I-Juxtapid (i-lomitapide) yonyango esetyenziselwa kakhulu imilinganiselo ye-cholesterol epheleleyo, i-LDL, kunye nama- apolipoprotein B amanqanaba - kunye nokutya kunye nezinye iindlela zokwelapha-kubantu abane-homozygous family hypercholesterolemia , imeko engabonakaliyo, ezuze ifa elidala i-LDL ephezulu ye-cholesterol namaqondo kwisifo ebomini. I-Juxtapid yavunyelwa ukuba isebenziswe eUnited States yi-Food and Drug Administration ngoDisemba 2012.
I-Juxtapid ifunyenwe ngokucokisekileyo kubantu abaxilongwa nge-homozygous family hypercholesterolemia - kwaye kungekhona kubantu abanezinye iimeko ezibangele amazinga aphezulu e-cholesterol. Kwisifundo esinye, iJuxtapid 5 ukuya kwi-60 mg yemihla ngemihla yayikelwe kubantu abathile bathatha ezinye iindlela zokunciphisa i-cholesterol kwizinga eliphezulu ze-LDL ze-cholesterol. Olu pho nonongo luye lwabonisa ukuba ukongeza iJuffapid kwezinye iindlela zokwelapha zinciphisa amazinga e-LDL ngama-50%. Amanqanaba e-Triglyceride, amanqanaba e-apolipoprothein B, i-VLDL kunye namazinga e-cholesterol ewonke nawo ancitshiswa kakhulu.
Olunye uhlolisiso luhlolisise ukusebenza nokukhuseleko kubantu abanobuhlobo bonyango obufanayo bathatha iJuxtapid yedwa ukuhlahlisa iqondo le-cholesterol. Ekugqibeleni kwesi sifundo, kwinqanaba le-1 mg / kg / ngosuku, amazinga e-LDL kunye nama-apolipoprothein B ayancitshiswa ngama-50%.
Nangona ezi ziphumo zancedisa i-cholesterol engaphantsi kwesi si gulane, ziye zabonisa ukuba iJuxtapid inokubangela iziphumo ezibi kakhulu-kubandakanywa nemiphumo yesisu kunye nesifo sesibindi.
Ukongezelela, ekubeni ezi zifundo zithatha iiveki ezingama-78 kuphela, ezinye iinjongo ziqhutyelwa ngokukhawuleza ukufumana ukhuseleko lwexesha elide kunye nokusebenza kweJuxtapid.
Ingaba isebenza kanjani?
I-Juxtapid inciphisa i-cholesterol ye-LDL ngokuthintela iprotheni yokudlulisa i-microsomal proglyceride (MTTP), i-molecule emzimbeni ovimbela i-VLDL kunye ne- chylomicron ukuba zenziwe esibindi.
Ngenxa yokuba i-VLDL iguqulwa ibe yi-LDL, oku kuya kunciphisa amanqanaba e-LDL egazini.
Ndingayifumana Njani Le Milisi?
I-Juxtapid kufuneka ithathwe ngomlomo, ngeglasi yamanzi, kwisisu esingenanto. Kucetyiswa ukuba amayeza athathwe ubuncinane iiyure ezimbini emva kokutya. Umboneleli wakho wezempilo uya kuhlola iimvavanyo zegazi - kubandakanya ukuhlola ii-enzyme zesibindi kunye namazinga e-cholesterol - ngaphambi kokumisela i-Juxtapid kuwe.
Iimiphumo zangaphandle
Ama-enzyme ephakamileyo enesibindi kunye nokuqokelela kwamafutha esibindi kuye kwaxhamla kakhulu ngokuthatha iJuxtapid. Ngoko ke, ugqirha wakho uya kufuneka ukuba athathe uvavanyo lwegazi ngexesha elizeleyo ukwenzela ukuba akhombe amanqanaba enzyme yakho, equka i-alanine aminotransferases, i-aspinate aminotransferases kunye ne-alkaline phosphatase, ngaphezu kokubeka esweni i-cholesterol yakho. Ngenxa yeziphumo zecala, iJuxtapid ithatha "isilumkiso esimnyama ebhokisini" yesifo se-hepatotoxicity, esiyisixwayiso esinamandla esikhutshwe yi-Food and Drug Administration ngenxa yokuba le mpembelelo yecala ichazwe kwiziphumo zokuhlola ukhuseleko lweziyobisi. Ngenxa yempembelelo enokulimaza i-Juxtapid inesibindi, ugqirha wakho uya kubhalisa kwiprogram ekhuselekile, ekubhekiselwe kuyo njengeprogram ye-Juxtapid REMS.
