I-Fecal microbiota transplantation (FMT) iqhutyelwa uphando njengonyango olufanelekileyo kwiinkalo zempilo ezahlukeneyo, ngokugqithiseleyo ukusuleleka kweClostridium difficile . I-FMT yindlela yokuphucula impilo ye-colonic ngokusebenzisa ukungeniswa kwento engamafetali equlethe iindidi ezahlukeneyo zempilo ebhaktheriya . Njengoko kunikwe ingqwalasela eyongezelelekileyo kwendima yokugulisa ibhaktheriya kwi-IBS , kubonakala kuyimvelo ukubuza ukuba i-FMT iya kuba yinkqubo efanelekileyo ye-IBS.
Makhe sibone ukuba yiyiphi i-FMT, ukuba isebenza njani, kwaye yintoni uphando oluye lwafunyanwa ngokubhekiselele kuluncedo lwe-IBS.
Yintoni i-FMT?
I-FMT, eyaziwa nangokuthi yi-bacteriotherapy, yinkqubo apho umbandela womntu onempilo udluliselwa kwisiginci sesisu somntu ogulayo. Uninzi lwexesha, olu tshintshelo lwenzeka ngexesha le- colonoscopy inkqubo, kwaye ngaphantsi ngokuqhelekileyo ngokusebenzisa ukusetyenziswa. Kwiimeko zamatyala, izinto ziyakudluliselwa usebenzisa ityhubhu yomnxeba engena emathunjini amancinci .
I-FMT inandipha ukwamkelwa okwandayo njengendlela yokhetho oluqhelekileyo ngenxa enkulu yokuphumelela ekuphatheni i- C , kodwa nangenxa yokuba izazinzulu zigxininisa kwiqela elithatyathwa yi-gut dysbiosis kwinani elikhulu leengxaki zempilo. I-FMT ibonakala iyaphumelela ekusebenziseni i-antibiotics, i-prebiotics, kunye neprobiotics ekuphuculeni impilo emzimbeni, ngenxa yokuba into enempilo yefecal iqulethe iindidi ezinobuninzi kakhulu "zobuhlobo" beebhaktheriya.
Yenzani i-FMT?
Njengoko kuchazwe ngentla, i-FMT ibe yonyango lokuqala lweC , ngokukodwa kwiimeko zokuphindwa kwakhona. Ucwaningo lwezenzululwazi luqhutyelwa ukuhlola i-FMT njengonyango olufanelekileyo:
- Izifo ezithintekayo
- Izifo ezizenzekelayo
- Sikashukela
- Isifo se-Metabolic syndrome
- Ukunyanya
Yintoni echaphazelekayo kwi-FMT?
I-FMT ayikwazi kwenzeka ngaphandle kwabanikeli.
Abantu bahlolwe ukuba baqinisekise ukuba banempilo. Abaxhasi banikela ngeesampuli ze-stool eziye zacetywa ukulungiselela inkqubo. Iisampuli ezitsha ngokutsha zisetyenzisiweyo, nangona uphando olwenziwa ngokubhekiselele kwizinto ezinqabileyo.
Njengoko kuthethwe ngentla, i-FMT inokuqhutywa nge-colonoscopy, tube tube, okanye i-enema. Inketho ye-colonoscopy idinga "efanayo" njenge-colonoscopy yendabuko, ukuze kucocwe ikolon.
Imiphumo emibi ye-FMT ngokuqhelekileyo impawu ezinobumba obufutshane-okanye ezingekho. Iziphumo ezingakumbi ziqabile kwaye zenzeka kwinqanaba elifanayo njengoko kukho nayiphi na i-colonoscopy, tube yangasese okanye inkqubo ye-enema.
