Ekuqaleni kwee-1940, izazinzulu ziye zaphawula ukuba abantu ababenomdla wokukhanya kwelanga babenamazinga aphakamileyo yomhlaza wesikhumba, kodwa amazinga athile eemhlaza. Kule minyaka, uphando lufumene ukuhluka kweendawo kwiiyure ezingama-24 ezihlukeneyo zomhlaza, kunye namazinga aphantsi angamachiza kwiindawo ezinokukhanya kwelanga.
Namhlanje, kucacile ukuba i- vitamin D ixhomekeke kakhulu kule mihluko, kwaye sinobungqina obuqinileyo bokuthi ukugcina amanqanaba e-vitamin D aneleyo kunceda ukukhusela umdlalo weengcambu zeengcingo ezininzi ezibandakanya, kunye nesifo se-cardiovascular, izimo ezizimeleyo kunye ne-osteoporosis.
Ikhonkco phakathi kweVitamin D kunye neCanscer Breast
Phakathi kwabasetyhini abaneengculaza zesifuba , malunga neepesenti ezingama-75 abanalo i-vitamin D. Abasetyhini abanamanqanaba egazini e-vitamin D abanamathuba amaninzi okufumanisa ukuba banomdlavuza webele, kwaye abo banesifo somhlaza wesibeleko abanako ukufumana ukuphindaphinda kwesi sifo ukuba amazinga abo e-vitamin D anele. Ngo-2014, ukuhlaziywa kwemeta yezilingo ezingama-56 kwagqitywa ukuba ugalelo lwe-vitamin D3 ludibene nokuncipha kwepesenti ezili-12 kwengozi yokufa kunoma yimuphi umhlaza.
I-Vitamin D ingaba nefuthe ngokukhethekileyo ekukhuseleni umdlavuza webele. Oku kwenzeka ukuba kuqhutywe xa uphando lwabafazi abangaphezu kwama-57,000 be-postmenopausal bafumanisa ukuba abafazi abathatha isistim e-vitamin D banokuncitshiswa kweepesenti ezingama-26 engozini yomhlaza wesisu. Yintoni eyabangela ukuba oku kutholakala ngokukhethekileyo kukuba kwenzeka ngokukodwa kubasetyhini abaye basebenzisa i- hormone yonyango yokutshintshwa .
Ukusetyenziswa kwe-hormone yonyango yokutshintshwa kwamathambo kuma-postmenopausal bafazi behlile ngokukhawuleza emva ko-2002, xa isifundo esikhulu, esibizwa ngokuba yiNkulumbuso yezeMpilo yabasetyhini, sagqitywa kwangethuba ngenxa yokwanda kwengozi yesifo senhliziyo, isifo soxinzelelo kunye nomhlaza wesibeleko kwiqela elifumana unyango lwe-hormone.
I-Estrogen iyaziwa ngokukhuthaza ukukhula kunye nokwanda kweeseli zomhlaza zesisu.
Ukugqithisa okuphezulu kwe-estrogen, ngenxa yezinto ezinjengokuqala kokuya esikhathini kunye nokunyuka kwamafutha omzimba , kudibene nomngcipheko omkhulu wesifo somhlaza. I-vitamin D isongezelelo iyakwazi ukuchasana nemiphumo yokukhuthaza umdlavuza ye-hormone.
Ezinye izinto zokutya ezichasene nezenzo okanye ukuveliswa kwe-estrogens zidibene nomngcipheko omncinci womhlaza wesisu. Imizekelo embalwa: ama-mushroom aqukethe i-aromatase inhibitors (i-aromatase iyin enzyme eyenza i-estrogen); ii-soybe kunye neeflekisi kunye nembewu ye-chia ziqulethe i-phytoestrogens eneempembelelo zokulwa ne-estrogenic; ukutya okuphezulu-fiber kuququzelela ukuphuma kwe-estrogen. I-Vitamin D ibonakala inemiphumo efanayo.
Ngokwezifundo ze-in vitro kumaseli omhlaza wesifuba, uhlobo olusebenzayo lwe-vitamin D lugxininisa i-aromatase expression, ephumela ekuvelweni kwe-estrogen ephantsi. I-Vitamin D nayo iboniswe ukunciphisa inani le-recerosi ye-estrogen kwiiselintshi zengqengqele ezikhuselweyo, okwenza iiseli zingaphenduli kangako kwiimpawu zokukhuthaza umdlavuza.
Ngaba i-Sunshine ilanga?
I-Vitamin D yokwenziwa kwesikhumba iyahluka phakathi kwabantu. Ayikho ixesha elithile lokutshatyalaliswa kwelanga eliza kusebenza kuwo wonke umntu, kwaye abaninzi bethu, inani elifanelekileyo lokukhanya kwelanga alinakwanela.
Kuhlolisiso lwabahlali baseHawaii abanokukhanya kwelanga-ukulinganisa iiyure ezingama-29 ngeveki-malunga neepesenti ezingama-50 bebanamazinga e-vitamin D engaphantsi kwama-30 ng / ml. Ngaphezu koko, abanye bethu bahlala kwiindawo eziphezulu ezenza uVithamini D ngokwaneleyo kunzima.
Indlela efanelekileyo yokukwazi ngokuqinisekileyo kukuba uvavanyo lwegazi lwe-25 (OH) D. Sincoma ukusebenzisa izongezelelo ukuze sifinyelele kwindawo enhle ye-30-45 ng / ml. Kwabantu abaninzi, i-dose yemihla ngemihla yokuxhaswa kwe-vitamin D3 (malunga ne-1000-2000 IU / imini) ifanelekile ukufikelela kule window ye-30-45 ng / ml.
> Imithombo:
> Isibonelelo seWB. Ucwaningo lwezinto eziphilayo ze-UVB-vitamin D-cancer hypothesis. I-Anticancer Res 2012, 32: 223-236.
> Krishnan AV, Swami S, Feldman D. Iingeniso zokwelapha ezinokwenziwa kwe-vitamin D ekwonyango lwe-estrogen receptor. Steroids 2012, 77: 1107-1112.
> Cadeau C, Fournier A, Mesrine S, et al. Ukusebenzisana phakathi kwe-vitamin D yokuxhaswa kunye ne-menopausal i-hormone yokwelapha ukusebenzisa ingozi yomhlaza wesifuba: ubungqina obuvela kwiqela elingu-E3N. Am J Clin Nutrition 2015, 102: 966-973.
> Binkley N, uNototny R, uKrueger D, et al. Isimo se-vitamin D esincinci naphezu kokukhanya kwelanga. J Clin Endocrinol Metab 2007, 92: 2130-2135.
> IBischoff-Ferrari HA. I-serum efanelekileyo ye-25-hydroxyvitamin D yamanqanaba empilo yeziphumo ezininzi. Adv Exp Med Biol 2008, 624: 55-71.