Iimpembelelo zeVithamini C Ngamana zixhomekeke kwiZityholo
Xa ucinga ngoxinzelelo, mhlawumbi ingqondo yakho iphendukela kwiishedyuli, ixesha lokugqibela, iimvavanyo, ubudlelwane, okanye neminye imingeni umntu anokujamelana nayo ebomini. Ihlabathi namhlanje alinakho ukusweleka kwezinto ezinokubangela uxinzelelo.
Nangona kunjalo, akuyena wonke umntu ophendula ngendlela efanayo nalezi zinto ezikhuselekileyo. Imithombo yokuhlukahluka komntu ngamnye ininzi, inxenye ngenxa yokuba sikwazi ukujamelana nokuphendula ngokufanelekileyo kwimimandla yethu.
Kukho ukulingana kwamaselula kunye noxinzelelo, ngokunjalo. Njengokuba singayifumana indawo esicinezelekileyo ngezinye izihlandlo, iimeko zeseli zinokuba nezintlobo ezahlukeneyo zokubangela ukucindezeleka-umzekelo, i-molecule ekhwaxayo kumanzi ojikelezayo, okanye ukungakwazi ukucwangcisa ngokufanelekileyo iamolekyuli zamaselula zangaphakathi.
Xa ucinga ngamaseli omhlaza, ngokukodwa, awukwazi ukudibanisa ngokukhawuleza kunye nobunzima bokubandezeleka. Iiseli zomhlaza zisoloko zichazwa ngokwemiqathango enjengokuthi 'ayinakunqandwa' kunye 'nokungafi' kuba zibonakala zivelisa kwaye zisasazeka ngaphandle kwemida. Noko ke, kuvela ukuba iiseli zomhlaza zisebenza phantsi koxinzelelo olukhulu ngokukodwa, uxinzelelo lwe-oxidative. Futhi i-vitamin C ingadlala indima ebalulekileyo xa ifika kuma-enzyme athile anceda iiseli ziphendule ukuxinezeleka.
Yintoni ukuxinezeleka koxinzelelo?
Uxinzelelo lwe-oxidative , ngokucacileyo, ukungalingani kwimeko yeselula.
Njengoko le ngcamango iqhutywe phambili, ukungalingani kunokubhekwa njengemfazwe engalingani phakathi kwemveliso yenzalo eyingozi (i-radicals ekhululekile) kunye nokukwazi komzimba ukulwa nemiphumo ebungozi yile ntshaba (nge-antioxidants).
Usenokuba ufunde nge- radicals yamahhala kwi-chemistry: ngokusemthethweni, bachazwa njengama-molecule angatshitshiyo asebenzayo ngokukhawuleza kwaye aphilileyo, kunye nee-electron ezingenamsebenzi.
Ngokomzekelo, i-molecule ye-oksijini emzimbeni ngamanye amaxesha ahlukaniswe ngama-athomu athile e-oksijeni, nganye i-electron engenamsebenzi.
Ii-electron zifuna ukuba zibini, ngoko ke ii-athomu ezingalingani, ngoku zibizwa ngokuba yi-radicals yamahhala, khangela ezinye iifoni eziyingxenye yomzimba, phantse njengezilwanyana, ukuba zidibene ne-electron enye enye i-molecule emzimbeni. Olu luxinzelelo lwe-oxidative, ngoko ke lubangela ukulimala kwiiseli, iimbumba, iiprotheni kunye ne-DNA.
Ngoko, kutheni amangqamuzana omhlaza asebenza phantsi kweqondo eliphezulu lokuxinzezeleka kwengcinezelo? Ewe, ngokuqhelekileyo la maseli anamazinga aphakamileyo e-radicals ekhululekile kumgangatho wesiseko, ukuqala, ngaphambi kokuba abe nomhlaza. Emva koko, njengoko iseli ithatha amanqanaba amaninzi ukuya ekubeni ngumhlaza, izinto zihlala ziguquka ngokwemigaqo yokuba loo cell isebenza ngayo imetabolism, enokubangela ukuba kubekho amazinga angaphezulu kwama-radicals.
