I-Neulasta (pegfilgrastim) yipilisi ngamanye amaxesha asetyenziswa ngexesha le-chemotherapy yomhlaza wesifuba ukwenzela ukwandisa amanani e-white white counts ukwenzela ukunciphisa umngcipheko wesifo. Yintoni oyifunayo ukuba uyazi malunga nale nkunkuma, kubandakanywa nemiphumo emibi?
I-Neulasta (Pegfilgrastim) Ingqwalasela
I-Neulasta (i-pegfilgrastim) isilwanyana esinikwe abantu abaye okanye kulindeleke ukuba bavelise i- neutrophiy -induced neutropenia (inani elincinane le- neutrophil , uhlobo olulodwa lweselungu legazi elimhlophe) ngexesha le-chemotherapy yomhlaza webele.
I-Neulasta yinguqu ye-granulocytes-stimulating factor (G-CSF), isakhi eshukumisa ukuveliswa kweeseli ezimhlophe zegazi emnzini wethambo. Yisilwanyana esicacileyo esivame ukunikezwa njengesibhozo apho inaliti ifakwe phantsi kwesikhumba.
I-Neulasta isilwanyana esisebenza ixesha elide esidla ngokufuneka kuphela kanye emva kokunyuka kwe-chemotherapy, ngokuchasene ne- Neupogen (filgrastim), enikwa imihla ngemihla iintsuku eziliqela nge-injection.
Sebenzisa iCataltic Breast
I-Chemotherapy yomhlaza wesifuba ichaphazela zonke iiseli ezihlukanisa ngokukhawuleza emzimbeni wakho, kubandakanywa neeseli zomnatha weethambo, ezivelisa iiseli ezimhlophe zegazi, iiseli ezibomvu zegazi kunye neeplatelet. Ukunciphisa umongo wamathambo ngexesha le-chemotherapy kunokubangela ukuba i-anemia (i-red red count count), i-neutropenia (inani elincinane le-neutrophil) kunye ne-thrombocytopenia (inani elisezantsi leplatelet).
Inani eliphantsi le-neutrophil (ngamanye amaxesha libizwa nje ngokuba li-white white cell count count) lingaba lukhulu kuba luyakwazi ukuthatha abantu abafumana i-chemotherapy kwizifo.
Injongo yokusebenzisa i-Neulasta kukukunceda ukukhusela ezi zifo.
I-Neulasta isebenza njani
Ngokuqhelekileyo, umzimba wakho uvelisa iprotheni ekhuthaza ukuveliswa kwe-neutrophils. Ngexesha le-chemotherapy, ukuveliswa komzimba wakho we-neutrophils kuphazamisekile, i-Neulasta isebenza ekuvuseleleni ukuveliswa kwe-neutrophils, kwaye ikhule kwaye ivuselele i-neutrophils esele ikhona.
Indlela iNeulasta inikwe ngayo
Uya kufumana umjovo weNeulasta malunga neeyure ezingama-24 emva kokunyuka kwe-chemotherapy yakho. Akunakunikwa ngokukhawuleza kuba kungenakusebenza kancinci. Ngokungafani neNeupogen, ekufuneka yenziwe ngokuphindaphindiweyo kude kube yilapho i-neutrophil yakho ibalwa, i-Neulasta inikezelwa kanye kuphela kwimijikelezo ye-chemotherapy ye-2 okanye ye-3. Unokwenza le ngxube kwisandla sakho esiphezulu, isisu, intamo, okanye iintsimbi.
Abanye abane-oncologists banezigulana zizinikela ngokwaso ngokwasemzimbeni emva kwe-chemotherapy, kwaye i-"injection body" inokuzenzekelayo nayo iyafumaneka. Ezinye i-oncologists zincoma ukuba unayo injini kwikliniki yakho okanye ngogqirha wakho wokunakekelwa ngokusisigxina xa kwenzeka ukuphazamiseka kwesifo kwiyeza.
