Uvavanyo lweGazi livavanya izifo emsebenzini kwiRheumatoid Arthritis
Kukho iimvavanyo ezimbalwa zegazi oogqirha abazenzayo ukuvavanya ukuvuvukala kunye nokunceda ukuxilonga i-arthritis. Iimvavanyo ezine zegazi eziqhelekileyo ezenzelwa kwizigulana ezikhankanywe ukuba ne- rheumatoid arthritis , okanye ukubeka esweni ukuphumelela kwonyango, zibandakanya izinga le-sedimentation ye-erythrocyte , i- CRP , i- rheumatoid factor , kunye ne-anti-CCP . Kodwa, kukho intsana "entsha" kwibhloko, ethetha ngokuthetha, ebizwa ngokuba yi-Vectra DA.
I-DA ye-Vectra, eyenziwe yiCrescendo Bioscience, i-test-multi-biomarker blood test yokuhlola isifo sesifo se-rheumatoid isifo sezilwanyana eziphathwe nge- DMARD ( izidakamizwa zokuguqula izidakamizwa) kunye neziyobisi ze-biologic . I-DA ye-Vectra iqokelela iplani yeeprotheyini ezi-12 eziphambili ezidibene ne-rheumatoid arthritis kwisinye uvavanyo oluvelisa injongo, amanqaku amaninzi anxulumene nomsebenzi wesifo. Amanqaku, 0-100 (amanqaku aphantsi abonisa umsebenzi ophantsi kwesifo), unceda oogqirha kunye nezigulane zenze izigqibo zonyango njengoko ziya phambili.
I-DA ye-Vectra yaqaliswa kuqala ngasekupheleni konyaka we-2010. Ukususela ngoko, ngokutsho kweCrescendo Bioscience, i-rheumatologists isebenzise ulwazi olwenziwe ngeso sixhobo ukuhlola umsebenzi wesifo kubantu abane-rheumatoid arthritis. I-DA ye-Vectra iyatholakala kuwo onke ama-50, kwaye uvavanyo luqhutywa kwiCrescendo Bioscience ye-Clinical Improvement Amendments (CLIA).
Emva kokuba isampuli yegazi ifunyenwe kwaye ivavanywe, iziphumo zibikwe kwiintsuku ezi-7 ukuya kwi-10. Oogqirha banokufumana iziphumo ngeendlela ezimbalwa ezahlukeneyo: iposi yeposi, ifeksi, okanye kwi-portal ye-Vectra View.
Hlola kunye ne-insurer yakho yangasese ukuqinisekisa ukuba i-DA ye-Vectra ifakwe ngomshuwalense wakho. I-Medicare igxininisa ngokugcwele i-Vectra DA engenakho ukuhlawulwa kwemali okanye ukuchithwa.
I-Crescendo Bioscience ifuna ukuqinisekisa ukuba indleko ayisoze ibe ngumqobo kubo nabani abane-rheumatoid arthritis abafanele babe novavanyo. Ungabiza u-1-877-I-RHEUMDX (1-877-743-8639) ukuze ufunde ngoncedo lwezezimali.
I-12 Biomarkers kwi-Vectra DA
I- biomarker yi-molecule emzimbeni onokulinganiswa kwaye ihlolwe ngokuchanekileyo. Isetyenziselwa ukuchonga umsebenzi oqhelekileyo okanye umsebenzi wesifo esingavamile, okanye ukusebenza kakuhle kwonyango.
I-VCAM-1 (i-molecular cell cell molecule-1) idlala indima ekusebenzisaneni phakathi kweeseli, imithana yegazi kunye nezicubu ezixhunyiwe kwidibeneyo. Ngamalungu athethwe yi-rheumatoid arthritis, ukusebenzisana kunokuncedisa ekwakheni amaseli avuthayo.
I-EGF (i-epidermal growth factor) iveliswa ngamaseli kwizicubu ezidibeneyo ezichaphazelekayo yi-arthritis ye-rheumatoid, ukukhuthaza ukukhula kweseli kunye nokuvutha.
I-VEGF-A (i-vascular endothelial growth factor A) ikhiqizwa ngamalungu atshabalalayo, egalela ekuveleni kweempahla zegazi, i-buildup yamanzi kunye nokukhukhula kwethambo.
I-IL-6 (interleukin 6) iqhuba ukuvuvukala, ukubola kwe-cartilage, kunye nokuguguleka kwethambo ehambelana nesifo se-rheumatoid arthritis.
I-TNF-RI (i-tumor necrosis factor receptor, uhlobo 1) i-receptor ye-TNF-alpha, enye i-molecule eqhuba ukuvuvukala kunye nokutshatyalaliswa.
I-MMP-1 (i-matrix metalloproteinase-1 okanye i-collagenase-1) yi-enzyme eyenza ukutshabalalisa i-cartilage kwi-rheumatoid arthritis.
I-MMP-3 (i-matrix metalloproteinase-3 okanye i-stromelysin-1) yi-enzyme etshabalalisa izixhobo ze-cartilage.
I-YKL-40 yiprothini enceda ukulawula ukulungiswa kwamathambo nokutshabalalisa.
I-Leptin i-hormone efihliweyo ngamathambo enqatha, iiseli kwiisisombululo ezihlangeneyo kunye namathambo. I-Leptin inegalelo ekuvukeleni kwaye ilawula ukulungiswa kwethambo.
I-Resistin i-hormone ifihliwe ngamaseli kwindawo edibeneyo kunye nesithambo esibangela ukuvuvukala nokulawula ukulungiswa kwethambo.
I-SAA (i-serum amyloid) yiprotheyini eveliswa sisibindi ngokuphendula ukuvuvukala.
I-serum amyloid inokuveliswa ngamathambo ahlangeneyo, apho iyakwenza khona iisununu kunye namajoni omzimba.
I-CRP ( ip -protein esebenzayo) iveliswa sisibindi ngokuphendula ukuvuvukala.
Iphi Isingqinisiso Sakho Sithetha
Ukutolika amanqaku akho kubalulekile: 45 ukuya ku-100 ibonisa izinga eliphezulu lezenzo zesifo; 30 ukuya ku-44 ibonisa umsebenzi wesifo esifanelekileyo; kwaye 1 ukuya ku-29 ibonisa izinga eliphantsi lomsebenzi wesifo.
Ngaphantsi
Uvavanyo lwe-Vectra lwe-DA lufanelekile kwizigulane sele zifumene i-rheumatoid arthritis. AKUSETYENZISWA ukuxilonga i-arthritis. Ihlola umsebenzi wesifo.
Ngo-2016 EULAR (i-European League echasene neRheumatism) kwintlanganiso yonyaka, iziphumo zophando zenziwe zibonise, ngaphezu kwe-tracking activity activity, i-DA ye-Vectra "inokuqikelela ukutshatyalaliswa kunye nokugcinwa kwezigulane kwizigulana zokuyeka unyango, kunye nokunyanga kwonyango kwi-biologic nangaphandle -biologic therapies. "
> Imithombo:
> I-DA yeVectra. Uvavanyo lweMisebenzi.
> I-Crescendo Bioscience Izisa ukuba iNew Data kwi-Vectra DA iya kunikwa kwi-European League ngokumelene neRheumatism 17th Annual Congress. Crescendo Bioscience. Juni 10, 2016.