I-CHOP ligama elichanekileyo lokudibanisa amayeza ahlukeneyo. I-CHOP yenye yezona zidibaniso eziqhelekileyo zonyango ezisetyenziselwa i -Hodgkin lymphoma, okanye i-NHL . I-CHOP isetyenziselwa ezinye iintlobo ezixhaphakileyo kunye neNHL . Iqukethe imithi emine eyahlukileyo: i-cyclophosphamide (i-Cytoxan), i-doxorubicin (i-Adriamycin), i-vincristine (i-Oncovin) ne-prednisone.
I-CHOP ihlala idibene kunye ne-rituximab kwi- R-CHOP .
Izidakamizwa zokuqala ezintathu ze-CHOP i-chemotherapy regimen zidlalwa njengama-injections okanye i-infusions ye-veins ngosuku olunye, ngelixa i-prednisone ithathwa njengeipilisi iintsuku ezintlanu. Ngokuqhelekileyo, i-regimen eyaziwa ngokuba ngu-R-CHOP inikwa ngeentshukumo ezintathu kwiiveki ngaphandle kweeyure eziyi-6-8.
Amachiza anikwa kwi-CHOP ukulwa namaseli omhlaza ngemizila eyahlukileyo. Xa i-cyclophosphamide isetyenziselwa nje ngokuba ngumhlaza wekhemotherapy kwi-CHOP, isebenza ngokucotha okanye ukuyeka ukukhula kwamaseli omhlaza emzimbeni wakho. Ingaba nomonakalo othile wokubambisa kwinto yokuba ithintela ngokukhawuleza iiseli emzimbeni onempilo, njengalezo ezivelisa iinwele kunye nazo ezikwindawo yokulahleka kweenwele kunye neempawu zamathumbu ezinokuthi ziyimiphumo emibi.
U-Doxorubicin useklasini yemithi ebizwa ngokuba yi-anthracyclines, kwaye isebenza ngokucotha okanye ukuyeka ukukhula kwamaseli omhlaza.
UVincristine usebenza ukukhusela iiseli zeomhlaza ekuphinda ziphindiwe, ngokuyinxalenye ngokuhlasela ukutshitshiswa kweetayiti elalisetyenziselwa ukwahlula. Iiseli zomhlaza zithinteka kakhulu kwi-chemotherapy kuneeseli eziqhelekileyo, kodwa i-chemotherapy nayo inefuthe kwiiseli eziqhelekileyo, okubangelwa kwiprofayili echaphazelekayo yecala.
I-Lymphomas Ejongene Ne-CHOP + Rituximab
I-Cyclophosphamide, i-doxorubicin, i-vincristine, ne-prednisone (CHOP), ibe yinto ephambili yonyango iminyaka emininzi kwizigulane ezine-B-cells lymphoma enkulu (DLBCL). Uninzi lwezigulane ezine-DLBCL zinokunyangwa nge-rituximab + ejwayelekile, i-cyclophosphamide, i-doxorubicin, i-vincristine, ne-prednisone (R-CHOP), nangona kunjalo, iziphumo azilungele abo bangenzi kakuhle kule regimen.
I-CHOP i-chemotherapy isetyenziselwa ezininzi iintlobo eziqhelekileyo ezingenalo i-Hodgkin lymphomas, kuquka ne-angioimmunoblastic T-cell Lymphoma, kunye ne-T-cell lymphoma. I-protocol ye-R-CHOP ifanele ibe yinkqubo yokunyangwa kobugwenxa, iSigaba seNqanaba kunye neNqanaba eliQilileyo leNqanaba lesiBili le-NHL kunye neNHL.
Ulawulo kunye nemiqathango
U-Adriamycin udlalwa kuqala njengokuba kunokucaphukisa imithwalo yegazi. Kubalulekile ukuba uxelele unesi-infusion xa uziva uvutha okanye intlungu kwi-site yokungena . Ngomhla ofanayo, uya kunikwa ngamachiza amabini alandelayo, i-Cytoxan kunye neVincristine.
Ikliniki iya kucetyiswa ukuba unomqhubi ukuba akuyise ekhaya emva kwonyango. Unokubona utshintsho kwimbala yomchamo wakho kumbala obomvu we-Adriamycin iintsuku ezimbalwa emva kokuba unyango.
Iziphumo eziPhakathi
- Ukulahleka kweenwele: Uya kuba nokulahleka kweenwele ezipheleleyo, kuquka iinwele entloko yakho kunye neenki, i-eyelashes, kunye neenwele zomzimba. Ngokuqhelekileyo, oku kuqala ezimbini kwiiveki ezintathu emva kokunyanga, kodwa okwethutyana kunye neenwele zakho kufuneka zibuye emva kwonyango.
- Isisindo kunye nokuhlanza ziqhelekile, ukususela emva kwangoko unyango emva kweentsuku ezintathu emva kokunyanga.
- Ukugqithwa kuqhelekile ngenxa ye-vincristine kunye namanye amayeza adlalwa ngokunyamezela kunye nentlungu.
- Izilonda zomlomo zingabonakala ngeveki kwiiveki ezimbini emva kokunyanga.
- Imiba yokunqongophala: Abasetyhini banokuphazamiseka kwemizila yabo yokuya esikhathini kwaye banokungena ngokusisigxina. Amadoda anokuyeka ukuvelisa isibini, ukunciphisa ukuzala. Le miqathango inokuhlala isigxina, ngoko kufuneka uxoxe ngeendlela zokuzala kunye nodokotela wakho ngaphambi kokuqala unyango. Ngakolunye uhlangothi, ungacingi ukuba awuyi kuba nefuthe ngexesha lokunyanga, sebenzisa ukukhulelwa komzimba ukukhusela ukukhulelwa.
- Unokuba lunyanzelekile xa usufumana unyango ngexesha le-CHOP unyango njengoko liza kunciphisa okwethutyana iiseli zegazi ezimhlophe kunye neeseli ezibomvu, ziphazamise isimiso sakho somzimba. Kuqikelele ukuphepha ukudibanisa nabantu abandayo okanye umkhuhlane kunye nokuhlamba izandla rhoqo ukukhusela intsholongwane okanye intsholongwane.
- I-Prednisone iyi-steroid kwaye ineempembelelo ezininzi ezinokubakho, kuquka ukuguquka kwemizwelo, ukufumana ubunzima, nokuvuvukala.
> Imithombo:
> Sehn LH, iGascoyne RD. Ukusasaza i-cell-cell lymphoma enkulu: ukwandisa isiphumo kumxholo we-clinical and biologic heterogeneity. Igazi. 2015; 125 (1): 22-32.
> Imiphumo engasetyenziswayo yeCyclophosphamide, i-Doxorubicin, i-Vincristine, ne-Prednisone (CHOP), iNational Cancer Institute, uNovemba 27, 2013.
> I-Adult Non-Hodgkin Treatment Lymphoma-yezempilo (PDQ®), iNational Cancer Institute, ngoJanuwari 15, 2016.