I-T4 / T3 I-Thyroid Drug Controversy

Eziqhelekileyo, izikhokelo-ezivunyiweyo zonyango lwe-hypothyroidism yi-hormone ye-thyroid yokutshintshwa ngefomethi ye-thyroid ye-thyroxine (T4). Le thyroxine yokwenziwa komsebenzi iyaziwa ngokubanzi njenge-levothyroxine (kunye ngamanye amaxesha l-thyroxine, okanye i-L-T4). Ezinye zeempawu eziqhelekileyo ziyiSystem, iLevoxyl, iTirosint , ne-Unithroid. Ezi zihlandlo zibizwa ngokuba yi "T4 drugs".

Noko ke, kukho ubungqina obandayo, ukuba ezinye izigulane ze-thyroid aziphenduli ngokusetyenziswa kwe-T4 kuphela, kwaye zenza ngcono ngokudibanisa i-hormone yesibini ye-thyroid, i-triiodothyronine (T3). Ifom yokwenza i-T3 iyaziwa ngokubanzi njenge-liothyronine, kwaye igama legama kwi-US yi-Cytomel. Ezi zibizwa ngokuba yi "T3 drugs".

Iifom zangokwemvelo, ezivela kwizilwanyana ze-T4 kunye ne-T3 nazo zifumaneka kwi-odisti yezilwanyana zonyango ezichanekileyo ze-Thyroid (NDT), ezenziwe kwiingqungqele zengqungqele zeengulube. Amagama e-brand aqhelekileyo aquka i-Nature-throid, i-WP ye-Thyroid, ne-Armor ye-Thyroid. E-US, i-generic yaziwa ngokuba yi-NP Thyroid.

Njengoko kuphawuliwe, umgangatho, unyango oluqhelekileyo lwe-hypothyroidism yi-levothyroxine kuphela. Ukongezwa kwe-T3 kwi-levothyroxine / iT4 kuphela-unyango - okanye ukusetyenziswa kwezidakamizwa ze-NDT-ingquzulwano kunye nesihloko sophando oluqhubekayo kunye nengxoxo. Le ngxabano yonyango iphicothwa ngokubanzi iinkcukacha ezi ngundoqo zilandelayo apha.

I-T3 Iidakamizwa Ukuphucula Ubunjani boBomi

Ucwaningo olwenziwa ngo-1999 oluchazwe kwi- New England Journal of Medicine lubonise ukuba ubomi bobomi babantu abaphathwa ngayo ngenxa ye-hypothyroidism buphuculwe kakhulu kunye nokongezwa kweziyobisi ze-T3 kwi-levothyroxine kuphela.

Abaphandi bathi "unyango kunye ne-thyroxine kunye ne-triiodothyronine luphucule umgangatho wobomi kwizigulane ezininzi."

Kaninzi

2003 I-JAMA Study ithi T3 Inika Akukho Ncedo

I- Journal ye-American Medical Association (i-JAMA) yabika ngo-2003 malunga nesifundo esingavumelani naso esingayifumana inzuzo kwizigulane xa i-T3 yongezwa kwi-T4 kuphela.

Kaninzi

UDkt. Ken Blanchard kwi-T4 / T3 Issue

Emva koDkt. Ken Blanchard, MD, PhD, umbhali wencwadi ethi Yintoni Udokotela Wakho Akunakukuxelela Ngama-Hypothyroidism, wagxotha uvavanyo lwe-JAMA ka-2003.

Kaninzi

I-T4 / T3 unyango olukhethwa ngabagulane kwiSifundo

Umxholo kaMeyi 2005 we- Journal of Clinical Endocrinology kunye neMetabolism yabika ngophando olwalubonisa ukuba abantu abane-hypothyroidism bakhetha inxube ye-T4 / T3 unyango kwi-T4 kuphela yonyango. Abaphandi bafumanisa ukuba unyango oludibeneyo ludibene nokulahlekelwa kwindleko, ngelixa unyango lwe-T4 kuphela.

