Ngaba kukho uxhumano phakathi kwe-Pathology ye-AD kunye neNtsholongwane yakho yokuNuka?
Yuck! Yintoni ephosakeleyo? Ewe, ngokutsho kwabaphandi abathile, ukukwazi kwakho ukuphendula loo mbuzo unokuqikelela ukuba amathuba akho ekuhlaleni isifo se-Alzheimer .
Uninzi lwezifundo zophando kwiminyaka engama-20 edluleyo lubonise ukuxhamla phakathi kokungakwazi ukufumana ukuvumba nokunciphisa ukuqonda. Zininzi zale zifundo zibonise ubudlelwane bokuqhelana apho ukungahambi kakuhle komntu ongenakho ukuphefumula komzimba kwangaphambili kwandise ukuba amathuba abo bantu abanjalo bavelise iimpawu zesifo se-Alzheimer ngokuhamba kwesikhathi.
Ngokomzekelo, olunye uphando olubandakanya abantu abadala abangama-3 000 phakathi kweminyaka engama-57 kuya kwe-85 kunye nokuqonda okuqhelekileyo abaye bafundiswa kwiminyaka emihlanu. Abaphandi bafumene ukuba ukunciphisa amandla okuchazela umahluko phakathi kokuvumba kwakuxhamle ngokuphindaphindiweyo umngcipheko wokuba ne-dementia.
Abaphandi baye bajonga nokukhubazeka okunengqiqo . Ukukhubazeka okunzulu kwengqondo yimeko apho abantu banenkinga enkulu ngemisebenzi yokukhumbula , ukugxininisa, ukuxhomekeka , kunye nezakhono zonxibelelwano ezifana nezakhono zokufumana amagama . Ezinye, kodwa kungekhona zonke, iziganeko zenkqubela yokuphazamiseka kwengqondo e-Alzheimer.
Kwisifundo seminyaka emihlanu, izazinzulu zilandele abantu abangama-589 abahlala emakhaya abo. Akukho nxaxheba kwababenokukhubazeka okucacileyo ekuqaleni kwesi sifundo. Ukusebenza kwengcamango yomntu ngamnye kunye nokukwazi kwabo ukufumanisa ivumba kuye kwavavanywa ekuqaleni kweso sifundo, kwaye emva koko emva koko.
Iziphumo? Abathathi-nxaxheba abonise ubunzima ekufumaneni izivumba ezinamava awancipha amanqaku kwiimvavanyo zokusebenza kwengqondo. Ngamanye amazwi, ukungakwazi ukuchonga izivumba ezichazwe ukuba ngubani oza kuvelisa iimpawu zokukhubazeka okucokisekileyo.
Ezinye iziphumo ziye zafumanisa ukuba ukusetyenziswa okusemgangathweni okulindelekileyo kunqabile ukuhla kwexesha elizayo kwizikolo ze- MMSE kwaye ukukwazi ukuqonda izivumba kwakunxulumene ngokufanelekileyo kunye nokukhumbula okulibalekile , ukuthetha ngomlomo , ikhono lokubona i-visuospatial , kunye nekhono lokuqonda.
Yintoni Ebangelwa Ukuba I-Smell Ichaphazelekayo Kwizifo Zama-Alzheimer?
Yintoni ebangela ukulahleka? Izifundo zibonakala zibonisa ukuba umonakalo weflethi uphathwe ngokubonakala kweprotheni ye- beta amyloid kwimimandla yengqondo eyasinceda sibone kwaye sibone iphunga. Olunye uphando lubonisa ukuba le mimandla yengqondo yilapho iprotheni iqokelela kuqala, iphazamise umqondo wokuhogela phambi kokusebenza kwengqondo.
Izifundo ezininzi ziye zabonisa ukulungelelanisa okuphezulu phakathi kwesifo se-Alzheimer kunye nesakhiwo seprotein ye-pathology kwinkqubo ye-olfactory (yethu ingqondo yokunuka).
Uphononongo olunye luye lwahlaziya iziphumo ze-130 ze-autopsies kwaye zafumanisa ukuba kuzo zonke izifo zesifo esiqinisekileyo se-Alzheimer, kwakukho i-tau pathology kwinkqubo ye-brain.
Ucwaningo lwesibini lufumanise ukuba ekuphononongweni kwama-autopsies angama-273, kukho ukulungelelaniswa okuphezulu phakathi kwendawo yokwakha ye-tau kwi-system yolfactory kunye nobukho bomonakalo wengqondo obuhlobene nesifo se-Alzheimer.
Izifundo zibonisa ukuba njengoko isifo se-Alzheimer siphuthuma, ukukwazi ukunuka kwamanzi kuya kunciphisa.
Ingaba Ukulahlekelwa Kokugqithisa Kuphuhliswe Ngezinye Iintlobo Zengqondo?
