Uninzi oogqirha basebenzisa ukucebisa ukubukela indlela odla ngayo inyama, amaqanda, kunye nemveliso yamachiza ephezulu ngenxa yamanqanaba aphezulu eoli kunye ne-cholesterol. Ukutya okunamafutha amaninzi kunokuphakamisa amanqanaba e-low-density lipoprotein ( LDL ) ye-cholesterol, i-cholesterol "engalungile" kunye nohlobo olubandakanyekayo ekunyuseni umngcipheko wesifo se-cardiovascular and consequences, njenge-heart attack and stroke.
Kodwa isantya soqhagamshelwano phakathi kwamafutha okutya kunye ne-cholesterol nesifo senhliziyo sele sisandululwa. Namhlanje, siyazi ukuba ininzi ye-cholesterol ikhiqizwa sisibindi kwaye i-15 ukuya kwi-20 kuphela iipesenti iphuma ekudleni kwakho.
Oku kufunyenweyo akuyikho ilayisenisi yokutya kwi-bacon, amaqanda, kunye ne-toast buttered. Iingcali ziyacetyisa ukuba udle oku kutya ngokumodareyitha. Nangona ezi zinto zingenakuphakamisa i-cholesterol yakho njengoko yayicinga ngaphambili, iyakuchukumisa impilo yakho ye-cardiovascular ngendlela eyahlukileyo.
Ucwaningo lufumene unxibelelwano oluchanekileyo phakathi kweemveliso zamakhemikhali ezenziwe emathunjini xa oku kutya-eziqhelekileyo ekudleni kweNtshona-kudliwa kunye nokuvela kwintliziyo yesifo, ukuphazamiseka, ukuhluleka kwentliziyo, nokufa, iziphumo eziphambili zesifo senhliziyo .
Ukugonywa kubalulekile
Ubulunga bethu buxhamla neebhaktheriya ezisebenzayo njengesihluzo sethu sokungcola kwendalo-ukutya esikudlayo.
"Yintoni esiyondla ngayo iibhaktheriya ngexesha elichaphazelayo eyenzekayo kuyo yonke imizimba yethu," kusho uStanley Hazen, MD, Ph.D. , ICandelo leNtloko yeCardiology yokuVimba eKliniki yaseCleveland, oye waqhuba uphando lwesikhungo kule ndawo.
I-laboratories kaDkt. Hazen yaqhuba uphando oluphambili ekufumaneni ikhonkco lokusebenzisana phakathi kwamagciwane kunye nesifo senhliziyo nge-substance ebizwa ngokuthi i-trimethylamine- N- oxide (TMAO).
I-TMAO yakhiwa kwizondlo ezifumaneka kwizixhobo zezilwanyana.
Ezi zifundo, kunye neziphumo eziphambili ezifunyanisiweyo, kubonise indlela ezinye iintsholongwane ezintsheni eziguqula ngayo i-choline-iproduct ye-lecithin efunyenwe kwinyama, izikhupha zeqanda kunye nemveliso yamachiza ephezulu e-trimethylamine (i-TMA), echithwa kwigazi kunye ne-metabolized ngesibindi. Kukho, i-TMA iguqulwa ibe yi-TMAO, ebonakala ngathi ngumdlali oyintloko kwiinkqubo zesifo ezinxulumene nentliziyo kunye neendonga zegazi.
Ngaphezu koko, ezi zifundo zibonise ukuxhamla okucacileyo phakathi kwamazinga aphezulu e-TMAO kunye namazinga aphezulu okuhlaselwa kwintliziyo, ukushaywa yintlungu kunye nokufa phakathi neminyaka emithathu kubantu, kunye nesifo senhliziyo esiphuthumayo kwimifanekiso yezilwanyana.
I-lab ye-lab yaseHazzen yabonisa ukuba inxaxheba efanayo ye-microbe-based process inegalelo kwisifo senhliziyo esiphuthumayo emva kokungenwa kwe-L-carnitine, isakhi esifumaneka ngokwemvelo kwizilwanyana ezininzi ezibomvu kodwa kwakhona sisongezwa rhoqo kwiziphuzo zamandla. Uphononongo lufumene ukuba umthambo uphinde uphenduke i-L-carnitine kwi-TMA (kunye ne-TMAO) kwaye i-TMAO incedisa kwisifo senhliziyo ngokuyinxalenye ngokutshintsha indlela umzimba usebenzisa ngayo i-cholesterol. I-TMAO nayo yaboniswa ekubangela ukuvuvukala emitanjeni yegazi kunye nokudala iiplati ezingakhawulezileyo kwiindonga zetyitha, ngaloo ndlela ziphakamisa umngcipheko wokuhlaselwa kwentliziyo.
Ukumelwa yintliziyo
Uphando olongezelelweyo liqela leDkt. Hazen libonise uqhagamshelwano phakathi kweTMAO kunye nokuhluleka kwentliziyo. Xa behlolisisa indima ye-TMAO kwizigulane ezinokusilela kwenhliziyo, zafumanisa ukuba izinga eliphezulu le-TMAO, umngcipheko wokufa komoya.
"Lo mngcipheko wubunyaniseka ngaphandle kweminye imingcipheko yendabuko kwaye kungakhathaliseki ukuba iinjongo zisebenza okanye ngabaphawuli begazi abonakalisa intlungu yenhliziyo," kusho uDkt. Hazen. Kule sifundo, amazinga aphezulu e-TMAO aphezulu ngaphezu kokuphindwe kathathu umngcipheko wokufa.
Izifo Zengqondo
Imiba yemingcipheko yendabuko ayiyi kuba neengxaki zokunyuka kwengqondo kwimeko yezigulane ezineentsholongwane eziphosakeleyo (iimeko ezibizwa ngokuba zizifo ezingasasigxina kunye nesifo sokuphela kwesigulo).