"Izigulane zikhethiweyo zonyango lwe-LT4 / LT3 oludibeneyo kwilonyango ye-LT4 ... Ukunciphisa ubunzima bomzimba kwahlanganiswa kunye nokwaneliseka ngamachiza okufunda ... isiphumo sale sifundo asikuthinteli ukuba inxalenye ethile yezigulane zinokuzuza kwi-LT4 edibeneyo. / LT3 unyango. "

Kaninzi

Izendalo ezichazwe kwii-Thyroid Izidakamizwa ezibonakala zikhuselekile

Uphononongo olwenziwa ngo-2003 oluqhutywa nguRhulumente waseburhulumenteni wase-US, ukuvavanya izigulane ze-hypothyroid kwiWalter Reed Medical Centre, uxelele ukuba iziyobisi zendalo (i-NDT) ezichongiwe zendalo zikhuselekile kwi-levothyroxine kuphela.

Kaninzi

I-Danish Study Shows Yongeza T3 Ephezulu kwi-T4-Yodwa

Ucwaningo olulandelayo olubhekiselele kwi- European Journal ye-Endocrinology , lubhekiselele kwinkinga enokuphikisana yonyango nge-synthetic T3 njengesongezelelo kwi-T4-kuphela (levothyroxine) unyango lwe-hypothyroidism. Uphando lufumene ukuba ukuhlanganiswa kweT4 / T3 kuphezulu kuneT4 kuphela / levothyroxine unyango lwe-hypothyroidism.

Ukufumana okubalulekileyo:

Ingqikithi ye-49% yezigulane zikhethe ukonyango, kwaye kuphela i-15% ekhetha ukwelashwa kuphela kwe-levothyroxine.

Kaninzi

Ngaba Ufuna T3 Ukuziva Ulungile?

Izigulane ezininzi ze-thyroid zidibanisa nathi apha nakwiphepha le-Facebook leTroroid Support, kwaye ubuze umbuzo ofanayo: "Ndikho kwi-Synthroid (okanye enye i-levothyroxine izidakamizwa ezifana neLevoxyl) kwaye andiziva kakuhle. "U Ziziphi izigulane ze-thyroid ezifunekayo ukuzibuza, kule meko yile: Ngaba unokufumana inzuzo yokongeza kwe-T3?

Kaninzi

Ngaba Ufuna i-T3 okanye i-Natural Desiccated Thyroid?

Ukuba unesifo se-hormone ye-hormone esikhundleni (ie, levothyroxine, okanye i-Synthroid, i-Levoxyl, okanye i-Tirosint brand) kwaye andiziva kakuhle, mhlawumbi unokuzuza xa ungongeza i-T3, okanye uguqula unyango lwe-thyroid olubandakanya iT3 .

Kaninzi

Uphando olutsha

Inqaku elinye eliqinisekisiweyo kwingxoxo malunga ne-T4 kuphela yecandelo le-T3 / T3 yonyango lwe-hypothyroidism luphando olukhulu lophando olucetywayo ngo-2018. Olu pho nonongo luya kubheka iindidi ezahlukeneyo, kuquka ukulingana komgangatho kunye nokugculiswa kwesigulane, kunye kunye ishedyuli yeemvavanyo zegazi, ukuthelekisa i-levothyroxine ne-levothyroxine kunye ne-T3, kunye nokuthelekisa le miqathango emibini kwindlela yokwelashwa kwe-thyroid. Uphononongo luya kuphinda luhlolisise ukuxhaphaka kohlobo lwezofuzo, olubizwa ngokuba yi-polymorphism, elenza ukuba i-T3 iphumelele okanye imfuneko kwezinye izigulane ze-hypothyroid. Le ngxowa-maninzi, i-double-blind, study-review review, eyenzelwe kwaye ilawulwa yizinye ze-endocrinologists ezikhokelayo zesizwe, kwaye iqhutywe ngamaziko aphezulu ezonyango nezibhedlele, ayixhaswa yiinkampani zonyango. Xa iziphumo zipapashwa, olu cwaningo luyakwazi ukutshintsha ngokuphawulekayo izikhokelo ze-hypothyroidism ezisemthethweni, ngokubonisa ukuba i-levothyroxine / T4, iT4 / T3 yonyango, kunye ne-NDT unyango lukhuselekile kwaye lusebenza ngokulinganayo. Uphononongo lungabonisa ukuba ukongezwa kwe-T3 kuphucula umgangatho wobomi kwabanye okanye nokuba uninzi lwezigulane ze-hypothyroid. Uphononongo kufuneka kwakhona lubonise ukuba i-polymorphism yezofuzo idibene nomfuno we-T3 njengenxalenye yonyango. Hlalani nilungele ulwazi oluninzi!