Indima ye-Cannabinoids kwiCancer Care
I-Cannabis sativa , eyaziwa ngokuqhelekileyo njengesityalo se-marijuana, inomlando omdala kwiyeza. Enyanisweni, kukho ubungqina obubhaliweyo bokusetyenziswa kwonyango lwe-cannabis eChina okuthandana neminyaka engama-5 000 edlulileyo. Kwacetyiswa ngezifo ezininzi ezivela kwisifo sohudo kunye neengqungquthela zokusongela isisu kunye nokuxinwa kwesifuba, kwaye sasebenzisa njenge-aphrodisiac, intlungu yesifo kunye ne-anesthetic.
Njengoko ulwazi lwethu ngomzimba womntu kunye nezifo zikhula, ngokunjalo ukuqonda kwethu kula mayeza asendulo. Iyiphi indima i-cannabis edlalayo kunyango lwe-leukemia okanye i-lymphoma isigulane?
Ziziphi iindawo ezingenakukwazi ukuzenza?
Isityalo se- Cannabis sativa sivelisa ama-compounds angaphezu kwe-70 eyaziwayo njenge-cannabinoids. Ngelixa i-60 yalezi zinyango ezingasebenzi kwaye zinefuthe elincinci kumsebenzi weebrazi zethu, ama-composites aseleyo anokuba namandla kwaye oku kusetyenziswa unyango ukuphatha ezininzi iimpawu.
Eyona ndlela inamandla kakhulu yilezi zinkozo zokubulala i- tetrahydrocannabinol (i-THC) , i-agent esebenzayo kwi-marijuana. Ukufunyanwa kwe-THC kuma-1960 kubangela ukuphuhliswa kwamachiza, i-dronabinol (i-Marinol), i-nabilone (i-Cesamet), i-Sativex, i-Levonantradol kunye ne-Synhexyl esekelwe kwiifom zokwenza izinto ze-THC.
I-Cannabinoids Work?
Oogqirha babemisela i-cannabinoids ngaphambi kokuba baqonde kakuhle indlela abasebenza ngayo.
Ukususela ngelo xesha, abaphandi baye bafumanisa i-receptors emibini emizimbeni yethu apho isenzo sokunqanda. Zibizwa ngokuba yi-receptor ye-cannabinoid 1 (CB1) kunye ne-receptor 2 ye-cannabinoid (CB2).
I-CB1 yi-receptor ekhoyo ngokuyinhloko kwinkqubo yethu yentsholongwane edlala indima ekunyukeleni, ukuhlanza nokuxhalabisa, kwaye yinto echaphazelekayo yi-cannabis ne-THC.
I-CB2 itholakala kwezinye izicubu zomzimba kwaye idlala indima kumasosha omzimba wethu .
Iinnabinoids zivuselela ezi zamukeli, ekugqibeleni zikhokelela ekuphumuleni kweempawu.
Yintoni Inokuthi Iingenabinoids Zenzani Kum?
Okwangoku, i-cannabinoids ivunyiwe ukuba isetyenziswe kwizigulane zomhlaza kunye nokuhlanza okungaphendulanga kwindlela yokwelapha ngokuqhelekileyo , kunye nokukhuthaza ukutya kwizigulane ezine-HIV / HIV. Ucwaningo lwezonyango luye lwabonisa ukuba unyango lwe-cannabinoid lungasebenza ukulawula inani leempawu kwisigulane somhlaza:
- Ukuxinezeleka
- Ukuxhalabisa
- Ubuhlungu
- Ukuhla ukusinda
- Ukulala kakubi
Ukongezelela, uphando luyaqhubeka ukuqinisekisa ukuba imichiza echaphazela i-CB2 (immunity) receptors ingabulala iiseli zomhlaza.
Kubalulekile ukuqaphela ukuba unyango lwe-cannabinoid alusebenzi kuwo wonke umntu, kwaye ngamanye amaxesha iimiphumo ezingalunganga zidlula inzuzo yesilwanyana. Ukuba ufumana isicarucu kunye nokuhlanza ongeke ulawulwe, okanye ucinga ukuba unokufumana inzuzo yonyango le-cannabinoid, uthetha kumsebenzi wakho wezempilo.
Ziziphi Iimpawu Zingalindeleki?