Eminye i-Neulasta
Njengoko kuphawuliwe ngaphambili, enye indlela eya kwiNeulasta (pegfilgristim) yiNeuopogen (filgristim). Ngamanye amaxesha i-oncologist iyakubuza ukuba yiyiphi imithi oyithandayo. Nangona iziyobisi zisebenza ngendlela efanayo, kukho ukungafani phakathi kwe-Neulasta ne-Neupogen , kuquka ukuphindaphinda kwama-injections, ukunyamezela, kunye neendleko.
Ezinye iziphumo eziqhelekileyo
Enye yeziphumo ezibi kakhulu ezivela kwi-Neulasta yindlela yokuphikisa, kwaye kwakhona, kwesi sizathu sokuba ezinye i-oncologists zikhetha ukuba udutshulwa lwenziwe kwiklinikhi.
Ukuba uzinika izibhengezo zakho ekhaya, kufuneka uqhelane neempawu zendlela yokuphikisa okanye i-anaphylaxis.
Umkhuhlane usenokuvela, kwaye kubalulekile ukuba ugqirha wakho aqinisekise ukuba umkhuhlane wakho ungenxa yokujola kwakho, okanye kunoko usulelo oluhambelana nomlinganiselo wakho we-white blood cell.
Phantse umntu wesithathu wabanikezeli be-Neulasta bachaza uhlobo oluthile lwesifo seethambo. Izifundo zangaphambili zafumanisa ukuba i-Naprosyn / Aleve (naproxen) yanciphisa intlungu yesifo kunye nokuphazamiseka kokulala (mhlawumbi ngenxa yentlungu). Kungekudala kwafunyaniswa ukuba i-antihistamine Claritin (loratidine) yomibini yanciphisa umngcipheko wemiphumo emibi kwaye yabangela abantu abancinci ukuyeka imichiza kunabo baphathwa nge-Aleve / Naprosyn (naproxen).
Ukuba uyaphawula intlungu yethambo, uthetha ugqirha wakho malunga naluphi unyango olucebisa ukuba ulisebenzise. Ukuhlamba kwindawo yokuhlambela ngokufudumele kunokukunceda neentlungu zethambo e-Neulasta.
Biza ugqirha wakho ukuba Unayo Ezi zibonakaliso
Iziphumo eziqhelekileyo ezichaphazelekayo kunye nokuphendula okungathandekiyo kunokwenzeka, kwaye kubalulekile ukubiza umnqweno we-oncologist ukuba unayo nayiphi na impawu echaphazelekayo. Oku kubaluleke ngakumbi ukuba uyaphawula:
- Ukukhathala okungavamile kunye nokunyaniseka
- Iintlungu zesifuba
- Iintliziyo zentlungu
Iimpawu eziKhuselekileyo ziquka
Umele ugqirha ugqirha wakho ngokukhawuleza, kodwa khangela uncedo lwezokwelapha ngokukhawuleza (fowuni 911) ukuba uyaphawula nayiphi na impawu ebonisa indlela yokuphendula nge-anaphylactic
- Iimbuzi
- Ukuphefumula okunzima
- Ukuvuvukala ubuso bakho, imilomo, ulwimi, okanye umqala
- Ukukhawuleza kwandiswa phezu komzimba wakho
- Intlungu yesisu, ingakumbi intlungu kwisisu sakho sekhohlo phezulu
- Iintlungu zentlungu
Izingozi ezinokwenzeka zokusebenzisa i-Neulasta
I-Neulasta isilwanyana esinokukhuseleka esetyenzisiweyo kwiintlobo ezininzi ze-neutropenia, kwaye isininzi sithuba, iimiphumo ezibi okanye umngcipheko weyeza kunyusa umngcipheko wokubala kwe-neutrophil ephantsi. Izimpembelelo ezingalunganga (kodwa ngamanye amaxesha zenzeka) ziquka:
- Impendulo eyingozi kakhulu.
