Iziyobisi zonyango zibonelela ngefuthe elichasayo kwizifo ze-rheumatic
Imishanguzo ye-cytotoxic eqhelekileyo isetyenziswe ukuphatha izifo zengxubusho ziquka:
- Azathioprin (Imuran)
- Cyclophosphamide (iCytoxan)
- I-Methotrexate (iRheumatrex okanye i-Trexall)
Ezi zi yobisi zabizwa ngokuthi "i-cytotoxic" kuba ziphatha izigulane ngokubulala ngokuthe ngqo iiseli zesisu. Ukukwazi kwabo ukunceda iimpawu kunye neempawu zezinye izifo, njenge- rheumatoid arthritis , i-lupus kunye ne- vasculitis , nangona kunjalo, ngenxa yeempembelelo zabo ezichasayo ngokuchasene nokukwazi ukubulala amaseli.
Enyanisweni, umthamo ophantsi we-methotrexate osetyenziswe ukunyanga le miqathango ngokwenene inxamnye ne-inflammatory and not cytotoxic.
Izinzuzo kunye Neengozi zeMithi e-Cytotoxic kwi-Rheumatic Diseases
ICytoxan
Kwezi zintathu iziyobisi, i-Cytoxan ineempembelelo ezinokubakho kakhulu kwaye ngokuqhelekileyo iyancitshiswa ekuphatheni amanyathelo athatywayo ama-lupus, vasculitis, okanye imiphunga yamanye amaxesha anxulumene ne-rheumatoid arthritis, myositis kunye ne- scleroderma .
Ixhalaba elikhulu ngeCytoxan ngumngcipheko wokudakumba komnxeba onokunyusa ingozi yokusuleleka okanye ukuphuma kwegazi. Ukongezelela, kukho umncinci omncinci kodwa ocacileyo wokuba nomhlaza obandakanya ulusu kunye nesikhumba. Ezinye izigulane zinokuphuhlisa imeko enobunzima bladder ebizwa ngokuba yi-cystitis interstitial. Ukuba isigqirha sinikezwa ngomlomo, ukutya kwamanzi rhoqo kunye nokucoca kunokunceda ukukhusela le ngxaki. I-Cytoxan idlalwa rhoqo ngama-infusions angaphantsi kwenyanga angasinceda.
Isilwayo sisifo se-teratogenic (sinokubangela iziphene zokuzalwa xa kuthathwa ngexesha lokukhulelwa) kwaye kufuneka zikhutshwe kwabasetyhini abangasebenzisi ulawulo lokuzalwa ngokufanelekileyo okanye ngubani onokukhulelwa. Ekugqibeleni, kunokubakho ubuncipheko obunciphekileyo bokusuleleka kakubi kwi-Cytoxan.
Imuran
I-Imuran ivunyiwe yi-FDA ye-arthritis ye-rheumatoid kwaye isetyenziselwa ukuphatha i-lupus nezinye izifo zenyama.
Kudibaniswa nomngcipheko wokudakumba komnxeba kwaye unokunyusa ukwanda komngcipheko wamanye amagciwane. Kukho umngcipheko okhulayo wokufumana isifo esinzulu xa uthatha le nkunkuma.
Methotrexate
I-Methotrexate ivunyiwe yi-FDA ye-arthritis ye-rheumatoid kwaye ingaba luncedo kwezinye izifo zesisu ezifana ne-lupus, myositis kunye ne-vasculitis.
Ngelixa i-methotrexate ingaba nemiphumo efana neyofana nezinye iziyobisi, kubonakala kunesiprofayili engcono. Efana neCytoxan, itekatecenic kwaye ayifanele isetyenziswe ngabasetyhini kunye namaqabane abo ukuba ayisebenzisi ulawulo lokuzalwa ngokufanelekileyo okanye kukho ithuba lokukhulelwa.
Ukongezelela, isilwanyana sinxulumene nomngcipheko omncinci wesifo somphunga (i-pneumonitis yangaphakathi) engasongela ubomi ukuba isigulane singagcini isiza kwaye siphathwe. Ngokuqhelekileyo, iimpawu zengxaki ziquka ukuphefumula, ukukhwehlela oomileyo kunye nomkhuhlane. Njengaye amanye amachiza amayeza, kunokubakho ubuncipheko obuninzi bokusuleleka.