I imfundiso ye-immunological yokuguga ibonisa ukuba inkqubo yokuguga kwabantu, ngokwenene, ifom elula kunye neyonke i-phenomenon. Ngokucacileyo, i-theory ithi iqondo lokuguga, uchungechunge olunzima kakhulu lweenkqubo, lulawulwa ngokubanzi ngamajoni omzimba . Inkqubo yokuguga yinkimbinkimbi enzima kwaye ayiqondwanga ngokupheleleyo kwiindawo zonyango nezenzululwazi.
Njengoko sifunda ngakumbi kwinkqubo ngokwayo, asiyikufumanisa isizathu esibalulekileyo, apho iimbono zifana neengcinga ze-immunological yokuguga.
Isiseko se-Immunological Theory of Aging
Njengabantu abaneminyaka yobudala, sinamava amaninzi kuwo onke amashishini ethu, kuquka ukukhuselwa komzimba kunye nomsebenzi wesistim somzimba. Iingcali zonyango ziye zavakala ukuba umsebenzi wokuzikhusela umzimba uyancipha ngokwenene ubudala, obangela ukuba kubekho imicimbi eyaziwayo phakathi kwabantu abadala ekukhuleni kweengozi ezibangelwa zizifo eziqhelekileyo ezifana nokubandayo okanye umkhuhlane oza kwenzeka nakakhulu kwizifo ezingapheliyo. Ngoxa i-data ibonisa ukuba utshintsho kumsebenzi omzimba kumntu osekhulile lungabonakalisa uphawu lokuguga, abaxhasi bemfundiso ye-immunological yokuguga iguqula ubuhlobo. La ma-theorists akholelwa ukuba iimpawu zethu eziqhelekileyo zokuguga ezifana nezifo ezingapheliyo zibangelwa yiinguqu kwi-immune system.
Inkqubo yokuFunjwa kweMpilo
Kuyaziwa ukuba ukuguqulwa kwamasosha omzimba okubonakala ngathi kuhamba kunye nokuguga kunokuba nefuthe ngqo kwixesha elide lomntu. I-immune system ibalulekile ekugcineni imizimba yethu iphilile. Akusikhuseli nje kuphela kwiintsholongwane kunye neebhaktheriya, kuya kunceda ukuchonga nokususa iiseli zomhlaza kunye neesxinisi.
Njengoko sikhula, ubunako balezi zinto bangela umonakalo emzimbeni wethu ukwanda.
Kodwa into engaziwayo yinto ebangela ukuba utshintsho lomsebenzi wesistim somzimba kunye nendlela abaphuhlisa ngayo kunye nenkqubela phambili. Kukho idatha yoluntu oluqinileyo ebonisa ukuba isistim somzimba sokuguga-mzimba esikudala, okungenani inxalenye, kubangele kunye / okanye ichaze ezinye iinkalo zeenkcukacha ezikhulayo zeenkqubo zokuguga.
Indlela Ukuguquka Kwendlela Yokuzikhusela Ngomzimba Kungabangela Njani Ubume
Ngaphandle kokunyamekela kwiintsholongwane eziqhelekileyo kunye neentsholongwane ze-bhakteria, ukuguqulwa kwamathambo omzimba kunempembelelo enkulu.
Siyazi ukuba njengoko sineminyaka ubudala, iinombolo zamaseli ezibucayi kwisistim somzimba zamasosha omzimba ziyancipha kwaye zisebenza ngaphantsi. Siyazi nokuba ukuqala ngaphambi kweminyaka engama-20, i-thymus (eyona ndawo yengqondo ejongene nokuvelisa iiseli ezithile zamagciwane) iqala ukuhlahlela. Kodwa xa kuziwa kwimfundiso ye-immunological yokuguga, abanye abantu kwiindawo zenzululwazi yezokwelapha bajolise ekunyuseni ukudibanisa kwe-immunogenetic yamaseli esintu njengononophelo. Iingcamango zibonisa ukuba ukunyuka kwamanzi okanye ukuguqulwa kwamaseli ekuguga kungagqibeleni kukukhokelela ekuhlulekeni kokuqatshelwa kweseli kunye nokuphazamiseka kweenkqubo ezithile zomzimba, ekugqibeleni kudala ukuphendula okuzenzekelayo njenge- inflammation engapheliyo.
Namhlanje, ukuvuvukala okungapheliyo kukholwa ukuba kugaleleke kuzo zonke izifo ezingapheliyo nezigulane ezisuka kumdlavuza ukuya kwi- Alzheimer's .
Inzululwazi yokuguga
Imfundiso ye-immunological yokuguga yinto enye eyayizama ukucacisa isizathu sokuba sineminyaka yobudala. Ngona kunjalo ngokuqinisekileyo, ijongene neenkqubo ezinzima kakhulu kunye neenkqubo (ukuguga nokuzikhusela) esingaziqondi ngokupheleleyo.
Imithombo:
Ukuguga Ngaphantsi kweMicroscope; Iziko zeSizwe zezeMpilo, iZiko leSizwe lokuguga.
Franceschi, C., noJ. Campisi. Ukuvuvukala okungapheliyo (Ukuvuvukala) kunye neNdawo yokuHlaba kwiNtsholongwane. IiNdaba zoLwazi lwe-Gerontology A: IiSayensi zoBomi kunye neSayensi yezoNyango 69. iSuppl 1 (2014).
Fulop, T., JM Witkowski, G. Pawelec, C. Alan, no-A. Larbi. "Kwi-Immunological Theory of Age." Izihloko eziManyeneyo kwiGerontology 39 (2014): 163-76.
UWalford, uRoy L. "I-Immunologic Theory of Aging." I-Gerontologist 4.4 (1964): 195-97.