Ingaba kukho udibaniso phakathi kwe-estrogen nomdlavuza wamaphaphu? Siyazi ukuba kukho ukungafani phakathi komdlavuza wamaphaphu kwabasetyhini kunye nomdlavuza wamaphaphu kumadoda. Siyazi kwakhona ukuba iseli somhlaza wamaphaphu unemitholampilo ye-estrogen, oko kukuthi, indawo ezingaphezulu kweseli ezinokubambisana ne-estrogen. Nangona ulwazi lwethu alukugqibeli ngeli xesha, oko kuthetha ntoni kubafazi abanomdlavuza wamaphaphu namhlanje, okanye abasengozini yomdlavuza wamaphaphu esikhathini esizayo?
Ngaphambi kokuthetha ngezifundo, kunceda ukuchaza isizathu sokuba ezinye zeziphumo zidideke kakhulu. Kukho iindlela ezininzi ezahlukeneyo (iindlela) apho i-estrogen inendima kumdlavuza wamaphaphu. Kwakhona kubalulekile ukubonisa ukuba ezininzi zezi zifundo zixoxa malunga nemiba emibini ehlukeneyo. Enye ibangela-mhlawumbi izinga eliphezulu okanye eliphantsi le-estrogen linempembelelo malunga nokuba umntu uya kuba nomdlavuza wamaphaphu kwindawo yokuqala? Enye enye inkqubela-i-estrogen ingabangela umdlavuza wamaphaphu osele ukhona ukukhula ngokukhawuleza okanye ngokukhawuleza?
Imbali yokuzala
Nangona siqonda ukuba umdlavuza webele uqhelekileyo kubasetyhini abaqala ukuba namaxesha asemncinane, uphando alufumananga ukuba kunjalo nangomdlavuza wamaphaphu. Umdlavuza womlenze wacingelwa ukuba awuncinci kubafazi ababenabantwana abangaphezu kwalabo ababenabantwana abancinci okanye akukho nanye, ngakumbi kubasetyhini abangazange bavume.
Ukuphononongwa kwangoku kweengxelo ukuya kutsho kubonisa ukuba umhlaza wesifo somhlaza wamangqamuzana , kodwa kungekhona umdlavuza omncinci wamangqamuzana , ungabonakali kangangoko kubasetyhini abanabantwana abaninzi. Olunye uphando lwafumanisa ukuba, ngokuchasene nomdlavuza webele, umngcipheko womhlaza wamaphaphu wawuncinci xa abafazi bebeletha emva kweminyaka.
(Xa kuthelekiswa, umhlaza wesifuba uncitshiswa ngokuba nomntwana wokuqala ebomini (ngaphambi kwe-30) kodwa ingozi yomhlaza yemiphunga iyancitshiswa ngokuba nomntwana kamva ebomini.)
Uphononongo olutshanje lubonisa ukuba abasetyhini abanesibini amaqanda abo basuswe ("ukutshatyalaliswa komxhesho") kunokuba nomngcipheko ophezulu wokuba nomdlavuza wamaphaphu. Ezinye izifundo ziye zabonisa ukulungelelanisa okufutshane phakathi kokusuka kwexesha lokuqala kunye nokuphuhliswa komhlaza wemiphunga.
Studies Studies
Olunye uphando malunga namagundane lucetyiswa ukuba i-estrogen inokukhuthaza ukukhula kwamanomdlavuza emiphunga. Kuloo sifundo, iigundane zowesifazane ezazinamaqanda aphucula izidumbu zamapomfini ngaphezu kwamagundane amabhinqa awathatywe amaqanda awo. Ukongeza, xa amagundane angenawo amaqanda aphethwe nge-estrogen, izicubu zabo zakhula ngokukhawuleza kunezondlo ezingazange ziphathwe nge-estrogen.