Njengoko nayiphi na imishanguzo, i-cannabinoids ingabangela imiphumo emibi:
- Ukulala
- Ukudideka
- Uxinzelelo lwegazi oluphantsi
- Umlomo omile
Ezinye izigulana ezithatha i-dronabinol zinokufumana "ukuphakama" okufana nokuvakalelwa okuhamba kunye nokubhema i-marijuana.
Imiphumo emibi yeempembelelo ze-cannabinoids ngokuqhelekileyo ihambelana nemilinganiselo ephezulu kwaye inganciphisa njengoko uqhubeka ukuyithatha.
Ziyakuthatha njani ii-Cannabinoids?
Uninzi lwama-cannabinoids luthathwa ngomlomo kwipilisi okanye kwifomsule ifomu. Isenzo sale mayeza singathatha ixesha lokunika uncedo, ngoko ke ukuba uthatha la mayeza ukuba ukhulule intlungu okanye isicathulo, uya kufuna ukuhlala kwishedyuli ngokuqhelekileyo kwaye ungalindelanga ukuba iimpawu zakho ziphume ngaphandle kokuthatha .
I-Sativex, inhlanganisela ye-THC kunye no-50/50 kunye nelinye i-cannabidol ebizwa ngokuthi i-cannabidiol, yinto ephuma kumlomo wakho okanye ngaphakathi kwidama lakho.
Ukuqala kwezenzo ze-Sativex kukhawuleza kunezinye iintlobo ze-cannabinoids.
Kuthiwani NgeMarjuana?
Xa amayeza angenayo i-cannabinoid adalwe ebhodini, yenziwa ukuhlangabezana nezikhokelo ezilawulwa ngokuthe ngqo kwihlabathi. Ezi mfuneko zinceda ukuqinisekisa ukuba umphumo wokugqibela uphephile kwaye usebenza. Ngokuxhomekeke kwindlela kwaye izityalo ze-cannabis zikhulile ngayo, i-marijuana ingahluka kakhulu kwi-batch ukuya kubheki kwaye ayikwazi ukulandela nayiphi na izikhokelo zokukhusela. Ukongezelela naziphi na iinkxalabo ezinokuphakanyiswa kunye nendlela eyiyo ngayo imveliso, kunokukho nokuba naluphi na inani lokungcola okwangoku kukhokelela kwimiphumo emibi okanye ukusuleleka xa ukhutshwa.
Ngaphandle kokungekho mthethweni kwiindawo ezininzi, ukutshaya i-marijuana kunokukhokelela ekucasuleni imiphunga, kwaye, ngokweminye uphando, kungabangela umdlavuza .
Ukuyifumanisa
Nangona i-marijuana yonyango iye yaziwa kwiimidiya kwiminyaka embalwa edlulileyo, i-cannabis sativa isetyenziselwe ukunyamekela isigulane iminyaka eyiwaka. Njengoko sifunda ngakumbi malunga neenzuzo zezinye iifom equlethwe kwi-cannabis, izazinzulu zizama ukuhlukanisa kunye nokuhlambulula le michiza ukuze isebenze ngokukhuselekileyo.
Imithombo
Guy, G., Stott, C. "Ukuphuhliswa kweSativex- unyango lwe-cannabis based" e-Mechoulam, R. (ed) (2005) I- Cannabinoids njenge-Therapeutics uBrakhauser Verlag: iBasel, eSwitzerland. (iphe. 231- 263).
UHanus, L., Mechoulam, R. "I-chemistry ye-Cannabinoid: i-Overview" e-Mechoulam, R. (ed) (2005) I- Cannabinoids njenge-Therapeutics eBrakhauser Verlag: iBasel, Switzerland (iphepha 23- 46).
I-Musty, R. "I-Cannabinoids kunye nexhala" e-Mechoulam, R. (ed) (2005) I- Cannabinoids njenge-Therapeutics uBrakhauser Verlag: iBasel, eSwitzerland. (iphe. 141- 147).
Petrocellis, L., Bifulco, M., Ligresti, A., Di Marzo, V. "Ukusetyenziswa okungenakusetyenziswa kwe-cannabimimetics kunyango lomhlaza" eMechoulam, R. (ed) (2005) I- Cannabinoids njenge-Therapeutics uBirkhauser Verlag: iBasel, Swizalend. (iphe. 165- 181).