I-Niacin (i-nicotinic acid) yipilisi ye-cholesterol-eyanciphayo enokuchaphazela yonke imiba yeprofayili yakho yepilid , ngokukodwa, uphando lubonise ukuba i-nicotinic acid ingakwazi:
- Ukwandisa amazinga e- HDL ngama-25%
- I-cholesterol yeLDL engaphantsi kwe-35%
- I- triglycerides engaphantsi kwe-50%
Nangona unako ukufumana i-niacin eyongezelelweyo (i-nicotinic acid) ngomyalelo, kukho ezinye iifom ze-niacin ezifumanekayo ngaphandle komyalelo kwaye zingabizi kakhulu.
Nangona i-niacin ingasidingi ukutyelela umboneleli wakho wezempilo ukuze ufumane imithi, oku akuthethi ukuba kuphephile ngokupheleleyo ukuyithatha. Uphando olutshanje, olukhulu (uphando lwe-AIM-HIGH) luveze ukuba abantu abaneentsholongwane ze-cardiovastic bathatha ukukhululwa kwe-niacin kwenyuka kwanda amazinga e-HDL - kodwa abazange babone ukunciphisa umngcipheko wokuba nesiganeko senhliziyo-esinjenge-stroke okanye isifo senhliziyo - okanye ukufa. Enyanisweni, akukho mahluko phakathi kwabantu abathile kulolu cwaningo oluthatha isitembu kunye ne-niacin ngokubhekiselele ekuthathweni komfanekiso. Ukongezelela, abantu abathile bathatha iicicininic kulesi sifundo babeneziganeko eziphezulu zezibetho zesichakam. Ngenxa yokuba kwakungekho utshintsho engozini yokufa okanye iingxaki ezivela kwisifo senhliziyo kunye nenkxalabo ngenxa yokwanda kweentlanzi, abaphandi baye bayeka le ngcaciso ekuqaleni.
Iziphumo eziqhelekileyo ezichazwe nge-niacin zibandakanya isikhumba, ukucabisa, ukutshisa okutshisa kunye nentliziyo.
Nangona kunjalo, ezinye iziphumo eziphambili ziyakwenzeka, kwaye unokwandiswa ukuba unenye yeemeko zonyango ezilandelayo:
- I-Gout - i-Niacin inokunyusa amanqanaba e-uric acid, ukwandisa amathuba okuba uhlaselwe ngokuhlaselwa.
- Isifo sikashukela - I-diabetics ethatha i-niacin inokuthi ibone ukwanda kwezinga lokushukela egazini legazi.
- Isifo sesilonda se-Peptic - Izifundo ezihlola ukusetyenziswa kokukhululwa kwe-nicotinic acid zineengxelo zokuphuhliswa kwesilonda sezilonda. Inkqubo eyenziwa yiyo ayiyaziwa.
- Isifo sesibindi - Ukuthatha i-niacin kunokubangela ukwanda kwenzululwazi yesibindi, enokuthi iphakame ngakumbi kubantu abaye bafumana isifo sesibindi.
- Izifo zengqondo - Ukuba nomsebenzi ongeyimpembeko kungabangela ukuba i-niacin iqokelele kwigazi lakho, mhlawumbi nemiphumo emibi.
- Ukukhulelwa - Akukho zifundo ezaneleyo zokuvavanya ngokwaneleyo ukhuseleko lwe-niacin kwintsana yakho. Ngoko ke, kufuneka uqhagamshelane nomboneleli wakho wezempilo ukuba ukhulelwe, okanye uceba ukukhulelwa.
- Isondlo sesisu - Izifundo zibonise ukuba i-niacin idityaniswe ubisi lwebele, nangona kunjalo, ayikwazi ngokupheleleyo ukuba amayeza anikwe i-cholesterol engaphantsi ayenokulimaza umntwana.
- Isifo se-Cardiovascular disease - Ukuthatha i-niacin kunokudambisa ezinye iimeko zesifo senhliziyo, njenge-angina engaqinisekanga.
- Iziphazamiso zokubhabha - Ukuthatha iimveliso ze-niacin kunokunciphisa amandla akho okugquma-kwaye ukwandise amandla akho okuphuma. Oku kuya kwenzeka nokuba uthatha i-anticoagulants, okanye "abagcini begazi", njengeCoumadin (warfarin) okanye i-aspirin.
Kwiingcaphephe, abanye abantu abathatha i-niacin bavumelekile ukunciphisa umthamo okanye kubangele ukuba i-niacin ishiywe ngenxa yemiphumo emibi.
Ngenxa yeziphumo ezibi kakhulu kunye nokungabikho kwenzuzo kwimpilo ye-cardiovascular, i-niacin ayinconywanga njengamayeza athathe ukuba ufuna ukunciphisa izinga lakho leepidid. I-Niacin inokuthi ithathelwe ingqalelo ngumboneleli wakho wezempilo ukuba awukwazi ukulawula ngokupheleleyo amazinga akho e-lipid kunye namanye amayeza - njengokuthatha i-statin yedwa okanye i-statin kunye ne-ezetimibe inhlanganisela.
Ngoko, ukuba ukhangele ukufaka i-niacin kwi-regim-downing regimen, khuluma nomboneleli wakho wezempilo kuqala. Unakho ezinye iindlela zokunciphisa ngokukhuselekileyo i-cholesterol yakho kunye ne-triglyceride, kwaye emva koko unokuqwalasela i-niacin ukuba ezinye iindlela zokwelapha azisebenzi.
Imithombo:
Micromedex 2.0. I-Truven Health Analytics, Inc. iGreenwood Village, CO. Iyatholakala kwi: http://www.micromedexsolutions.com. Ufikelele ngoFebruwari 10, 2016
UDipiro JT, uTalbert RL. I-Pharmacotherapy: Indlela yePathophysiological, 9th 2014.
Abaphandi be-AIM-HIGH. I-Niacin kwizigulane ezinezinga eliphezulu ze-cholesterol ze-HDL kunye nokufumana unyango olunzulu lomzimba. N Eng J Med 2011; 365: 2255-2267.
Stone NJ et al. Izikhokelo ze-ACC / AHA ze-2013 zokunyanga kwe-cholesterol yegazi ukunciphisa ingozi ye-atherosclerotic engqondweni yabantu abadala. Ukuhamba ngo-2014; Ukujikeleza 129 (25 iSondlo 2): S1-45