Ukuba uhlala nemeko efana ne-osteoarthritis okanye ukudandatheka, usenokuba uyayazi ukuba inokuchaphazela njani ezinye iinkalo zempilo yakho, ekuncedeni kwimicimbi efana nokuzuza ubunzima, ubunzima bokulala, nobuhlungu obungapheliyo.
Esinye isiluleko esicacisiwe sokunciphisa uxinezeleko, isifo samathambo, kunye nezinye iimeko, i-SAMe eyongeziweyo, eyaziwa ngokuba yi-SAM-e, i-ademetionine, okanye i-S-adenosylmethionine.
I-SAM yindlela yokwenziwa komgangatho oveliswa ngokwemvelo emzimbeni ukusuka kwi-methionine (i-amino acid ebalulekileyo) kunye ne-adenosine triphosphate (i-composite-producing output).
I-SAM ayifumanekanga ngokwemvelo ekudleni. Umzimba ukwenza oko kukufunayo impilo enempilo, nangona kunjalo, esinye isifo sithi amazinga aphantsi e-methionine, i-folate, okanye i-vitamin B12 zikholelwa ekubeni zinegalelo kumazinga aphantsi a-SAMe.
Kucinga ukuba i-SAMe inokukunceda ukuveliswa kwemveliso yamachiza eyaziwayo ukuba idlale indima ebalulekileyo kwiinkqubo ezahlukeneyo emzimbeni, njengomgaqo-mood, ukusebenza komzimba kunye nokuqonda intlungu.
Kutheni abantu bethatha ii-SAMe Supplements?
I-SAM isetyenziswa kakhulu kule micimbi yempilo elandelayo:
- Ukuxhalabisa
- Ukuxinezeleka
- Fibromyalgia
- Osteoarthritis
- Ubuhlungu
- I-Premenstrual syndrome (PMS)
I-SAMe kuthiwa yandisa intsebenzo yengqondo, ikhulise impilo yebindi , iphucise inkqubo yokuguga, kwaye inceda abantu bayeke ukutshaya.
Izinzuzo: Ngaba Unokunceda ngokwenene?
Nanku ukukhangela kwezinye zophando malunga neenzuzo ezinokwenzeka ze-SAMe.
1) I-osteoarthritis
U-SAMe ubonisa isithembiso kwonyango lwe-osteoarthritis yamadolo okanye i-hip. Kuthiwa ukunciphisa intlungu kunye neendawo ezichasayo, kwaye uphando oluthile lubonisa ukuba luyakhuthaza ukulungiswa kwe-cartilage.
Ingxelo epapashwe kwiDatabase yaseCchrane yeeNkqubo eziPhezulu ngo-2009, abaphandi bahlalutya izilingo ezine ezipapashwe klinikhi (kunye nabathathi-nxaxheba abangama-656) kwaye bafumanisa ukuba ukusebenzisa i-SAMe kunokuncedisa ukunciphisa intlungu kunye nokuphucula umsebenzi kubantu abane-osteoarthritis.
Ekubeni iilingo ezihlolisisiweyo ziphantsi kobunzima, nangona kunjalo, abalobi bahlalutyo babona ezi ziphumo zingenakulinganiswa.
2) Ukudandatheka
Kuphando oluphando olupapashwe kwiDatabase yeCchrane yeeNkqubo eziPhezulu ngo-2016, izazinzulu zahlalutya izilingo ezisibhozo ezishicilelwe ngaphambili ezichazwe kwi-SAMe kwi-anti-depressants imipramine, desipramine, okanye i-escitalopram, okanye i-placebo.
I-SAM yayiphezulu kune-placebo xa isetyenziselwa i-serotonin reuptake inhibitor (SSRI) yokudandathelana, kodwa ubungqina babonwa njengomgangatho ophantsi. Xa kuthelekiswa nemipramine, abathathi-nxaxheba abambalwa banemiphumo emibi xa baphathwa ngefom ye-SAMe. I-SAM yayingavaniyo ne-placebo okanye i-anti-depressants ezifana ne-imipramine okanye i-escitalopram xa isetyenziswe yedwa.
Ekupheliseni kwabo, abalobi bahlolisayo bathi ukusetyenziswa kwe-SAMe yokudakumba kufuneka kuphandwe kwakhona kwiilingo ezinkulu kunye nezicwangciswe bhetele "ngenxa yokungabikho kobungqina obuphezulu kunye nokungakwazi ukufumana izigqibo eziqinileyo ngokusekelwe kuloo bungqina."
3) I-Fibromyalgia
Kuphando oluphando olupapashwe kwiNcwadi yoLondolozo lwezeMpilo kunye noNyango oNye ngo-2010, izazinzulu zikhangele kwiimvavanyo ezingama-70 ezazisishicilelwa ngaphambili ezazihlola ukusetyenziswa kweentlobo ezahlukeneyo zokwelapha ezidityanisiweyo zesifo esingapheliyo kunye ne-fibromyalgia.
Kanye kunye ne-magnesium, i-L-carnitine, i-acupuncture, kunye neentlobo ezininzi zeendlela zokucamngca, abalobi abahlaziyiweyo bathiwa ngu-SAMe phakathi kweendlela zokwenza uphando olongezelelweyo malunga nokusebenza kwazo kule miqathango.