Ngokuqhelekileyo, kukho umlinganiselo phakathi kokuveliswa kwemveliso kunye nokupheliswa. Kukho amaqela "ahlukeneyo" ahlukeneyo, elinye iqela elivelisa i-radicals ekhululekile njenge-superoxide anion (i-O2-), i-hydrogen peroxide (H2O2), i-hydroxyl radicals (OH-), njl, kunye nezinye iikomiti ezinika iindlela zokuzivikela ezinamandla (antioxide dismutase ( SOD), i-catalase (CAT), glutathione peroxidase (GPx), njl.
Xa utshaba olukhululekile olungabonakaliyo kwaye / okanye lupheliswe, umphumo unokuthi ube ngumonakalo weli cell, ukulahleka komsebenzi kunye nentembeko yefom membrane, kunye nomonakalo we-DNA, ukukhuthaza utshintsho olusenokubangelwa yendalo kunye nokukhula kweeseli ezingalawulwayo. Esi siphumo sokugqibela sikwazi ukungazinzi ngokomzimba, kwaye sinokufaka umbane emlilweni ngokubhekiselele kuhambo olubi lweseli.
Ukukhululeka kwama-radicals kunye nokuxinwa kwe-oxidative kudibaniswa nenani labantu izifo ngaphandle komhlaza, kuquka isifo senhliziyo, isifo se-Alzheimer, isifo sika-Parkinson, kunye nokunye. Kukho ukudibanisa nokuguga, ngokuqokelela ngokukhawuleza komonakalo omkhulu.
Izimo ezenza i-radicals yamahhala zifumaneke kwindawo yethu, kubandakanywa ukutya esikudlayo, kodwa nazo zenzeka emizimbeni yethu njengemveliso yendalo yemetabolism.
Njani Izinto ezinokuthi zifana neVithamini C Ukukhusela I-Cancer?
I-Vitamin C iye yazama kwiinkalo ezahlukeneyo zonyango kunye nokukhuselwa komhlaza; Nangona kunjalo, iziphumo asisoloko zipenda umfanekiso ocacileyo. Impendulo yombuzo wendima ye vithamini C ekukhuselweni komhlaza kunye nokunyanga kunokuxhomekeka kwisicatshulwa esithile-kunye ne dose ye-vitamin C, phakathi kwezinye izinto.
Kwiindawo eziphantsi, i-vitamin C inendima ye-antioxidant, ikhusela i-oxidation. Ukutya kwe-antioxidant, i-ascorbic acid (i-vitamin C), i-carotenoids (i-vitamin A) kunye ne-tocopherol (i-vitamin E), i-selenium, kunye ne-flavonoids, iyanconywa ngenxa yezenzo ezichasayo zokukhutshwa kwe-oxidation kunye nokuveliswa kwemveliso.
Nangona kunjalo, amazinga aphezulu e-vitamin C anokunyusa ukuveliswa kwe-ATP (eyenziwe yi-mitochondria) ekunciphiseni ukufa kweseli yesistim kwiimvavanyo zeesilini ze-tumor, ngokusebenzisa indlela yokuxhamla.
Izifundo zibonisa umsebenzi olwa nomdlavuza oxhomekeke kumdlavuza ochaphazela iinkqubo ezahlukeneyo zeselula ezibandakanya ukufa kweeseli ezicwangcisiweyo, umjikelo wokukhula kwamaseli, kunye nokutyunjwa kweeselfowuni, ukwanda komhlaza wesifo kwiebhabhi zokuvavanya eziphatha iiseli zomhlaza kunye ne-mitoxantrone (i-chemotherapy drug) kunye ne-vitamin C .
Ngaba Kuya kuba Nendima Yezinga eliphezulu kwi-Vitamin C kwi-Leukemia?
Kulolu hlobo, ezinye izifundo zicebise umsebenzi ngokubhekiselele kwiindidi ezahlukeneyo zomshukela, kodwa ezinye iingcaphephe zithi i-vitamin C ingenza i-chemotherapy ingasebenzi kakuhle.
Impendulo emfutshane kumbuzo ongentla apha "mhlawumbi," kwaye kwakhona, "inokuxhomekeka kwi-leukemia." Kungaba kubalulekile ukujonga i-vitamin C kwiindawo ezininzi ezahlukeneyo ngaphambi kokuba wenze izigqibo malunga nokusetyenziswa kwayo kunomdla othile, kodwa ezinye Iziphumo zokuqala ezivela kwizifundo ze-laboratories ze-hematologic malignancies zikhuthaza.
