I-Lynch syndrome okanye i-HNPCC okanye i-non-polyposis yomdlavuza we-non-polyposis yandisa umngcipheko wokuphuhlisa i-colon nezinye i-cancer. Unonophelo lwezokwelapha kunye nenkqubo yokuhlola umhlaza epheleleyo ingakwazi ukulawula le mngcipheko.
I-Lynch Syndrome (i-HNPCC), i-Genetics, kunye neComment Cancer
Phantse i-75% yeeklinikliya zeekoloni ziimeko zentsholongwane . Oku kuthetha ukuba abanalo isizathu esaziwayo sofuzo okanye imbali yentsapho ebhaliweyo kumntu ofunyanwe nesifo.
Phakathi kwezinye izizathu zomdlavuza wekolon yi-Lynch syndrome okanye umhlaza we-non-polyposis umhlaza we-colorectal (HNPCC).
I-Lynch syndrome ibhalela i- 2-7% yeziganeko zesifo somhlaza esicatshungulwayo e-US. Ngenxa yokuba abantu abayi-160,000 bafumaneka ukuba banomdlavuza wamakholoni ngamnye ngonyaka, oku kuthetha phakathi kwama-3,200 kunye ne-11 200 kulawo matyala omhlaza wekolon abangelwa yi-Lynch syndrome.
Kanye nomngcipheko wokwanda komdlavuza wekoloni, abantu abane-Lynch syndrome banokubeka ingozi ekuphuhliseni ezinye i-cancer, ezibandakanya iintsholongwane ze-rectum, isisu, amathumbu amancinci, amathumbu angamaqanda, i-urinary tract, i-brain, i-skin, i-prostate, i-uterus ( i-endometrium), kunye nama-ovari. Imindeni apho i-Lynch syndrome ikhona khona inokholo olumandla lomhlaza. Xa uvavanyo lwemizimba lufumaneka ngokubanzi, ezininzi zeentsapho ziyazi ukuba zineenguqu zofuzo ezibangelwa i-Lynch syndrome.
Esi sizathu sokuba kubalulekile ukubhala imbali yakho yentsapho.
Abantu badla ukuba bacinge ngezinye iidlers njengelifa, kodwa xa zidibene ndawonye ikhonkco ivela.
I-Lynch Syndrome ifa njani?
I-Lynch syndrome idluliselwa kubazali kubantwana ngenxa yenguqu kwiijethi ezine: MLH1, MSH2, MSH6, kunye ne-PMS2. IziGenesis yincwadi yokufundisa yokwakha nokusebenza komzimba womntu.
Phantse yonke iseli emizimbeni yethu iqulethe ezimbini iikopi zomzimba ngamnye. Ikopi enye evela kumama wakho kunye nekopi enye evela koyihlo. Ngaloo ndlela, ukuba unina okanye utata unalo utshintsho kwisinye okanye ezininzi kwiijesi ezenza i-Lynch syndrome, banokudlulela olu tshintsho kubantwana babo, xa badlula kwiijim zabo.
Kwezinye izifo, ukuba enye yeekopi zeempawu zombini ilahlekile okanye ilahlekile, enye ikopi, ikopi elungileyo, iya kusebenza ngokuqhelekileyo kwaye ayiyi kuba nesifo okanye ingozi eyongezelelekileyo yesifo. Oku kubizwa ngokuba yi- autosomal pattern .
Kwezinye izifo, kuquka i-Lynch syndrome, ukuba kukho enye ikopi yeendiza zegesi ezimele okanye zilahlekile, oku kwanele ukwandisa umngcipheko okanye kubangela izifo. Oku kubizwa ngokuba yi-autosomal pattern. Nangona kunjalo, kubalulekile ukuba ukhumbule ukuba kuphela umngcipheko ophezulu womhlaza ozuze kwilifa kubantu abaneLynch syndrome. I-Cancer ayizuze ilifa kwaye akusiyo wonke umntu onayo i-Lynch syndrome eya kuba nomhlaza.
Ukongeza kwi-Lynch syndrome, kukho ezinye izixhumanisi zomfuzo kumdlavuza wekoloni ezibalulekile ukuqonda kwaye mhlawumbi ukuba ukudibanisa ngakumbi kuya kufumaneka kwixesha elizayo.
Okhuselekileyo
Siyambulela siphila kwixesha apho akudingeki ukuba ulinde uze ubone.
Kukho iindlela zokuvavanya i-genetics, kwaye nangona umntu enomngcipheko wemvelo, sifunda ngakumbi ngezinye iindlela zokunciphisa umngcipheko. Ukuba nenzala yentsapho yomhlaza ayisoloko iyinto embi xa ixhobisa abantu ukuba banakekele impilo yabo. Umzekelo wale ngxaki yomhlaza wesifuba, apho i-10% idibene ne-genetic link. Amabhinqa eneembali zentsapho zihlala ziqinisekisa ukuba zihlolwa kwaye azilindeli ukuba zikhishwe. Ukuba bahlakulela umhlaza, kungenokuba kufumaneke ngaphambili kunokuba umntu kwi-90% ongakhathalelekanga ngenxa yokungabikho kwembali yentsapho.
