Ngaba Unomdla Wokubulala Igciwane?
Ngaba ushukela wenza umhlaza? Ukuba sele unomdlavuza, ushukela ungakwenza ukhule ngokukhawuleza? Umbuzo olayishiwe, kodwa impendulo ayilula.
Zonke iiseli zakho zidinga i-glucose (ishukela yegazi) yamandla. Iiseli eziphilileyo zilandela umjikelezo wobomi bokukhula, ukwahlukana nokufa. Njengamaqabunga emthini, amaseli endala ayafa kwaye athatyathwa yinani elilinganayo lamaseli enempilo.
I-Cancer ikhula xa amaseli endala enqaba ukufa kodwa aqhubeke ekhula, ehlula kunye nokwakha endaweni enye-ukudala i- tumor .
Ngaba Ishukela Yenza I-Cancer?
Ingcamango yokuba amangqamuzana omhlaza aphumelele kwi-ushukela sele ijikeleze ubuncinane ukususela ngo-1924 kwiphepha lephepha lika-Dr. Otto Warburg, kwi-Metabolism of Tumors. IWarburg yayiyi-bielist ye-Nobel-winning biloologist-winning biosistist eyayinomdla wokubangelwa ngumhlaza xa iiseli zeengqambela zaguqula i-glucose ibe namandla ngaphandle kokusebenzisa i-oksijeni. Le nto yayinomdla wokuthakazelisa, inxalenye yokuba siyazi ukuba amaseli enempilo enza amandla ngokuguqula i-pyruvate kunye ne-oxygen. I-pyruvate ixutywe kwi-cell mitochondria. Ekubeni iiseli zomhlaza azixhasi i-pyruvate, iWarburg ibecinga ukuba umhlaza kufuneka uthathelwe ingxaki ye-mitochondrial.
Kodwa akusiyo indlela umhlaza osebenza ngayo. I-Cancer ibangelwa ukutshintshwa kwezinto eziphilayo , okanye iinguqu ezithathwa njengefa, okanye ezo zifunyenwe ngokuhamba kwesikhathi ngokudityaniswa kwama-carcinogens okanye ngenxa ye-metabolism evamile yeeseli.
Nangona iiseli ezinempilo kunye neeseli zomhlaza ziguqula ukutya kwazo kumandla ngezindlela ezahlukeneyo, loo mmahluko unempembelelo , kungekhona isizathu, somhlaza. (Funda malunga nokwahlukana phakathi kweeseli zomhlaza kunye neeseli eziqhelekileyo .)
Ushukela kunye neHyperglycemia
Nangona ukufumana ukungaphumeleli kwishukela kunye neengcambu zeengcambu zexesha elidlulileyo, kubonakala ngathi kukho ikhonkco phakathi kwamanqanaba angaphezulu kweswekile nomhlaza.
Kuyaziwa kakuhle ukuba abantu abanesifo sikashukela se-II banomngcipheko owandisiweyo wee-cancer ezininzi. Kuye kwaboniswa ukuba inqanaba lesetyhukela legazi eliphakamileyo linokubangela ukuba kusetyenziswe iiseli zomhlaza (oncogenesis), ukuchasana nokufa kweseli kumaseli omhlaza (ukuxhatshazwa kwe-apoptosis) kunye nezicubu ezinokumelana ne-chemotherapy. Ingaba oku kukukhathazeka "ngokuqhelekileyo" ushukela ophezulu wegazi, njengokuba emva kwe-dessert vs vs kuphela kulabo abane-insulin ukumelana nokuphakanyiswa kwe-sugar suars akuqinisekanga ngokupheleleyo.
I-Sugar kunye namaProtini Gcina iiCell Cancer ziphila
Kuthiwayo ukuba amangqamuzana omhlaza awunakufa-abulawa ngendlela ehlelekile njengamaseli enempilo enza. Iingcali zenzululwazi ziye zafunda le mphumo kwaye zifumanise ukuba ziphi iisilini zee-tumor zenzeni ukukhusela ukufa kwesisele. Kuphando lwebhoratri kwiYunivesithi yaseDuke, iiseli zomhlaza zibonakala zisetyenziselwa isishukela kunye neeprotheni ezithile zokuqhubeka zikhula xa zifa. Le miliza yomhlaza ibonakala isebenzisa ishukela kwizinga eliphezulu, ukwenzela ukungayithobeli imiyalelo yeselula ukufa.
Ukuphuhlisa iiDrugs ezintsha zeCrav-Coated
KwiYunivesithi yaseJohn Hopkins, iqela labaphandi libheke iindlela zokukhohlisa iiseli zesifo somhlaza ukuba zikhule ngokukhawuleza kwaye ekugqibeleni zibulale.
