Kukho inzala ekhulayo ekusebenziseni i-nanotechnology kunye nezixhobo ezinobungcali kwiyeza. Izixhobo ezingenakwenzeka ezingenangeniso ezibonisa imiqondiso ebalulekileyo, kwakunye nezixhobo ezingabonakaliyo ezenza iinkqubo zikhululekile, ngoku zihamba ngokubanzi. Enye indawo ebalulekileyo yenkqubela phambili kwi-nanotechnology kukuphuhliswa kwamanoparticles angathatha unyango kwaye atyekele iiseli ezithile okanye izicubu.
Le nano "i-drones" ene-biodegradable inamandla amakhulu kwiindawo ezahlukeneyo zeyeza. Baye baqaliswa kwi- oncology kwaye basebenziselwa ukubuthakathaka ukukhusela i-tumor-cell defense kwiimodeli zemouse. Ngo-2015, iingcali zesifo senhliziyo zasebenzisa nanotechnology ukuhambisa iziyobisi kunye nokulungisa imirhobho , ukuvula indlela yokunyanga i-atherosclerosis ngendlela entsha, mhlawumbi ukuthintela ukuhlaselwa kwentliziyo kunye nemivimbo.
Ukusebenzisa iNanotechnology ukuCombulula ukuvutha
Uphononongo lwemifanekiso yezilwanyana, olupapashwe kwiSayensi yeeNguqulelo zeNzululwazi , lwabikwa ukuba i-drones ye-nano-size ingasebenza ekubuyiseni i-atherosclerotic plaque, okwenza i-plaque ibe yomelele kwaye ingenakwenzeka ukuba iphule ibe yigazi legazi elibulalayo. Abaphandi base-Harvard Medical School, iBrigham kunye neSibhedlele saBesifazane kunye ne-Columbia University bavelise ama-nanomedicines ayenzelwe ukwenza izinto ezichasayo ngqo kwisiza ekujoliswe kuso.
Ukungaboni ukuxazulula ukutshaya kuyinto ebalulekileyo ekuqhubekeni kwezilonda ze-atherosclerotic.
Xa usebenzisa i-nano drones equlethwe izidalwa zonyango ezenziwe kwiprotein ye-anti-inflammatory protocol ye-annexin A1, ukuphuculwa okuphawulekayo kwafunyanwa kwiinkonzo ezine-atherosclerosis. Akukuphela nje ukuvuvukala kuncitshisiwe, imirhoxo yamagundane nayo yalungiswa, inxalenye yonyango ehlukile kule ndlela entsha yeyeza.
Ukulungiswa kwemibhobho ye-coronary eyonakalisiwe ingabaluleke kakhulu ekukhuseleni ukuhlaselwa kweentliziyo kwaye kunokuthintela inani lokufa ngenxa ye-atherosclerosis, eyona nto ibangela phambili yokugula nokufa e-United States. Kuye kucaciswa ukuba inkqubo entsha iya kulungiswa ngokukhawuleza kwaye ivivinywe ngabantu, inika indlela evuyisayo yokuphatha ukuthukuthela kunye nokuhanjiswa kweendawo zep peptides ezijoliswe kuyo.
Abaphandi abavela kwiWeldon School of Biomedical Engineering, iYunivesithi yePurdue, bachaze enye inkqubo yokuphucula ukuvuvukala ngokusebenzisa i-nanotechnology. Baqulunqa inkqubo ye-nanoparticle ehlanganiswayo ye-collagen engasetyenziselwa ukunyanga isifo se-artery. Le ndlela entsha isebenzisa i-nanoparticles ebophelelwe ku-collagen kwaye ikhulule iipepptide ezichasayo. Ezi nanoparticles nazo zinokunciphisa ukuvutha, kunye nokukhuthaza ukuvuselelwa kweethambo ezilinzakeleyo.
Isilonda se-Epithelial Repair with Nanoparticles
Ukulungiswa kwelinxeba ngenye indawo yokwelapha apho i-nanoparticles inokusetyenziswa ngokuphumelelayo ukuququzelela inkqubo yokuphulukisa ngokuqhelekileyo. UGiovanna Leoni kunye noogxa base-Emory kwiYunivesithi basebenzisa i-nanoparticles yokuhambisa iprotheni ye-annexin A1 kwi-mucosa ye-intestinal.
