Iimpawu ze-CAH zingenza i-Mimic PCOS
Xa uqwalasela ukuxilongwa kwe-polycystic ovary syndrome (i- PCOS ), kubonakala ukuba ugqirha ukuba acinge ngokukhawuleza kokuqala kokuzalwa kwe-adrenal hyperplasia (CAH), naye. Kungenxa yokuba ezi zifo zihlala zibonisa iimpawu ezifanayo.
Ukuza kusasa kwe-Congenital Adrenal Hyperplasia
I-congenital adrenal hyperplasia yiqela elizuze ilifa lezifo apho i-enzyme eyona nto ilahlekile emzimbeni.
Iintsilelo ze-Genetic ezikhoyo ngexesha lokuzalwa (ukuzalana) zichaphazela ii-enzyme eziliqela ezifunekayo ukuvelisa ama hormone e-adrenal corrox.
Phantse ama-95 ekhulwini lwee-CAH zibangelwa ukungabikho kwe-enzyme 21-hydroxylase. Umzimba awukwazi ukwenza ixabiso elaneleyo ezimbini ze-adrenal steroid hormones-cortisol kunye ne-aldosterone-xa i-enzyme 21-hydroxylase ilahlekile okanye isebenza kwinqanaba eliphantsi. Oku kulahla ukulinganisela kwe-hormone, ukukhusela ukuhlanganiswa okufanelekileyo kwe-aldosterone kunye ne-cortisol, kunye ne-corrox e-adrenal iqala ukwenza i-androgens (i-hormone yamadoda e-steroid), ekhokelela kwiimpawu zamadoda kuma-females. Kulo hlobo lwe-classic ye-CAH, ukulinganisela ityuwa kunokuguqulwa ngokukhawuleza, okukhokelela ekungalingani kwe-electrolyte, ukutshatyalaliswa kwamanzi kunye nokuguqulwa kwesiginci senhliziyo.
Nangona izigulane ezininzi zifumanisa ukuba kungekudala emva kokuzalwa, kukho uhlobo lwesifo esiya kudala ebomini, ngokuqhelekileyo ebusheni okanye ekukhuleni kwabantu abadala-kuthiwa yi-classic okanye i-CAH ekuhambeni kwexesha.
La bantu balahleka kuphela ezinye ze-enzyme eziyimfuneko ekuveliseni i-cortisol. Ukuveliswa kwe-Aldosterone akuchaphazelekayo, ngoko le ndlela yesifo ayinamandla kakhulu kunokuba ifom ezalweni kwaye ibonisa iimpawu eziphambukayo kwi-PCOS, njenge:
- Ukuphuhliswa kwangaphambili kwesikhumba se-pubic
- Ixesha eliqhelekileyo lokuya esikhathini
- I-Hirsutism (iinwele ezingafunekiyo okanye ezingaphezulu kweenwele)
- I- acne enkulu (ebusweni kunye / okanye umzimba)
- Iingxaki zenzalo kwi-10% ukuya kwi-15 ekhulwini yabasetyhini abaselula abane-CAH
Ukuxilongwa kweCAH
I-congenital adrenal hyperplasia idluliselwa ngofuzo. AmaYuda aseMpuma Yurophu (iAshkenazi) inomngcipheko wokwanda kwesi sifo, xa kuthelekiswa noluntu jikelele. Ekubeni i-CAH isifo sesigxina sokuzimela , bobabili abazali kufuneka baphathe impawu enzyme ephosakeleyo ukuze bayidlulisele kumntwana wabo.
Ngenxa yokudluliselwa kwemfuyo kwimeko, abantu abaninzi bayazi ingozi kwiintsapho zabo kwaye baxelele ugqirha wabo ukuba bafuna ukuhlolwa kwesimo somzimba. Ugqirha unokusebenzisa umchamo kunye nokuhlolwa kwegazi ukujonga amazinga okungaqhelekanga kwama-cortisol okanye amanye amazinga e-hormonal. Amanqanaba e-androgen enyukayo anokuqwalaselwa xa esenza ukuxilongwa. Ingxelo epheleleyo yentsapho kunye nokuhlolwa ngokomzimba kuyimfuneko ukuba ugqirha enze i-diagnostic epheleleyo.
Izinyango Zonyango
Iipilisi zokulawula ukuzalwa zihlala zisebenza kakuhle ekulawuleni umjikelezo wesini, ukunciphisa i-acne, ngamanye amaxesha ukulahleka kweenwele ezingavamile. Ukuba oku kusebenzayo ekujonganeni neempawu, okanye ugqirha unomuvo wokuthi ukulawula iipilisi akukufanelekanga, unokucinga ukuba unika unyango lwe-steroid ephantsi.
Nangona kunjalo, unyango aluqhelekanga.
Kwabantu abane-CAH yeklasi kunye nokuntuleka kwe-aldosterone, isilwanyana esinjenge-fludrocortisone (i-Florinef) siya kugcina ityuwa emzimbeni. Iintsana nazo zithola ityuwa eyongezelelweyo (njengamacwecwe okanye iisombululo ezityunjiweyo), kanti izigulane ezithe zadala zihlobo lweCAH zidla ukutya okunomsoco.
Isilwanyana esithile kunye ne-regimen ngokuqhelekileyo kuya kwiqondo logqirha kwaye lixhomekeka kubunzima beempawu.
> Umthombo:
> I-National Adrenal Diseases Foundation. I-Adrenal Hyperplasia (CAH) ye-Congenital Hyperplasia.