Ukunyangwa kwangaphambili kwonyango kunciphisa ukuphindaphinda kwendawo kodwa kungekude
Uphando olupapashwe kwiNew England Journal of Medicine lufumene ukuba izigulane ezineesigaba 2 okanye isigaba sesi-3 somhlaza wesibeleko esasifumana i-chemotherapy kunye ne-radiation ngaphambi kokuba utyando lungekho amathuba okuphindaphinda kunezigulane ezithe zafumana i-chemo kunye ne-radiation emva kokuhlinzwa.
Abaphandi bafunda izigulane ezingaphezu kwe-800 ngesigaba sesi-2 kunye nesigaba somhlaza wesi-3 somhlaza.
Phantse isiqingatha safumana i-chemo kunye ne-radiation (i-chemoradiation) phambi kokuhlinzwa kwaye esinye isiqingatha sanikwa i-chemoradiation emva kokuhlinzwa. Ukulandelelana kwesigulane iminyaka emine emva kokuba unyango lufumane inzuzo ecacileyo kwiqela elingaphambi kokuhlinzwa.
Uphononongo lubonisa ukuphindaphinda kweNgqungquthela yeNgqungquthela ye-Rectal ne-Pre-Operative Chemoradiation
Ngokukodwa, i-6% yezigulane ezithe zafumana i-chemoradiation phambi kokuhlinzwa, zaye zaphinda zenzeke, ngokumalunga nama-13% wezigulane ezithe zafumana i-chemoradiation emva kokuhlinzwa. Izigulane kwiqela elingaphambi kokuhlinzwa laphinde lafumana iziphumo ezincinci zonyango, njengoluhudo kunye nokunciphisa isilonda apho ibuye ixhunyiwe emva kokuba isisu sasuswa. Yavumela izinga elongeziweyo lokulondolozwa kwe-sphincter kwizigulane ezinama-tumors aphantsi. Abaphandi abazange babone ukunyuka kokunyuka kwesisu ngokulibazisa ukuhlinzwa kwiiveki ezingama-12 zokuphambi kokuqala kunye nokubuyiselwa kweli qela.
Unyango olunikeziweyo lwaluyi-radiotherapy kathathu ngeveki malunga ne-5040 cGy.
I-chemotherapy eyanikezwa yi-fluorouracil ngexesha leeveki zokuqala nezesihlanu ze-radiotherapy. Kwiqela elonyango lokuqala, unyango lujoliswe kwiiveki ezintandathu emva kokuba kugqitywe unyango. La mabini maqela athola enye imijikelezo emine ye-fluorouracil emva kokuhlinzwa.
Akukho Ukwahlukana kwiiNdawo eziPhezulu eziPhezulu kunye nokuPhepha okuPhezulu kunye nokuPhathwa kweKomoradiation yangaphambili
Nangona ixesha lokwenza unyango lenza umehluko kwimiphumo emibi kunye nemilinganiselo yokuphindaphinda kwendawo, akuzange kubonakale eyenza umahluko xa kufikelele kulondolozo jikelele okanye ithuba lokuba umhlaza uza kusasazeka kwicandelo elithile lomzimba. Kwakunjalo kumaqela amabini.
Uluphi oluhle lo uphando kuwe?
Ukuba unokufumana utyando lwesigaba sesi-2 okanye isigaba sesi-3 somhlaza wesifo somhlaza, unokufuna ukuthetha nodokotela wakho malunga nokufumana i-chemotherapy kunye ne-radiation ngaphambi kokuba utyunjwe kunokuba ulandele. Ngokwale cwaningo, ukwenza njalo kunokunciphisa amathuba akho okuphindaphinda kwendawo kwaye uphucule umgangatho wakho wobomi ngexesha nangemva kokunyanga.
Uphando olufanayo
- I- oes I-Anesthesia Choice ithinteka njani kwiColon Cancer Survival ? Abaphandi bajonga ukuba iintlobo ezahlukahlukeneyo ze-anesthesia zinefuthe kwizinga lokuphindaphinda. Izifundo malunga neminyaka zinezigqibo ezihlukileyo.
- Ziziphi Izinto Ezichaphazela Ukusinda Kwemhlaza Yomhlaza? Fumana oku ngakumbi malunga noko kuthetha ukuthathwa ngolu mhlaza kunye noko ungalindela ukusinda.
- Ngaba Kukho Uhluko phakathi kweCaron Cancer kunye neColorectal Cancer ? Amagama amabini abonakala esetyenziswe ngokungaqhelekanga, kodwa ngaba kukho ukungafani? Yintoni omele ucinge ngayo xa ubona isigama esinye okanye enye kwaye kuthetha ntoni kuwe?
- Yiyiphi i-Number One Risk Factor yeCaron Cancer ? Fumana okunye malunga nobungozi ongenza okuthile malunga neengozi ongenako.
Imithombo
Iziphumo zovavanyo lweCliniki: I-Chemoradiation Ngaphambi kokuvuthwa kunceda ukukhusela ukuhlaselwa kweNgingqi yeCarcer Rectal. National Cancer Institute. 26 Agasti 2006 [http://www.cancer.gov/clinicaltrials/results/pre-op-rectal1005/print?page=&keyword=].
Sauer, R. noBrakker, H. "I-Chemoradiotherapy ye-Preoperative versus Postoperative ye-Postoperative ye-Rectal Cancer". I-New England Journal of Medicine 351.17 (Oktobha 2004): 1731-1740. 26 Agasti 2006 [http://content.nejm.org/cgi/content/abstract/351/17/1731].