Ucwaningo lwe-2017 malunga nefuthe le-vitamin C kwiiseli ze- leukemia lishicilelwe kwincwadi ethi "iSeli." Kwingqungquthela yabo, abalobi baqaphele ukuba ubungqina be-vitamin C njengonyango olufanelekileyo lomhlaza luye lwaqhubeka luphikisana ngoku.
I-Vitamin C Ngamanye ama-Enzyme ebalulekileyo kwi-Leukemia
Ngokukodwa, eli qela labaphandi lihlolisise utshintsho lwezityalo kwi-enzyme ebizwa ngokuba yiTet (i-Ten Eleven Translocation) i-methylcytosine dioxygenase 2, okanye i-TET2. Bafumana ukusebenzisana okuthakazelisayo kunye ne-vitamin C kunye nokusebenzisana kwe-enzyme okwakubonakala kuphucula ukuphumelela kwezilwanyana ezithile zonyango. Le nto yayisifundo sezilwanyana, ngoko ke iziphumo kubantu azikaziwa, kodwa iziphumo zazingcangcazela.
Emzimbeni, iiseli ezintsha zegazi zivela kwiiseli ezikhethekileyo emnzini wethambo obizwa ngama-hematopoietic stem cells . Izifundo eziphambili zibonise ukuba i-enzyme ye-TET2 inokwenza ukuba la maseli akhulayo akhule abe ngamaseli egazi, aqolileyo, aqhelekileyo-amaseli aphelisa ukufa ngokufanayo nakweyiphi iseli eqhelekileyo. Ngokwahlukileyo, kwi-leukemia, amangqamuzana angamaqabane awaqokanga kakuhle, kodwa kunokuba aphinde aphindwe ngokwawo, aphindaphindiwe kwii-clones ezinobungozi zamaseli e-copycat stem.
Impembelelo yokhulo lokukhusela i-leememia ye-leememia ukulawulwa kwelokukhusela umzimba ukuvelisa okwaneleyo kwimizimba yegazi (eg, i-neutrophils, i-lymphocytes) ukuba isimiso sethu sokuzivikela sifune ukulwa nesifo; ukunikezelwa okuncitshisiweyo kweeseli zamanzi ezimvu kungakhokelela ekudiseni i-anemia, ngokunjalo. Ngaloo ndlela, ukukhuselwa kwintsholongwane kwaye izinto ezinjengobuthathaka okanye ukunyuka kwi-anemia zihlala ziphakathi kweempawu kunye neempawu ze-leukemia.
Ewe, kuvela ukuba kwezinye iimeko ze-leukemia, bekukho utshintsho lomzimba, okanye utshintsho, oluphumela kwinguqu ye-Enzyme TET2 engasebenzi kakuhle. Ngaloo ndlela, isifundo se-2017 sihlolisise iindlela apho le enzyme, i-TET2, inokukhuthazwa ukuba yenze umsebenzi wayo, kwaye ngokukodwa, nokuba i-vitamin C ingasetyenziswanga okanye kusebenziswa kule migudu yokubuyisela imveliso yeseli ephilileyo.
Iziphumo zophando lwe-Vitamin C TET2
Abaphengululi bavelisa iigundane ukuze baqhube i-Enzyme TET2, kwaye bafumanisa ukuba xa i-TET2 ivaliwe, iiseli ezibafileyo zaqala ukungasebenzi, kwaye xa ziphendulela i-gene, ezi zibuhlungu zatshintshwa.
Kwi-leukemia nakwezinye izifo zegazi ezinokutshintshwa ukutshintsha kwezityalo ezichaphazela i-enzyme ye-TET2, kuphela enye yeekopi ezimbini ze-TET2 ishintshi. Abaphandi bajonga ukuba ingaba i-vitamin C iyakwazi ukwenza iikopi ezibi, ezitshintshileyo okanye ezitshintshileyo ze-gene ngokukhuthaza umsebenzi wekopi esasebenza ngokuqhelekileyo. Bafumene ukuba nge-vitamin C, kwakukho ukuxhotyiswa kwindlela yokuvelisa i-TET2.