Abaphandi baye bafumanisa ukuba i-Alzheimer's disease kunye ne- Lewy yokugula komzimba kubonakalisa imiphumo ebalulekileyo kwintswelo, ngelixa abantu abanezifo ezihamba phambili ne- corticobasal deeraleneration babonisa ukungabikho komonakalo.
Ngaba Ukuguga Kungaba Isizathu Sokuba Ukunuka Kuye Kunciphisa?
Naphezu kokubakho ubungqina obunokubonakala bukhona, inqaku elinye lophando liphakamisa imibuzo. Kule sifundo, izazinzulu ziphonononge izifundo ezininzi eziye zaqhutyelwa ngentsingiselo yokunuka kunye nokudibanisa kwayo ekunciphiseni kokusebenza kwengqiqo kwaye yagqiba ukuba uphando oluninzi lwahluleka ukubonisa ubungqina obuqinileyo ngenxa yoyilo lwezifundo. Enye yezinto ezixhalabisa kukuba, njengabantu abaneminyaka yobudala, umva wokunuka kwenkohlakalo. Ngoko ke, uphando lwezophando kufuneka luthathe le ngqalelo ukuze uphando lubonakalise ukuba ukungakwazi ukufumanisa ukuvumba akubangelwa yiminyaka yobudala kodwa kunokuba yinkqubo ebuchosheni ehambelana nokulahlekelwa kwemisebenzi engqondweni.
Ngokusekelwe kwisixa esibalulekileyo sophando oluye lwaqhutywa, nangona kunjalo, kusenokwenzeka ukuba kukho umyinge phakathi kwengqondo ephosakeleyo yokunuka kunye nokuncipha kwengqondo.
Ngaba Ufanele Uvivinye Ingcinga Yakho Yokumnyama Ukufumana Ukuba Usemngciphekweni We-Dementia?
Uvavanyo olumnandi olunqwenelekayo alukhuthazwa njengendlela yokuchonga abo basengozini yokudemeka kwengqondo ngeli xesha, nangona kunokwenzeka ukuba ingafakwa njengenxalenye yebhethri yeemvavanyo. Into enokuvelisa ngakumbi ngeli xesha ijolise kwizinto onokuzenza ukunciphisa umngcipheko wokuhlaziya ingqondo, njengengqondo yomzimba, ukuzivocavoca umzimba kunye nokutya okunempilo.
ILizwi
Ukuba ukhathazekile ngememori yakho kwaye ubona ukuhla kwekhono lakho lokufumanisa okanye ukufumanisa ukuvumba, ungathatha ukuhlolwa kwekhaya kwanjengokuhlolwa kovavanyo lwe- SAGE . Qinisekisa ukuba ucwangcise i-aphoyintimenti yokuxoxa ngeziphumo zakho kunye nodokotela, njengoko kukho izizathu ezininzi zokulahlekelwa kwememori, kunye neenzuzo ezininzi ukufumana kwangaphambili ukugula komqondo.
Imithombo:
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> Goette, W., Werry, A. kunye noSchmitt, A. (2017). Ubudlelwane phakathi koBuchule beNkcukacha kunye neNeopsychological Domains: Iziphumo ezivela kwiSample of Adult-Residential Adultes. Umbhalo we-Clinical and Experimental Neuropsychology , iphe.1-11.
ILaryngoscope. Umqulu 122, i-Issue 7, iphepha 1455-1465, ngo-Julayi 2012. Ukuvavanywa koLwazi oluchanekileyo njenge-Predictor of the Development of Almheimer's Dementia: Uhlolo lokuHlola. http://onlinelibrary.wiley.com/doi/10.1002/lary.23365/abstract.
Isizwe seSizwe sokuguga. Intuthuko ekufumaneni izifo ze-Alzheimer's. http://www.nia.nih.gov/alzheimers/publication/2011-2012-alzheimers-disease-progress-report/advances-detecting-alzheimers#.UnJOohAhGoY
> Reijs, B., Ramakers, I., Elias-Sonnenschein, L., Teunissen, C., Koel-Simmelink, et al (2017). Ulwalamano lwe-Odor Ukuchongwa kwezifo ze-Alzheimer's Markers kwi-Cerebrospinal Fluid kunye noCognition. I-Journal ye-Alzheimer's's disease , 60 (3), iphe. 1025-1034.
> Tonacci, A., Bruno, R., Ghiadoni, L., Pratali, L., Berardi, N., et al (2017). Ukuvavanya ngokucacileyo kwiNgxaki eNgqiqo enokuqonda: Ukulungelelaniswa ngokuSebenzisana kweNkqubo neSebenzi yokuQiniseka kweMpilo. I-European Journal ye-Neuroscience , 45 (10), iphe.1279-1288.
Psychiatry yokuguqulela. 2012 NgoMeyi, 2 (5), e118. Ulwahlulo olucacileyo luchaza ukuhla kweCognitive phakathi kwabantu abadala abakhulileyo. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365262/.