Ukucinga malunga neendlela ezikulo ndlela kuye kwabanceda abanye abantu ukuba bajongane nengozi yabo.
Ukululekwa ngeGenesis
Ukuba ufumanisa ukuba une-Lynch syndrome, xela ugqirha wakho malunga nokufumana ukuhanjiswa ukuze ubone umcebisi wezofuzo. Ugqirha wakho unokukunceda ukuba ufumane umcebisi we-genetic efanelekileyo kwindawo yakho okanye unokukhangela iNational Society ye-Genetic Counselors website ukuze ufumane izibonelelo zengcebiso zofuzo. Ukubona umcebisi wezofuzo kubalulekile kuba akukho konke utshintsho kwiijethi ezichaphazelekayo kubangelwa kwinqanaba elifanayo lomngcipheko womhlaza. Ezinye iinguqu zinokunyusa umngcipheko kuphela, ngelixa ezinye iinguqu zinokunyusa kakhulu ingozi yomhlaza. Kubalulekile ukwazi umngcipheko wakho ukuze uhlakulele isicwangciso sokuyilawula.
Ukukhangela umdlavuza
Isinyathelo sesibini esibalulekileyo ongayithatha kukuba uthethe ugqirha wakho malunga nesicwangciso sokuhlola umhlaza. Kwimiba emininzi yomhlaza, kuquka umdlavuza wekoloni, iimvavanyo zokuhlola iifumaneka kalula. Kwaye nangomdlavuza ongenalo uhlolo lokuhlola i-oceyiweyo, izixhobo ezifana ne-CT scans kunye neemvavanyo ze-MRI zingasetyenziselwa ukufumana umhlaza kwiinqanaba zokuqala, xa zinyango.
Njengoko negama elingenalo i-polyposis lomdlavuza ongqambileyo lisikisela, le meko ikwandisa ingozi yomdlavuza wekolon ngaphandle kokunyusa ingozi ye-polyps. Iipolisi zinyuka kwi-colon ukuba xa ingaphendulwanga, ingaba ngumhlaza wekoloni. Oku akuthethi ukuba abantu abane-syndrome yeLynch abazange bafumane iipolisi. Ibonisa nje ukuba bahlala behlakulela umdlavuza wekolon ngaphandle kokuqala ukuvelisa iipolisi. Ngenxa yeso sizathu, ukuhlolisisa i-colonoscopy kwesi sifo kunokuba nzima kakhulu, kodwa uphando lubonisa ukuba i-colonoscopy iyayifumana ngokwenene i-colon cancer ehambisana ne-Lynch syndrome. I-Colonoscopy iyindawo ebalulekileyo yokulawula i-Lynch syndrome.
Kuya kufuneka ukuba uhlolwe ukuba uqalise usemncinci kwaye uninzi rhoqo kunabantu abangenayo i-Lynch syndrome. Nangona oku kubonakala ngathi kukukhathazeka kakhulu, kuyona yezona ndlela ezintle zokulawula ingozi yakho yomhlaza, kuquka umhlaza wekolon.
Kukho iindaba ezilungileyo
Ngoxa kungekho mntu ufuna ukufumana i-Lynch syndrome, kukho enye yeendaba ezilungileyo malunga nale mfuzo. Ngo-2008, abaphandi baseNtaliyali baphicotha uphando olubonisa ukuba izigulane zomdlavuza eziqhelekileyo ezine-Lynch syndrome zenza ngcono ngakumbi kunezinye izigulane zomhlaza wekoloni. Abantu abane-Lynch syndrome banokuphila okungcono, kunye ne-94% yezi zigulane zisaphila iminyaka emihlanu emva kokuxilongwa, xa kuthelekiswa nemilinganiselo yokusinda iminyaka emi-5 engama -75% kubantu abanomdlavuza we-colon . Kukho izizathu ezininzi zezi zinto, ukususela ekuboneni kwangaphambili kubantu abane-Lynch syndrome kuba bangcono ngokufumana umhlaza wekoloni ukujonga ukungafani kwi-biology yeentlobo ezahlukeneyo zomhlaza wekoloni. Ngayiphi na indlela, ezi ndaba zikhuthazayo.
Imithombo
Coalition Colorectal Cancer. Lynch Syndrome. .http: //fightcolorectalcancer.org/prevent-it/risk-factors/lynch-syndrome
Izibuyekezo zeGene. I-Hereditary Non-Polyposis Cancer Colon. http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=hnpcc
Iziko leNgcaciso loLuntu lweGenesis neRareases. Ufikeleleke: 02/21/16. http://rarediseases.info.nih.gov/GARD/
Lindor NM. Ukwenza ityala lokuhlola i-colonoscopy kwi-Lynch syndrome. Isifo seColorectal, 2009 11: 131-32.
IiNational Institutes of Health. Lynch Syndrome. http://ghr.nlm.nih.gov/condition=lynchsyndrome