Bafunda i- glycosylation engavamile-njani iiseli zomhlaza zenza ishukela kunye neeprotheni ndawonye ukuze zigcine. Xa la maseli anikezelwa i- n- butyrate (ityuwa) kunye ne-carbohydrate (isisk edibeneyo), ukukhula kwabo kwancipha. Ukuze ukondle umhlaza isifo esichaphazelekayo, abaphandi bavelisa i-molecule ene-hybrid eyenziwe ngoshukela elula kunye ne-nutyrate. Ngenxa yokuba iiseli zomhlaza zithatha ishukela ngokukhawuleza, zazityhila le molekyuli entsha, ezaphazamisa ukukwazi ukuqhubeka zikhula, kwaye zafa.
Ezinye iinqununu zenzululwazi zisebenza kwiidakamizwa eziza kuxhamla ukusilela komhlaza kwishukela.
Ezinye zala machiza amatsha anganikezwa kunye ne-chemotherapy, ukwenza iisilini zee-tumor zivelele kakhulu kwiidakamizwa ze-chemo. ESwitzerland, izazinzulu zisetyenziselwa ishukela kwi "amanani ama-quantum" okanye i-nanocrystals yeziyobisi eza kuhamba esibindi kuphela, ukuphepha ezinye izitho. Yishukela kula mayeza amancinci anceda iziyobisi zijolise kwiqela elithile lomzimba, ngokunjalo ukunciphisa imiphumo emibi kunye nokwandisa ukusebenza kweziyobisi.
Ukunyanyiswa komzimba kunye neCarcer
Enye yezindlovu ekamelweni xa uthetha ngoshukela nomhlaza kukunyanya. Ukuba nezinyo ezintle kunye nokutya ukutya okuninzi ushukela kunxulumene nokukhuluphala, kwaye ukukhuluphala kunxulumene nomhlaza. Ubutyebi buguqula amanqanaba e-hormone emzimbeni odibene nomngcipheko omkhulu wokuba nomhlaza womhlaza kunye nokuba nomdlavuza okanye ukuqhubela phambili. Ngokwe-International Association of Research on Cancer, enye yezinto ezilungileyo kakhulu ongayenza kokubili ukukhusela umdlavuza kwindawo yokuqala, kwaye uthinte ukuphindaphinda xa sele ufumene unyango, kuya kuba nzima kunokwenzeka ngaphandle kokuba ungaphantsi.
Yiba nge-Smart ngeShukela kwiSidlo sakho
I-Sugar inikeza amandla kodwa ayikunikezi izondlo ezifunekayo ukunciphisa ingozi yomhlaza wakho. Iishukela zendalo zitholakala kwiziqhamo kunye neemveliso zobisi kwaye zingaba yinxalenye yokutya okunempilo. Ukongeza ushukela-uhlobo oluthile lokutya ngexesha lokucubungula, njengeshukela elimhlophe, isiraphu yengqolowa kunye ne-juice ye-juice-concentrate-kufuneka igwenywe okanye ingagcini. Ukuthengwa kakhulu kweetyukriji ezinokutya kunokukhokelela ekutyepheni kunye namaqondo aphakamileyo e-insulin, okuya kubangela ukuba umngcipheko wakho unomdla wengozi. Khawukhawule ukutya okunotyekile okufana ne-candy, iimpahla eziphekiweyo, ukutya okutya okweshukela kunye ne-sodas ukunciphisa ingozi yomhlaza wakho. Ukulinganisela ukutya kwakho kunye nokutya kwezityalo, iintlanzi kunye neengqolowa ezipheleleyo - iindawo zokutya okunempilo ezidibene nomngcipheko ophantsi womhlaza.
Ngaphantsi
Kukulungele ukutya iishukela zendalo imihla ngemihla, ingakumbi xa ziyinxalenye yokutya okunomsoco, okunjengobisi okanye iziqhamo. Ushukela ekudleni kwakho akubanga ukuba umhlaza uphuhlise. Ukuxhalabisa onke amaseli eshekile akuyi kubulala okanye ukukhusela umhlaza. Ukugcina ukulinganisela kokutya okunomsoco kunye nokuzilolonga rhoqo kunokukwenza unomzimba obunempilo kunye nezinga eliqhelekileyo le-insulin. Leyo ndlela elula yokunciphisa ingozi yomhlaza wakho.
Imithombo:
Duan, W., Shen, X., Lei, J. et al. I-Hyperglycemia, i-A Neglected Factor Ngenkqubela yeCrown. Uphando lwezoBomi kwiZizwe ngezizwe . 2014: 461917.
Kikkeri, R., Lepenies, B., Adibekian, A. et al. I-Vitro Imaging kunye ne-Vivo Liver Ukujoliswe kwii-Carbohydrates Capped Quantum Dots. Umbhalo we-American Chemical Society . 2009. 131 (6): 2110-2.
Sampathkumar, S., Jones, M., Meledeo, M et al. Ukujoliswa kweGlycosylation Inkqubo kunye neCandelo leSeli: Umsebenzi oxhomekeke kuShukela we-Butyrate-Carbohydrates Cancer Prodrugs. Chemistry kunye neBiology . 2006. 13 (12): 1265-75.