Ukulimala okungapheliyo kwe-mucosal kuyinkalo yezimo ezininzi ezivuthayo zamathumbu, kubandakanya i-ulcerative colitis kunye neemeko zezifo ezithintela kwizigidi ezingama-1.6 zamaMerika. Uphononongo olutshanje lwamagundane luboniswe ukuba ukuhanjiswa okujoliswe kuzo okukhuselweyo kukuphucula inkqubo yokuphulukiswa kweethambo ezilinzakeleyo kwaye kukhuthaza ukulungiswa kwelinxeba ze-epithelial. Kwinqaku lawo, epapashwe kwiNcwadi yePhenyo loPhando , abalobi bacetyisa ukuba ukuhanjiswa kwendawo yeep peptides ngaphakathi kwi-nanoparticles ingaba isicwangciso esitsha sokuthintela abantu abanezifo ezivuthayo (IBD).
Kuye kwaba nentshisekelo ekuphuhlisweni kweenanoparticles zendalo ezinganceda ukuphatha iimeko ezifana ne-IBD. I-nanoparticle etholakala kwi-ginger ezidliwayo yayisetyenziswe ngempumelelo kwisifundo esikhokelwa nguMingZheng Zhang waseYeorge State University, e-Atlanta. I-nanoparticles yemvelo ingakwazi ukunciphisa ubunzima obuhambelana nokuveliswa kweekhemikhali zokwenziwa.
Nanomesh Ukugqoka iiilonda ezingapheliyo
Olunye usebenziso olunokwenzeka lwe-nanotechnology luye lwaboniswa nguMartina Abrigo kunye neqela lakhe labaphandi e-Austin ye-Austin ye-Swinburne University of Technology. U-Abrigo uhlola izicelo zangaphandle zeengqungqutyana ezincinci ukunyanga amanxeba aphethwe yintsholongwane. Udale i-mesh kwi-electrospun i-polystyrene fibers eyenzelwe ukutsala ibhaktheriya kwilonda. I-nanomesh inikeza iimeko ezikhulayo ezikhulayo zebhaktheriya ezinjengeStaplocloccus Aureus kunye ne-Escherichia Coli , ngoko ziyakhonywa kwi-mesh, zishiye isilonda sihlambulukile. Ukuphendula kwama-bacterial kumasheshi e-fiber diameter eyahlukeneyo kwavavanywa ngokudibanisa i-electron microscopy kunye ne-microscopy.
Iibhaktheriya zazithandwa ngokukodwa kwiimfayili ezaziphantse zilinganayo. Iziphumo, ezipapashwe kwi- ACS Applied Materials kunye ne-Interfaces , zibonisa ukuba i-nanofibers ye-electrospiners ingaba yindlela entsha yokulawula amanxeba athathwe yi-bacteria evamile. Kuze kube ngoku, izazinzulu ziye zaqhuba kuphela ukuhlolwa kwe-vitro kunye nokuvavanywa kwimizimba yelungu le-tissue. Nangona kunjalo, kulindeleke ukuba kwixesha elisondeleyo, iimvavanyo ezifanayo ziya kwenziwa kwiimpawu eziphilayo ukuvavanya amandla okule ndlela entsha. Izifundo ze-vivo sele zenziwe ngezinye iindidi ze-nanoparticle ukugqoka iilonda, umzekelo, i-nanoparticles yesilivere enempumelelo.
> Imithombo:
> Abrigo M, Kingshott P, McArthur S. Electrospun i-polystyrene i-fiber diameter echaphazela ukuthintela kubakteria, ukwanda kunye nokukhula. I-ACS Izixhobo zokusebenza kunye ne-Interfaces , ngo-2015; 7 (14): 7644-7652.
> Fredman G, uSolomon S, uPerretti M, et al. I-nanoparticles ejoliswe kuyo equkethe i-peptide ehamba phambili i-Ac2-26 ikhusela kwi-atherosclerosis ephezulu kwiimvumi ze-hypercholesterolemic. I-Science Translational Medicine , 2015; 7 (275).
> Leoni G, Neumann P, Reutelingsperger C, et al. I-Annexin A1 'eneenkcukacha ze-vescelle kunye ne-polymeric nanoparticles zikhuthaza ukulungiswa kwesilonda se-epithelial. Umbhalo woPhando lwezonyango , 2015; 125 (3): 1215-1227.
> McMasters J, Panitch A. Inqaku elide elipheleleyo: I-nanoparticles ebopha i-collagen ye-extracellular anti-inflammatory delivery of peptide i-activation platelet, ikhuthaza ukufuduka kwe-endothelial, nokukhupha ukuvuvukala. I-Acta Biomaterialia , ngo-2017; 49: 78-88.
> Zhang M, Viennois E, Merlin D, et al. I-nanoparticles efunyenwe yi-ginger-derived: Indlela entsha yokwelapha yokuthintela kunye nokunyangwa kwezifo zesibindi esivuthayo kunye nesifo somhlaza. Ii-biomaterials , 2016; 101: 321-340.