Uninzi lweziganeko zomhlaza wesibeleko zixhaswa ngamahomoni e-estrogen kunye neprogesterone. I-hormone yokwelapha, ebizwa ngokuba yi-endocrine yonyango, isetyenziselwa ukususa okanye ukuvimba ii-hormone kunye nokuyeka okanye ukunciphisa ukukhula kweeseli zomhlaza. Ukuba umhlaza wakho unobungozi be-hormone, i-hormone therapy ingaba yinxalenye yesicwangciso sakho sonyango.
Ukuba ugqirha wakho uchaza le ngxaki yomhlaza wesifuba sakho sokuqala, cwangcisa ukuthatha unyango lwe-hormonal iminyaka emihlanu emva kokuzalisa unyango lwakho oluphambili.
Inzuzo enkulu yale hlobo lonyango kukukhusela i-estrogen ekuveliseni amangqamuzana omhlaza wesi -estrogen , ngaloo ndlela unciphisa umngcipheko wokuphindaphinda. Umhlaza wesifuba ongenayo i-estrogen-receptor, i-hormonal therapy ayisebenzi.
Amachiza okanye Utyando
IiHormones ziyancitshiswa ngamachiza kunye / okanye ngokuhlinzwa. Kwimisetyhini yangaphambi kwe-menopausal, ii-ovari zidala uninzi lwe-estrogen kwaye, emva kokuba unyango oluphambili, ukuthatha i- Tamoxifen kuya kukwanela ukuvimba i-estrogen kumaseli omhlaza.
Ukuba kuyimfuneko, kubafazi abancinci abanomdlavuza webele we-estrogen, i-ovaries ingavalwa okwethutyana kunye neeyunithi zokuxhatshazwa. Kubafazi abasemngciphekweni, ii-ovari ziyakususwa ngokugqithiseleyo (oophorectomy). I-Oophorectomy yinyathelo elibalulekileyo lokuthatha njengoko ungasayi kuvelisa . Xoxa ngale ngxaki nogqirha wakho ngaphambi kokuba uqale unyango.
Anti-Estrogen Hormone Iziyobisi
Iiklasi ezimbini zezilwanyana zisetyenziselwa unyango lwe-hormone kwaye ezi zinikwe ngokusekelwe kwimeko yakho ye-menopausal kunye nokuxilongwa komhlaza wakho webele: I-Selective Estrogen Receptor Modulators (i-SERMs) kunye ne-Aromatase Inhibitors (AI).
Iziphumo eziPhakathi
Ukuba ama-ovari akho avaliwe okanye ususwe okanye uthathe unyango lwe-hormone ungabangela ukunyuka komzimba . Awukwazi ukufumana zonke iimpawu zokuqeda umzi, kodwa zilapha ezinye zeziphumo eziqhelekileyo ezichaphazelekayo ezivela kulolu hlobo lwonyango:
- Ukutshisa okushisayo
- Ukukhupha ebusuku
- Ukuhamba kweemvakalelo
- Ukuma komzimba
- Ukukhathala
Ukusetyenziswa kweMigqaliselo
Iingonyango zeHormonal zisetyenziselwa emva kokuhlinzwa kunye nezinye izibonelelo zonyango lomhlaza wesisu. Ezi zinceda ukukhusela ukuphindaphinda okanye ukunyuka kwesifo kwi-estrogen-receptor enomdlavuza webele, ukumisa i-estrogen ekukhuthazeni ukukhula kwamaseli omhlaza wesi-esrogen.
Ukuba ugqirha wakho uchaza izidakamizwa zokulwa ne-estrogen, kubalulekile ukuba uthabathe rhoqo kunye nangona nje ukuba ufuna.
| Isifo somhlaza wesifuba sokuqala | ||
| Menopausal Isimo | Anti-Estrogen | Ubude bexesha |
| Ngaphambi | Tamoxifen | 2 - 5 iminyaka * |
| Ngaphambi | Ukudibanisa izidakamizwa zokudambisa i-ovari, ii-SERM kunye nee-AI | Iminyaka emi-5 (izilingo zamachiza) |
| Post- | Aromatase Inhibitor | 5 iminyaka. Ukuqhubela phambili okongezelelweyo 5 kunokuphucula ukusinda okungenazo izifo. |
| * I- Tamoxifen inokunikezelwa iminyaka emibini kwaye ilandelwe ngu-Aromasin iminyaka emithathu, kwezinye iimeko. Kubafazi abaphathwa nge-tamoxifen iminyaka emihlanu, okanye ukuqhubela phambili i-tamoxifen okanye ukutshintsha kwi-AI kwiminyaka emihlanu eyongezelelweyo kuyasebenza ekunciphiseni ubungozi bokuphindaphinda kwaye kukho idatha ebonisa ukuphuculwa kokusinda ngokubanzi, nayo. | ||
| Izifo zeMetastatic | ||
| Menopausal Isimo | Anti-Estrogen | Ubude bexesha |
| Naluphina | Tamoxifen | Kuze kubekho ukusebenza |
| Naluphina | I-estrogens ephakathi kunye nephezulu | Kuze kubekho ukusebenza |
| Naluphina | Aromatase Inhibitors | Kuze kubekho ukusebenza |
| Post- | Injection yeFaslodex | Kuba izifo aziphendulanga kuTamoxifen okanye kuFareston |
| Naluphina | Megace | Kuba izifo aziphendulanga kwezinye iirmathrapies |
| Naluphina | Androgens (amahomoni angamadoda) | Isetyenziswe emva kokuba zonke ezinye izifo zonyango zingasebenzi |
| Ngaphambi | Ukudibanisa izidakamizwa zokudambisa i-ovari, ii-SERM kunye nee-AI | Kuze kubekho ukusebenza |
Qaphela ukuba ngokuqhelekileyo, kwizigulane ezinobungozi obuphezulu be-tumors (i-egnode isifo esihle okanye i-T3 okanye i-tumors ephezulu), ukwenzela ukunciphisa umngcipheko wokuphindaphinda, ubude bonyango lwe-hormone kufuneka bongezelelwe kwiminyaka elishumi.
> Umthombo:
> INational Cancer Institute. IHormone unyango lweCanscer Breast.