleka kakhulu kwizigulane.

Nangona kubekho uphando lwezinto ezincinci ezibonisa iingenelo zonyango kunye neepbiotics kwi-asthma xa ezi zifundo zidibeneyo kwinkqubo yokuhlaziywa ngendlela echanekileyo kunye nokuhlaziywa kwe-meta inzuzo jikelele ayizange ibonwe.

Ngokubanzi, ama-probiotics akakwazi ukucetyiswa okwangoku kunqanda okanye unyango lwe-asthma.

Ziziphi iiProbiotics

Iiprobiotics zihlala zihlala eziphilayo ezincinci (ngokuqhelekileyo iibhaktheriya) onokuzithatha ukunika impembelelo entle kwi-asthma yakho okanye ukunciphisa umngcipheko wokuphucula isifo se-asthma . Ngokuqhelekileyo kuthiwa "ibhaktheriya enobungane" okanye "iibhaktheriya ezintle." Kwimichiza ziqhelekileyo zisetyenziselwa ukukhusela okanye unyango lwehudo olubangelwa ngamayeza. Baye basebenziselwa ubuninzi beemeko zempilo kubandakanywa nesifo sengqondo sesifo sofuba, i-atopic dermatitis (eczema), i-rhinitis ye-allergen (i-hay fever), i-colic, kunye neqanda eliqhelekileyo.

Iiprobiotiki yiyona mveliso yesihlanu yempilo yemvelo esetyenziswa kakhulu kwiintsapho, kodwa ukusebenzisa abantu abadala kuncinci ngokwe-2007 ye-National Health Survey Survey.

Indlela amaProbiotics anokunceda ngayo i-Asthma

I-microflora hypothesis ibonisa ukuba utshintsho kwiibhaktheriya luchaphazela ukuphuhliswa kwesifo se-asthma kunye nesifo esichaphazelekayo.

Ukukhupha ibhaktheriya kucingelwa ukuba kuncedise indlela yokuzivikela kumzimba kunye nokuphazamiseka kwenkqubo echaphazela isifo esiyingozi. Enyanisweni, utshintsho kwi-gutter bactteria lubangele ukuphuhliswa kwe-dermatitis ye-atopic kwaye ziyabonwa ukuba yinyathelo lokuqala ekuphuhlisweni kweempawu zokugula. Ukusetyenziswa ngokweqile kwamagciwane okunciphisa amazinga okuncelisa, kwaye utshintsho ekudleni lukhokelela ekutshintsheni kwi-microflora yegulane kwaye inokunyuka kwimeko yesifo.

Nangona kunzima ukufaka ubungqina, uphando kwizilwanyana lubonise ukuba ukulawulwa kwee-antibiotics kuye kwabangela ukuhamba kwe-air-response.

Izifundo ezininzi zibonise ukuba ukulawulwa kweLactobacillus rhamnosus kunye neLacbabacillus fermentum okanye ngexesha lokukhulelwa okanye kungekudala emva kokuzalwa kukhokelela kwisiganeko se-asthma kunye nezinye izifo ezithintekayo. Nangona kunjalo, uphando oluninzi luye lwahluleka ukubonisa inzuzo efanayo.

Abaphandi abathandekayo baphando babhekiselele kubantwana ababengamazinga ahlukeneyo omngcipheko we-asthma esekelwe kumanani amaninzi ahlukeneyo. Emva koko bajonge "i-poo" yabo okanye isitulo sokuba nobukho beebhaktheriya. Abaphenyi bajonga ukungafani kwiibhaktheriya ezifumaneka kumaqela ahlukeneyo emngciphekweni. Bafumanise ukuba phakathi kwabantwana ababenomqolo kunye nobunzima bokunciphisa amanqanaba eFaecalibacterium, iLachnospira, iRothia kunye ne-Veillonella ibhakteria zitholakala kwisityana xa kuthelekiswa neqela elinomngcipheko omncinci wokuhamba kunye nokugula. Leli qela lalinokuthi lifumaneke li-asthma ngeminyaka eyi-3. Ukungafani kwimixholo yesigxina kubonakala kuphela kwiinyanga ezimbalwa zokuqala zobomi. Oku kufumaniswe kwabangela uphando ukuba baqaphele ukuba utshintsho kwi-bactterial content ezinyangeni ezimbalwa zobomi kunokuchaphazela umngcipheko we-asthma.

Baphinda bacebisa ukuba kunokwenzeka ukuba kuphuhliswe i-cocktail yebhaktheriya ezinokunikwa ngobomi bokuqala ukunciphisa umngcipheko we-asthma.

Abaphandi abathandwayo bezilwanyana banikela iintsholongwane ezikhululekile kwiimfucuza okanye isampuli esisezantsi kumntwana osengozini enkulu yesifo se-asthma, okanye isampuli ngamanqanaba aphezulu aseFaecalibacterium, iLachnospira, iRothia kunye ne-Veillonella ibhakteria. Izilwanyana zavunyelwa ukuba zivelise kwaye abaphandi bazame ukwenza umntwana osondeza abane-asthma. Iigundane ezineebhaktheriya ezongezelelweyo zazingenakuvutha kakhulu kumphunga xa kuthelekiswa namagundane awazange afumane ibhaktheriya eyongezelelweyo.

Nangona isifundo esithakazelisayo, izifundo zezilwanyana aziguquli ngokufanayo kwizifundo zabantu, ngoko nceda ungahambi ucele ugqirha wakho kwisigxina semigodi.

Iiprobiotics ngokuyinhloko zichaphazela i-asthma ngokusebenzisa iqela layo elichasayo.