- Umntu omdala ophefumulayo wesifo (ARDS) .
- Inkathazo yeselintshi yeSickle kubantu abane-anemia yesalente yesigulo.
- Ukuphuka kweSplenic .
- Ubunokwenzeka bokukhuthaza ukukhula kwesisu (le nto inokwenzeka kwaye ayizange iboniswe, njengoko i-Neulasta yinto yokukhula)
Ngubani omele aphephe le Michiza
Ungathathi le nkunkuma ukuba:
- Ukhulelwe okanye uncelisa
- Uhlaselwa kwi-Neulasta
- Uyaziqhelanisa nemveliso eyenziwe usebenzisa i-bacterium E. coli
Iingcebiso Ngethuba loNyango
Ngaphambi kwejoyi yokuqala yokuqala ye-Neulasta, ugqirha wakho uya kuyala iCBC rhoqo (ukuzaliswa kwegazi epheleleyo) ukujonga amanqanaba eeplatelet zakho kunye neeseli ezimhlophe negazi ezimhlophe, ngokuqwalasela okhethekileyo kwinani elipheleleyo le-neutrophils egazini lakho. Njengoko unyango luqhubeka, uya kuba nokuhlolwa kwegazi ngaphezulu ukujonga ukusebenza kwe-Neulasta.
Ukuba unonyameko okanye ukhulelwe, xubusha oku ngogqirha wakho ngaphambi kokuthatha i-Neulasta. Akukho zifundo ezaneleyo ezenzelwe ukucacisa umphumo walesi sidakamizwa ngobisi lwebele okanye kumntwana wesisu.
Ukunciphisa Umngcipheko Wakho Wezifo ngexesha leKhemotherapy
Nangona ufumana iinjenge ze-Neulasta ukuphakamisa isibalo sakho segazi elimhlophe, usenokuba usengozini yokuhlawula isifo ngexesha le-chemotherapy. Ngamanye amaxesha iiseli zegazi ezimhlophe, nokuba zikhona ngokwaneleyo, azisebenzi kakuhle. Kwaye nangokusebenzisa i-Neulasta, unakho amaxesha emva kokunyakanyiswa kwakho xa inani lakho lamhlophe legazi liwela ngaphantsi kwamanqanaba apho ukutheleleka kunokwenzeka khona. Thatha umzuzwana ukuba ufunde malunga nokwenza ntoni ukunciphisa umngcipheko wentsholongwane ngexesha le-chemotherapy . Iqhinga: ezinye zeemilinganiselo aziyazi kakuhle kwaye zinokumangalisa.
> Imithombo:
> Aapro, M., Boccia, R., Leonard, R. et al. Ukucwangcisa indima yePegfilgrasti (i-G-CSF ehlala ixesha elide) yoKhuselo lweKhemotherapy-eyenziwa yi-Febrile Neutropenia: Iziphakamiso zoKhenketho. Unonophelo loNcedo kwiCancer . 2017. 25 (11): 3295-3304.
> Botteri, E., Krendyukov, A., kunye noG. Curigliano. Ukuthelekisa i-Granulocyte Colony-Fact stimulating Factor Filgrastim kunye nePegfilgrastim kwii-Biosimilars kwiMigangatho yoPhuculo noKhuselekileyo: Uhlalutyo lwe-Meta-Analysis of Trials of Clinical Trials in Breast Cancer Patients. I-European Journal yeCarcer . 2018. 89: 49-55.
> Kirshner, J., McDonald, M., Kruter, F. et al. I-NOLAN: I-Randomised, IsiGaba sesiFundo sesi-2 ukulinganisa umphumo weProphylactic Naproxen okanye i-Loratidine no-No Prophylactic Treatment kwi-Bone Pain kwizigulane ezineCatrice-Stage Breast Stage Ukufumana i-Chemotherapy ne-Pegfilgrastim. Unonophelo loNcedo kwiCancer . 2018. 26 (4): 1323-1334.