Iqela likaDkt. Hazen lafumanisa uxhulumaniso phakathi kweTMAO, isifo sesifo, kunye neengozi zempilo yengqondo eziye zaphawulwa ngabantu abajongene neengxaki zezintso. Ukongezelela ekuboniseni ikhonkco phakathi kwe-TMAO kunye neengozi eziphezulu zeengqondo kwizinto ezichaphazelekayo zentsholongwane, bafumene (kwiimodeli zezilwanyana) ezidlayo ukwandisa amanqanaba e-choline ngokutya kunye nokufikelela kumazinga aphezulu eTMAO ngokuhamba kwexesha kubangela ukubunjwa kweethambo (fibrosis) ezintso. Oku kunokubangela ukuba umsebenzi wezintso uhlahloke.
Kwisifundo esithile, uDkt. Hazen wabona abantu abanengxaki yesifo ngenxa yesifo seminyaka emihlanu. Wafumanisa ukuba abo abanamazinga aphakamileyo e-TMAO xa isifundo saqala sasinokwenzeka ukuba sinciphise ngokukhawuleza kwimisebenzi yengqondo, ukuhlaselwa intliziyo, ukubetha okanye ukufa-xa kuthelekiswa nalabo abanezinga eliphantsi le-TMAO.
Ukongezelela, njengoko umsebenzi weentso uyancipha, amazinga e-TMAO akhuphuka ngenxa yokuba i-TMAO ikhutshwe yizintso. "Amanqanaba aphezulu e-TMAO aqwalaselwe angachaza ukuba kutheni abantu abaneengxaki ezinzulu zesifo bavame ukwanda kwengozi yokufa ngesifo senhliziyo," kubika uDkt. Hazen.
Uphando olungakumbi kunye neziphumo
I-lab yeLebhu yaseHazzen iyaqhubeka nokuphanda indima ye-TMAO kwezinye iinkqubo zesifo. Uphononongo oluya kumhla luqinisekisa ukuba izilwanyana ezinqamlekileyo, ngokusebenzisa isizukulwana se-TMAO, ngumdlali oyintloko kwimpilo yengqondo. Oku kutshanje, uphando olusuka kwi-lab ye-lab ye-TMAO kwingqungquthela yesifo somzimba-isifo somlenze womlenze-kunye nokubunjwa kwegazi lokubangela ukuhlaselwa yintliziyo kunye nokubetha.
Ukufumanisa ukuba ama-microbridge kunye neTMAO inxulunyaniswa nempilo ye-cardiovascular ivulela umnyango wezinto ezininzi ezinokwenzeka. Ukuphuculwa kweziphakamiso zokutya kunye nesondlo kuyinto ebonakalayo. Enye kukuba ukuqonda le ndlela kuholele kwiimvavanyo ezintsha zokuxilonga kunye nokunyanga okujoliswe kwiinkqubo ze-microbe ezifaka isandla kwisifo senhliziyo.
Iingxoxo zokuphayona ngeqela likaDkt. Hazen libonise ukuba ukujoliswa kweyathelo lokuqala ekudalweni kwe-TMAO-ukuveliswa kwe-TMA, eguqulwayo ibe yi-TMAO ngamagciwane-kunokunceda ukuthintela i-atherosclerosis (ukuqina kemithambo) kwimifanekiso yezilwanyana. Le ndlela entsha inamathemba ekusebenziseni kwayo okokugqibela njengonyango lokukhusela intliziyo, ukuphazamiseka, kunye nezinye iimpawu ze-atherosclerosis.
Ngokomzekelo, xa amagundane atyiswa ukutya okucebile kwi-choline okanye i-carnitine (efana nokutya kweNtshona), bafumana i-atherosclerosis esheshayo. Xa isiqingatha seentlanzi kwi-high-choline yokutya zanikwe into eyenziwa ngokwemvelo ekhusela indlela eyimilenze ekhokelela kwi-TMAO, i-atherosclerosis engaphantsi. Isilwanyana esingokwemvelo esetyenziswe kwiimiceba, esifumene kwioli yomnquma esineqanda, kunye neoli yembewu yamagilebhisi, ibonakaliswe ukuba ikhuselekile kakhulu, kwimiqathango ephezulu.
Yintoni oku kuthetha ngayo kuwe
Ubungqina obutsha budibanisa iimbulunga zamagciwane ukuya kwi-metabolism kunye nentliziyo yempilo. Kwaye ukutya kukunye okubalulekileyo okuchaphazela ukubunjwa kwe-microbe kunye nokusebenza. Izifundo, ukuya kutsho, zibonisa ukuba ukutya ukutya apho umntu adla khona inyama kunye nemveliso yezilwanyana, njengento yokutya yemifuno okanye ye-vegan kunye nokutya kweMedithera, kunokuncedisa ngokukhethekileyo, ingakumbi ukuba unobungozi obukhulu bentliziyo, ukungaphumeleli kwentliziyo, okanye isifo esingasasigxina sesifo, "kusho uDkt. Hazen.
Ngokubhekiselele kuthi, sonke sichaza ukuba kunzima ukusho nokuba okanye ukusika okanye ukusika inyama ebomvu, ubisi kunye namaqanda kunokusinceda siphile ubomi obude, ubomi obuphilileyo. Nangona kunjalo, uvavanyo lwegazi lwe-TMAO lukhoyo ngoku kwaye uDkt. Hazen uqaphele ukuba lunokunceda izigulane ngamnye ukuba zibone ukuba izinga lakhe le-TMAO liphezulu kangakanani. Ukwazi iqondo lakho le-TMAO linganika umfanekiso ocacileyo weengozi yakho yengqondo, "utsho.