Ngenxa yokuba isibonelelo se-stool sivela kwelinye umntu, kukho iingxaki ezithintekayo malunga nezifo ezithunyelwa ngabaxhasi ukuba zamukelwe nge-stool (njengeminikelo yegazi, ngaphambi kokuba kwenziwe ukuhlolwa okwaneleyo). Oogqirha nabaphandi bahlakulela imigaqo-nkqubo yokuhlola kunye neenkqubo zokunciphisa umngcipheko.
Ngaba i-FMT Inceda IBS?
Ingcamango ye-FMT ye-IBS iyamangalisa. I-Dysbiosis, imeko engabhubhiliyo yamathambo ezinambuzane eziye zahlanganiswa neengxaki ze-motility kunye ne- visceral hypersensitivity ezenza iimpawu ze-IBS. Ukuba i-FMT yayinokukunceda ukulungisa i-dysbiosis, bekuya kulandela ukuba izigulane ziya kuba nokuncipha kweempawu.
Uphando nge-FMT ye-IBS luqala kodwa lu thembisa. Isifundo esincinane esibandakanya izigulane ezi-13 kuphela ezingazange ziphendule kwizonyango zonyango ze-IBS, zibonise ukuba le nkqubo incede ekunciphiseni iimpawu kwisithuba esiphaya kweyesibini kubathathi-nxaxheba-ngokuphuculwe kuboniswe kwimpawu ezahlukahlukeneyo ezenza i-IBS. Olunye uphando luye lwapapashwa apho izigulane ezingama-45 ezinexilongo ezingapheli zaphathwa nge-FMT kunye ne-enema infemaons. I-89% yabathathi-nxaxheba yabika ukunciphisa ngokukhawuleza kokubanjwa, ukubhubhisa kunye nentlungu yesisu. Iigulane ezingama-30 zabikwa emva kweenyanga ezili-9 ukuya kwe-19 emva kwenkqubo.
Kule 30, ama-60% ayefumana ukunyakaza kwezilwanyana eziqhelekileyo ngaphandle kokusebenzisa i-laxatives.
Ngaphantsi
Kule ngongoma, kwindlela yokuqala kakhulu kumdlalo ukudweba naziphi na izigqibo malunga ne-FMT ukuba ibe yindlela yokwenza unyango efanelekileyo ye-IBS. Kuya kuba lunomdla ukubona ukuba ngaba uphando olusasaza luxhasa ukufumana uphando olululo. Yintoni ebalulekileyo ukuba kuqinisekiswe ukuba le nkqubo inako ukubonelela ngenjongo ecacileyo malunga nezinye iindlela zokwenza unyango ukwenzela ukuba ulungele ixesha layo kwaye uqinisekise ukuba ayinayo ingozi ebalulekileyo yexesha elifutshane okanye ukhuseleko.
Imithombo:
Aaronadis, O. & Brandt, L. "Intestinal Microbiota kunye ne-Efficacy ye-Fecal Microbiota Transplantation kwizifo zesisu" I- Gastroenterology & Hepatology 2014 10: 230-237.
I-Borody, T., uBritht, uL. & Paramsothy, S. "Ulwaphulo lwe-Faecal Microbiota Transplantation: Umoya okhoyo kunye nokuphuhliswa kwexesha elizayo" Umbono okhoyo kwi-Gastroenterology 2014 30: 97-105.
I-Borody, T., Paramsothy, S. & Agrawal, G. "I-Fecal Microbiota Transplantation: Imiqondiso, iindlela, ubungqina kunye nezikhokelo zexesha elizayo" iingxelo ezikhoyo ze-Gastroenterology 2013 15: 337.
Malnick, S. & Melzer, E. "I-Microbiome yabantu: Kusuka kwiHlabathini ukuya kwi-Bedside" I- World Journal ye-Gastrointestinal Pathophysiology 2015 6: 79-85.
Rossen, N., et.al. "I-Fecal Microbiota Transplantation njenge-Articular Treatment kwi-Gastroenterology: Uhlolo lokuHlola." I-World Journal yeGastroenterology 2015 21: 5359-5371.