Kuxhaphakile ngoku ukuba abantu banikele ngamaseli e-blood stem cell (PBSCs) zokutshintshwa, nangona kwezinye iimeko abantu benikela ngomongo wethambo. Ukuba ucinga ukunikela ngomongo wethambo esikhundleni se-PBSCs khangela iingozi zokunikela ngomongo wethambo .
Ukuqokelela kweeStem eSezi zePhepha
Ukuqonda iingozi ezinokuthi zinikele ngeeseli ezinamaqabunga, kunokunceda ekuhlaziyweni kokuqala inkqubo yeendlela esele ziqokelelwa ngayo ukufakelwa.
Ukuqala kwiintsuku ezi-4 okanye kwi-5 ngaphambi kokuba inqubo iya kunikelwa ijojo ukwenzela ukwandisa inani leeseli ezinamafutha egazini lakho. Inqubo ngokwayo iqhutyelwa nge-IV ebekwe kwingalo yakho okanye umgca ophakathi kwinqanawa ephezulu yegazi. Igazi lakho liqokelelwe, lihlanjululwe ukususa iisensi ze-stem, idluliselwe emzimbeni wakho.
Ingozi
Kukho iingcipheko ezimbalwa ezihlukeneyo zokuqwalasela kwingxowankulu yegazi ye-cell stem.
Iyokuqala inxulumene namachiza owamkelayo ngexesha leentsuku ngaphambi kokuba kwenziwe inkqubo. Iyeza elithethwa njengegranulocytes colony stimulating factor (Neupogen) lidlalwa imihla ngemihla iintsuku ezi-4 okanye ezi-5 ngejoyiki, ukwenzela ukwandisa inani lamaseli e-stem egazini lakho. Imiphumo emibi yale mayeza idla ngokuquka intlungu yesifo, kunye nomngcipheko wokuphendula. Ngesinye isikhathi bekucingelwa ukuba i-granulocyte eyakhayo inokunyusa umngcipheko we-leukemia kulabo abayifumene nayo, kodwa loo nto ayibonakali ukuba kunjalo, kwaye kwisifundo esinye esikhulu iziganeko ze-leukemia kubantu abafumene i-granulocyte into ekhuthaza Ukulungiselela ukunikezela ngeeseli ezincinci kuncinci kuncinci kunomyinge kubemi.
Umngcipheko wesibini ochaphazelekayo unxulumene negazi elizenzelayo. Ngamanye amaxesha ukwenzela ukubeka i-IV, umgca ophakathi kufuneka ufakwe kwi-vein enkulu emzimbeni wakho. Oku kubeka umngcipheko wegazi kunye nomngcipheko onqabileyo wokubetha enye yemiphunga yakho. Ekubeni igazi lakho (minus cell cells) libuyiselwa emzimbeni wakho, awuyi kuba nempawu ezininzi zabantu ezidibanisa nokunikela ngegazi.
Ngelixa igazi lakho lihlanjululwa (inkqubo ebizwa ngokuthi i-apheresis) unokuba uzive ulula. Unokuba neenkwenkwezi, iintlanzi ezandleni zakho, kunye neengxaki zokugubha emlonyeni wakho. Oku okwethutyana kwaye akuphiki ixesha elide kuneeyure ezimbalwa emva kokuba inkqubo yokuqokelela iyenziwe.
Ubungozi obuhle kunye neempembelelo ezingasemva
Imiphumo echaphazelekayo yinkxalabo ye-cell stem donation ngokuqhelekileyo iyenzeka kwiintsuku ngaphambi kokuba umnikelo kwaye ihambelana nemiphumo emibi yejojo ye-granulocyte. Ezi ziquka intlungu yethambo kunye namaqhwa omzimba.
Kukho ukungahambi kakubi ngokufaka i-IV, kunye ne-chills kunye ne-cramps ngezandla njengoko kuchaziwe ngasentla.
Iingozi kunye Neempembelelo Zecala
Iziganeko ezingathandekiyo ezibi kakhulu aziqabile nge-stem cell cell donation. Ekuhlaziyweni kweminikelo yoNcedo lweMarrha kaZwelonke, ngaphantsi kwe-1% yabanikeli abanesifo esibi kakhulu.
Ehlabathini lonke, olunye uphando lukhangele abantu abangaphezu kwama-23,000 abaye banikela ngamaseli e-blood stem. Phakathi kwala bantu, kwakukho izifo ezi-4 kunye neziganeko ezingathandekiyo ezinzulu (ikakhulu ezinxulumene nentliziyo), kodwa isifundo sasiquka iinkqubo ezijikeleze ihlabathi ngeemfuneko ezingqongqo ezixhasayo kubaxhasi abo baseMelika.
Abaxhasi kunye nezigulane
Ukuba ucinga ukunikela ngeeseli ezinqabileyo kumntu ongaphandle kwentsapho yakho, unokuzibuza ukuba uya kuba nethuba lokuthetha nommkeli weeseli zakho. Kukho iinkqubo eziyimfihlo eziyimfihlo malunga nalokhu, kodwa kunokukhuthaza ukuba ufunde amabali abaxhasi kunye nezigulane eziye zafumana ithuba lokudibana.
Ukwenza Isigqibo Sakho
Ngokubanzi, ukunikela ngegazi le-peripheral kubonisa ukuba iiseli yinkqubo ekhuselekileyo, enokukwazi ukusindisa ubomi. Ukuba ucinga ukunikela, thatha ixesha lokulinganisela ingozi kunye neenzuzo, kwaye unqume oko kukulungele.
Imithombo:
I-American Society ye-Clinical Oncology. Cancer.Net. Ukunika iMarrow Bone.
Halter, J., Kodera, Y., Ispizua, A. et al. Iziganeko ezinzima kubaxhasi emva kwe-allogeneic hematopoietic stem cell donation. Haematologica . 2009. 94 (1): 94-101.
Miller, J., Perry, E., Price, T. et al. Iiprofayili zokubuyisela kunye nezokhuseleko zomnkantsha kunye nabaxhasi be-PBSC: amava kwiNkqubo yoNika iMarrow yeNational. I-Biology ye-Bone Marrow Transplantation . 2008. 14 (9 I-Suppl): 29-36.
Iprogram yoNika iMarrow yeSizwe. Ukunika iMarrow Bone.