Kuphando olusandulwe kutshanje, izazinzulu ziye zafumanisa ukuba abantu abane- reflux isifo se-gastroesophageal (GERD), ngokukodwa abo abaneenkcukacha ze-GERD ezibizwa ngokuba yi- Barretts esophagus , baye batshintshela iiseli kwindawo yabo equkethe i-telomeres efutshane, ukulandelwa kokuphela kwi-DNA. Iziphumo zolu phando zibonisa ukuba ukulandelelana okufutshane kufanele kuvumele ezinye iiseli zilungele umhlaza ukuba zithathe.
Ngokutsho kukaDkt. Rhonda Souza, uprofesa odibeneyo we-medicine yangaphakathi, uT.-Southwestern, Uphando lubonisa ukuba kutheni kubalulekile ukukhusela i-reflux, kuba i-reflux engaphezulu kwaye unayo ixesha elide, ngakumbi kunokukubeka phambili ukufumana i-Barretts esophagus . Ngoko ufuna ukukhupha loo reflux.
Xa i-GERD ingahambelwanga okanye ingaphathwa kakuhle, isisu se-asidi sinokuhlala siphinde siphinde siphinde siphakamise kwi-esophagus. Xa kwenzeka le nto, kunokudala iiseli eziqhelekileyo ezinjengesikhumba kwisigxina ukuba zitshintshe zibe ziqine, ii-cell ezingamelana ne-acid ezinjengezo zifunyenwe esiswini nasemathumbu. Xa oko kwenzeka, isigulane sifumaneka nge-ah imeko ebizwa ngokuba yi-Barretts esophagus.
I-Adenocarcinoma yesisu, umhlaza obandakanyeka ngakumbi ne-Barretts esophagus, ngoku kungumdlavuza okhulayo ngokukhawuleza e-US, unyuke ngokuphindwe kabini kwiimeko kwimihla engama-30 edlulileyo, ngokweNational Cancer Institute.
Abaphandi baqhathanisa ubude be-telomere kunye nomsebenzi we-telomerase kwiimpawu ze-biopsy ezivela kwizigulane ezingama-38 ezineGERD kunye nezigulane ezili-16 zokulawula. Lo mgca omtsha wophando ubonisa ukuba i-acid eqhubekayo ye-aclux echaphazela amangqamuzana e-esophageal abangela ukuba bahlule ngokuphindaphindiweyo ukwenzela ukuba bahlaziywe kwakhona.
Nangona kunjalo, ngalunye ixesha iiseli zahlula, i-telomeres ekupheleni kwe-DNA ziba mfutshane. Xa beba mfutshane kakhulu, iseli eligugayo alinakukwazi ukwahlula, uDkt. Souza uthe.
Inzululwazi igxeka ukuba xa amaseli engakwazi ukwahlula, ezinye iiseli zingangena ngaphakathi kwendawo ukuze zenze ilahleko. Kwaye loo maseli inokuthi ikwazi ukuvelisa i-acid-resistant-resistance which makes them more likely to turn cancer.
Izibonelelo ezihambelanayo:
Izifo ze-Reflux ze-Gastroesophageal
Isifo se-reflux se-Gastroesophageal (GERD), esaziwa nangokuthi isifo se-aclux acid, senzeka xa i-sphincter esezantsi (i-LES) ingasondeli kakuhle kwaye isisu esiswini siphumelele, okanye siphumelele kwisigxina.I-Barrett's Esophagus
Isibonda sikaBarrett yimeko apho isishubhu, ityhubhu ye-muscular ephethe ukutya kunye namathele emlonyeni ukuya kwisisu, utshintsho ukuze ezinye zazo zitshintshwe luhlobo lweethambo ezinjengezinto eziqhelekileyo ezitholakala emathunjini. Le nkqubo ibizwa ngokuba yi-intestinal metaplasia.Canophageal Cancer
I-adenocarcinoma ye-Esophageal ngumdlavuza okhawulezayo kwihlabathi lasentshona. Imiba enkulu yemingcipheko yomhlaza ngumhlaza we-Gastroesophageal Reflux Disease (GERD) kunye ne-Barrett's oopopus.