4) Izifo zesibindi
I-SAMe inokuphucula umsebenzi wesibindi kubantu abanesifo esingasasigxina sesibindi, iphakamisa uphando oluphandwayo kwiphepha le- PLoS One ngo-2015. Nangona kunjalo, ekuphononongweni kwezilingo ezili-12 ezishicilelweyo ngaphambili ezibandakanyiweyo ekuhlaziyweni, abalobi baye bafumanisa ukuba i-SAMe inokuthi ifumane inzuzo encinci ekunyanga kweemeko ezithile zesibindi ezifana ne-virus ye-hepatitis ne-cholestasis.
Iimiphumo zangaphandle
I-SAM inokubangela imiphumo emibini, kuquka ukuxhalaba, ukumbombola, isifo sohudo, umlomo owomileyo, intloko yesifo, ukuguquka kwentliziyo, ukungabonakali, i-gesi, ishukela ephantsi yegazi, isisulu sokuncwina, ukukhathazeka, ukugqithisa isikhumba kunye nokuhlanza. Inani elikhulu le-SAMe linokubangela i-mania (iimoya ephakamileyo ngokungavamile). Kukho nkxalabo yokuba ukusetyenziswa kwe-SAMe kunokubangela ukuphendulela kwabanye abantu.
Ukuba unentsholongwane ye-bipolar, i-Lesch-Nyhan syndrome, isifo sika-Parkinson, okanye ezinye iimeko zempilo, kufuneka usebenzise kuphela i-SAMe phantsi kweliso lomniki-nkonzo wakho wezempilo njengoko kunokuba lunokuba nzima ngakumbi.
Kubalulekile ukuba uqaphele ukuba kukho ingozi xa udibanisa i-SAMe kunye neyeza okanye ezinye izongezo. Akufanele uthathe i-SAMe ngokudibanisa ne-anti-depressants, imithi yokukhwehlela, isifo sikashukela, i-levodopa (L-dopa), i-tryptophan, amayeza anokuchaphazela amanqanaba e-serotonin, i-wort yaseJohan, okanye enye imithi ngaphandle kokuba uhlolwe yimpilo bugcisa. I-SAM kufuneka ichithe ubuncinane ubuncinane kwiiveki ezimbini phambi kokuhlinzwa okucwangcisiweyo.
Ukhuseleko lwe-SAMe kubantwana, abafazi abakhulelweyo okanye abahlengikazi, okanye abantu abanesifo okanye isifo sesibindi akazange kusekwe. Unokufumana iingcebiso ekusebenziseni izongezo ngokukhuselekileyo , kodwa kufuneka uthethe nomboneleli wakho oyintloko ngaphambi kokuba uthathe i-SAMe ukuba uxoxe ukuba kulungile kuwe. Gcina ukhumbule ukuba i-SAMe ayifanele isetyenziswe njengenxalenye yonyango oluqhelekileyo.
ILizwi
Ukuphila kunye nayiphi na imeko engapheliyo akulula. Nangona ezinye iingcaphephe zibonisa ukuba i-SAMe inokunikela ngezibonelelo ezithile, asikwazi ukuqina ngokuphathelele uxhamlwano kude kube yilungelelwano olubanzi, uvavanyo olunzulu lwezonyango (uhlobo lophando ofuna ukulufumana ukubeka isisithi esigcwele kunyango) .
Kwakhona kubalulekile ukugcina engqondweni ukuba i-SAMe ayifanele isetyenziswe ngokubambisana okanye kwindawo yonyango ekhuthazwa ngugqirha wakho. Ukuba ucinga ukuzama ukuxhaswa kwe-SAMe, qiniseka ukuba uthethe nodokotela wakho ukuba uqikelele ubungqina kunye neengxaki kwaye uxoxe ukuba kulungile kuwe.
> Imithombo:
> Galizia I, Oldani L, Macritchie K, et al. I-S-adenosyl Methionine (i-SAMe) yoKuNciphisa kwiBantu abadala. I-Cochrane Database Syst Rev. 2016 Oktobha 10; 10: CD011286.
> Guo T, Chang L, Xiao Y, Liu Q. I-adenosyl-L-methionine yoNyango lweSifo esiSigxina esingapheliyo: UkuHlola okuHlolo kunye neMeta-Uhlalutyo. PLoS One. 2015 Mar 16; 10 (3): e0122124.
> Porter NS, uJason LA, uBolton A, Bobabini N, Coleman B. Ukungenelela okuNyango lwezonyango ezisetyenziselwa unyango kunye noLawulo lwe-Myalgic Encephalomyelitis / Syndrome yoKhathazeka okungapheliyo kunye neFibromyalgia. J Altern Complement Med. 2010 Mar; 16 (3): 235-49.
Ukuziphendulela: Ulwazi oluqulethwe kule ndawo lujoliswe kwiinjongo zemfundo kuphela kwaye alithathi indawo yeengcebiso, ukuxilongwa okanye unyango ngumgqirha onelayisenisi. Akunakuthetha ukukhusela zonke iindlela zokulondoloza, ukusebenzisana kwezidakamizwa, iimeko kunye nemiphumo emibi. Kufuneka uncede unyango lwangonyango ngokukhawuleza kuyo nayiphi na imiba yempilo uze ubonane nodokotela wakho ngaphambi kokusebenzisa elinye iyeza okanye wenze utshintsho kwi-regimen yakho.