I-PARP-inhibitors ezifana ne-olaparib ziyizidakamizwa ezifundiswa ukuba zisetyenziswe kwiintlobo ezahlukeneyo zeengqimba zegazi kunye ne-leukemia. Kule sifundo, abaphandi badibanisa i-vitamin C kunye ne-PARP inhibitors kwisimo sabo sezilwanyana ukuze bafunde ukusebenzisana. Bafumene ukudibanisa kusebenza kangcono, okwenza kube nzima nakakhulu kwiiseli ze-leememic ukuzihlaziya.
Kuthiwani Nge-Vitamin C kwiLymphoma?
Njengoko zifunyenwe kwi-leukemia, uphando okwangoku kwinqanaba le-pre-clinical, elithetha ukuba oko sikuyaziyo kuvela kwiimvavanyo zeeseli kunye nezilwanyana kwiibhubhoratri, kodwa kungekhona ngabanye kwizilingo zonyango.
Nangona kunjalo, kukho, ngokusekelwe kule nkcukacha zangaphambi kweklinikhi, izizathu zokukholelwa ukuba iziphumo ezihambelana ne-TET2 kunye ne-vitamin C zingasebenza kwiindawo ezithile ze- lymphoma .
Kwi-lymphoma, iinguqulelo ze-TET2 zifumaneka ngokuqhelekileyo kwi-T-cell lymphomas. Ngenye i-lymphoma subtype, i- angioimmunoblastic T-cell lymphoma , i-TET2 ingatshintshwa kuma-76 ekhulwini kwizigulane. Izinga lokuguquguquka kwe-TET2 liphezulu kuma-38 eepesenti zezigulane ezine-peripheral T-cell lymphoma-engachazwa ngenye indlela, ngokutsho kwesifundo ngo-Lemonnier kunye noogxa, kunye neepesenti ezingama-13 kwi -B-cell lymphoma enkulu .
ILizwi
Nangona izazinzulu zihlenga idatha malunga nevithamini C kunye nenxaxheba yayo ekukhuselweni nasekunyangeni kwamanye amachiza, kubalulekile ukuba i-moderation ekudleni le vithamini. Into eninzi into entle ayikho into enhle. Kwaye, kukusoloko kukulungele ukubonisana nodokotela wakho xa uqala nayiphi na irejimenti eyongezelelweyo enokuphazamisa unyango lwakho.
Akukho bubungqina obunjalo obubonisa ukuba ukuzalisa nge-vitamin C ngokwakho, ngaphaya koko kukhuthazwa, kuya kufikelela ekukhuseleni okanye kunemiphumo enobungcipheko kwi-leukemia okanye i-lymphoma, kwaye ukuzama ukuzimela okunjalo kunokubangela ukuba kubekho ingozi kwiimeko ezithile.
Kwizifundo ezidlulileyo, kuye kwaboniswa ukuba izigulane ezinobungozi be-hematologic zingabikho nto kwi-vitamin C. Ngoko ke, ukulungisa ukulahleka kwe-vitamin C ekhoyo kunokuba yindawo efanelekileyo yokuqala.
> Imithombo:
> I-Cimmino L, i-Dolgalev I, Wang Y, et al. Ukubuyiselwa kwemisebenzi ye-TET2 ibimbela ukuhlaziywa ngokuzenzekelayo nokuvuselela i-leukemia. Cell . Ngo-2017 Agasti 16. pii: S0092-8674 (17) 30868-1. i-doi: 10.1016 / j.cell.2017.07.032. [Epub ngaphambi kokuprinta].
> Lemonnier F, uConneonne L, uParrens M, et al. Iinguqulelo zeTET2 eziphindaphindiweyo kwi-T-cell lymphomas zihamba kunye nezixhobo ezifana ne-TFH kunye neerameter parameters. Igazi. 2012; 120: 1466-1469.
> Mikirova N, Casciari J, Rogers A, et al. Impembelelo ye-dose ephezulu i-vitamin C ene-intravenous ekuvukeleni kwizigulane zomhlaza. J Ukuguqula iMed . 2012; 10: 189.
> Shenoy N, Bhagat T, Nieves E, et al. Ukulungiswa komsebenzi we-TET kunye ne-ascorbic acid kwenza ukuba i-modigenetic modulation yamaseli e-lymphoma. I-Blood Cancer J. 2017; 7 (7): e587-. i-doi: 10.1038 / bcj.2017.65.