IHormone Alternative Therapy
I-hormone yokuguqula i-hormone , okanye i-HRT (isrogen kunye neprogesterone) yeempawu ze-menopausal inokunyusa umngcipheko wokufa ngumdlavuza wamaphaphu, ngakumbi kubantu ababhema. Kuhlolisiso lwabafazi abangama-16 000 abanomdlavuza ongasetyenzana wesifo samangcwaba, abo babesebenzisa i-hormone yonyango yokutshintshwa kwenyango babengama-60 ekhulwini amathuba okufa ngesifo. Kubalulekile ukuqaphela ukuba kulolu cwaningo, ukuhlanganiswa kwe-HRT kwandise umngcipheko wokufa kumdlavuza wamaphaphu ukuba sele sele unayo, kodwa kungekhona ithuba lokuba umntu abe nomdlavuza wamaphaphu.
Ngokubanzi, uphando olujongene nokuhlanganiswa njengesisombululo somhlaza wamaphaphu luxutywe, abanye bebonisa ukwanda, abanye bengabonakali nhlobo, kunye nezinye izifundo ezintsha zibonisa ukuhla kweengozi zomhlaza wamaphaphu.
Ukuphononongwa kwakhona kwe-PLoS kuboniswe indima ye-estrogen yonyango (ngaphandle kweprogesterone) yodwa emngciphekweni womhlaza wamaphaphu kwabasetyhini njengenxalenye yovavanyo lwe-Teachers California. Kule sifundo, kwakungekho nhlangano (akukho kwanda okanye ukuncipha) phakathi kokusetyenziswa kwonyango (i-estrogen kunye neprogesterone) kunye nomngcipheko womhlaza wamaphaphu. Nangona kunjalo, kubasetyhini abasebenzisa unyango lwe-estrogen kuphela, abasebenzisi base-estrogen bexesha elifutshane lokusetyenziswa (iminyaka engaphantsi kwe-5) babenomngcipheko omncinci wokufa ngumdlavuza wamaphaphu (ngamaphesenti angama-46 ubuncinane) kunye nabasebenzisi abasandul 'i-estrogen ixesha lokusetyenziswa (iminyaka engaphezu kwe-15) nayo yayinobungozi obuncinane bokufa kwesifo (ama-40 ekhulwini aphantsi kangako).
Olunye uphando lufumene umdlavuza omncinci phakathi kwabafazi ababesebenzisa iipilisi zomlomo zomlomo.
Phytoestrogens
Ukudla kwe-estrogens esekelwe kwisityalo (i-phytoestrogens), njengaleyo efunyenwe kwi-soy, iye yajongwa kwizifundo ezimbalwa ngomhlaza wemiphunga. Kwezinye zezi zinto, kubonakala ngathi abafazi abasebenzisa ukutya okuphakamileyo kwi-phytoestrogens banesifo esiphantsi somdlavuza wamaphaphu, ngakumbi phakathi kwabasetyhini abangazange bavume.
Okukwintsusa
Ekubeni umdlavuza wamaphaphu, ngeendlela ezininzi, isifo esifanelekileyo kwabasetyhini, kubalulekile ukujongana nendima enokwenzeka ye-estrogen. Kodwa njengoko kuphawuliwe ngasentla, into esiyayiqonda malunga nomhlaza wesifo se-estrogen nompompo usesezigaba zokuqala.
Naliphi na inkqubo okanye amayeza, kubaluleke kakhulu ukulinganisela iingenelelo zonyango malunga nemingcipheko enokwenzeka. Ngokomzekelo, ukuba ugqirha wakho uncoma ukuba ama-ovari akho asuswe ngesizathu esithile, inzuzo yenkqubo ingadlula kakhulu ukwanda kwenyango lomdlavuza wamaphaphu.
Okwangoku, ezi zifundo ziyisikhumbuzo esihle sokuthetha nodokotela wakho ukuba unamayeza ekutshintshiselwa i-hormone, ngakumbi xa ubhema kwaye ucela imibuzo. Ngaba kufuneka usebenzise amayeza? Ngaba zikhona ezinye iindlela? Ngaba zikhona iingenelo ezihamba ngaphaya komngcipheko ophezulu wokufa okuvela kumdlavuza wamaphaphu (okanye umdlavuza webele)?
Kwinqaku lokugqibela, ukuqonda ukuba iiseli zomhlaza zommangali zifumana i-estrogen receptors zivula iingcango zokuthi mhlawumbi ezinye iyeza zisebenzise ngokuqhelekileyo umhlaza wesifuba zingabangela indima ekhatheni umhlaza wemiphunga esikhathini esizayo.
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