Nangona kunjalo, zonke iiprobiotics azifani zonke kwaye zingenakho ukuvelisa umphumo ofanayo. Ngenxa yokuba uhlobo oluthile lweprobiotics lunceda ngesifo se-asthma, oko akuthethi ukuba enye uhlobo lweprobiotiki iya kuba nempembelelo efanayo okanye efanayo. Ngokufanayo, ukwahlukana kubonakala kunye neprobiotic efanayo, kodwa yenziwe yinkampani eyahlukileyo. Ngenxa yoko ukuba ufumana iingcebiso kumsebenzi wezonyango malunga neprobiotiki, mhlawumbi kufuneka ufumane igama lokutshintshwa kwegama. Ukuba ufunda malunga nophando lophando kuphela indlela oza kufumana ngayo umphumo ofanayo ukusetyenziswa kweprobiotics ekhankanywe kwinqaku yophando.

Uvavanyo lwezonyango lweeProbiotics Ukusetyenziswa kwiziphumo ze-Asthma

Kwiimvavanyo ezine-randomized of probiotics ekwenzeni unyango lwe-asthma, kukho iziphumo ezininzi. Olunye uphando lubonakaliswe ixesha elide elingenasifo, ngelixa elinye libonise imfuno yokunciphisa i-cromolyn sodium. Olunye uphando lubonise ukuphucuka kwintlanzi yokupasa kunye nokusetyenziswa kweerbiotics.

Ezinye iziphumo zeklinikhi azizange ziphucule kwaye zibandakanya umgangatho wobomi, inani elipheleleyo leengqungquthela ze-asthma, ukusetyenziswa komlawuli okanye imithi yokuhlangula. I-FEV1 ayizange ibonise umehluko omkhulu kwizigulane ezifumana ii-probiotiki xa kuthelekiswa nalabo bafumana indawo yokuhlala.

Ngaba iiProbiotics zikhuselekile

Ngaphandle kwegesi njengezibonakaliso, izigulane zibonakala ziba nemiphumo embalwa kakhulu kwaye zibekezelela iprobiotics. Nangona kunjalo, kukho idatha encinane efumanekayo malunga nokusetyenziswa kwexesha elide leprobiotics okanye ukudibanisa kwamayeza kunye namanye unyango. Kukho iingxelo zeengxaki ezinzulu xa unesistim somzimba esiphelele okanye enye ingxaki yezempilo ngoko kubalulekile ukuxoxa nodokotela wakho ngaphambi kokuqala unyango.

Nangona kungengona yokhuseleko lokwenene, ama-probiotics awalawulwa njengoko kubonwa njengencediso. Ngenxa yoko, akukho nemigaqo eqinile ekulawuleni inkqubo yokuvelisa. Ngenxa yoko, ezinye iiprobioti zifunyenwe ziqulethe iintlobo ezingabhalwanga kwilebula kunye nexabiso elincinci lezinto eziphilayo ngaphandle kwezinto ezifunwayo.

Kwakhona kubalulekile ukuqaphela ukuba ezininzi zeemveliso azilawulwa yi-FDA ngendlela efanayo kunye neyeza zakho eziqhelekileyo ze-asthma. I-FDA izongezelo zempembelelo, kodwa kuba azivunyelwanga njengeziyobisi ezingakhange ziqwalaselwe ngokufanayo. Iiprobiotics ayithwali izibonakaliso ze-asthma njengoko unyango lwakho lwenziwa. Ezi mveliso ziza kungena phantsi kolawulo lwe-FDA ngaphandle kokuba inkampani yenza ibango lonyango okanye kukho imiphumo ecatshulwayo engacetyiswayo yi-FDA. Ukukhuseleka kufuneka uxubushe nayiphi na inkxaso kunye nogqirha wakho ngaphambi kokuba uqale ukuxhaswa kwaye uvumele ugqirha wakho azi malunga naziphi na iziphumo ezichaphazelekayo ozifumanayo.

Funda ngakumbi malunga neNkcazo yokuPhumela isifo se-Asthma

• Iyiphi iMicrotheli eDityanisiweyo kunye neyanye?
• Ginkgo kunye ne-Asthma
• Ingaba yindlela yokuNyango yokuHlola i-Asthma Treatment esebenzayo nekhuselekileyo

_Imithombo

1. > Kalliomäki M >, Salminen > S >, Poussa > T, Arvilommi H >, Isolauri > E. IiProbiotics kunye nokuthintela isifo se-atopic: ulandelelwano lweminyaka emine ye- randomized > trial-controlled control. Lancet. 2003; 361 (9372): 1869-1871.
2. > Weston S, Halbert A, Richmond P, Prescott SL. Ama-probiotics kwi-atermic dermatitis: i > randomized > trial controlled. I-Arch Dis Child. 2005; 90 (9): 892-897.
3. > Pelucchi C, Chatenoud L, Turati F, Galeone C, Moja L, Bach JF, et al. Ukuxhaswa kweprobiotics ngexesha lokukhulelwa okanye kwasebuntwaneni ukukhusela i-dermatitis ye-atopic: uhlalutyo lwe-meta. Epidemiology 2012; 23: 402-14.

4. > Arietta MC, Stiemsma LT, Dimitriu PA et al. Ubusana bentsana kunye nokuguqulwa kwamanzi okuchaphazelekayo kuthintela umngcipheko > ubungozi > bokuphefumula nge-asthma. Inzululwazi yokuguqulela isayensi 30 Sep 2015 >: Vol >. 7, Issue 307, iphe. 307ra152. INGXELO: 10.1126 / scitranslmed.aab2271