Ngaphantsi kweli program, kuphela oogqirha kunye nee-pharmacy eziqinisekisiweyo ekuqondeni iyeza kunye nemingcipheko yayo inokumisela nokusabalalisa iJuxtapid.
Imiphumo yesisu esiswini, njengesihlunu, ukuhlanza, ukutshaya, ukurhoxiswa, isisu kunye nentlungu yesisu, kuye kwaba yimiphumo ebume kakhulu echazwe kubantu abathatha iJuxtapid. Abanye abantu baye baxela ukulahlekelwa kwesisindo, intlungu yesifuba, kunye nokukhathala ngelixa bethatha amayeza.
Ngubani Akufanele Awathabathe?
Okwangoku, iJuxtapid ifunyenwe kuphela kubantu abaxilongwa nge-homozygous family hypercholesterolemia ngenxa yobungozi obuphezulu besifo senhliziyo.
Ngenxa yoko, awaziwa ukuba i-Juxtapid iyasebenza kubantu abanezinye izimo zonyango ezibangela amazinga aphezulu e-cholesterol. Abanye abantu abamele badibane nodokotela wabo ngaphambi kokuba bathathe iJuxtapid zibandakanya:
- Abantu abaneentsholongwane zesibindi - i-Juxtapid inokunyusa ukwandisa i-enzyme yesibindi njenge-transaminase kunye nokwandisa i-fat fat.
- Abantu abanesifo seengtso - amazinga akwaJuxtapid anganyuka egazini.
- Abafazi abakhulelwe - iJuxtapid iboniswe ukuba inobungozi kumntwana wesifundo kwizilwanyana. Abasetyhini abanako ukuvelisa baya kufuneka babe nokuvavanya okungahambiyo ngaphambi kokuqala iJuxtapid kwaye kuya kufuneka basebenzise uhlobo oluthile lolawulo lokuzalwa ngokufanelekileyo ngelixa bathabatha amachiza.
- Abasetyhini abanomdla - iJuffapid ayizange ifundwe ngokubanzi. Ngenxa yokuphuhliswa kwesisu kumagundane, kucetyiswa ukuba unesi-okanye isilwanyana-kufuneka ishiywe.
Ukusebenzisana kweziyobisi
Kukho amayeza athile angabelana noJuxtapid, oku kunokubangela ukuba kuthintele uxinzelelo lweJuxtapid okanye amanye amayeza emzimbeni. Oku kuluhlu olutshanje lweemithi ezinokusebenzisana noJuxtapid ngoko ukuba uthatha enye okanye ngaphezulu kwezi zonyango, kufuneka uqhagamshelane nodokotela wakho.
- Iivithamini ze-vitamines kunye nezondlo, ezifana neeVithamini A, D, E, kunye ne-K, kunye ne- omega-3 fatty acids , azinakunyuswa kunye nokuthatha i-Juxtapid.
- I-Juxtapid inokunyusa amanqanaba egazini lamagazi athile, njenge-warfarin, egazini. Oku kunokubangela ukuba uphephe okanye utyumle ngokulula.
- Ukuba uthatha i-atorvastatin okanye i-simvastatin, i-Juxtapid inokunyusa amanqanaba egazi ala mayeza. Ugqirha wakho unokuguqula umthamo wakho wale mayeza ngelixa uthatha iJuxtapid.
Ngenxa yendlela indlela iJuxtapid idibene ngayo emzimbeni, inokunyusa amanqanaba egazi lamanye amachiza owathathayo - ngoko ukwenza ukuba imichiza ibe yingozi kakhulu. Ezi ziquka izidakamizwa ezithile ezichasayo, iziza-antibiotics, iziyobisi zonyango, imishanguzo yegazi, iziyobisi ezisetyenziselwa ukuguqula i-heartburn, kunye nemveliso yemvelo (njengegolide, iidipefruit). Ngoko ke, kufuneka ugcine zonke iinkonzo zakho zononophelo lwempilo zikwaziswa nayiphi na imichiza oyithathayo ukuze bakwazi ukukhenketisa ngokwaneleyo ukusebenzisana kunye noJuxtapid. Ugqirha wakho unokugqiba isigqibo sakho sokuguqula umthamo wakho weJuxtapid okanye amanye amayeza xa kuthethwa ukusebenzisana.
Okukwintsusa
I-Juxtapid yipilisi yokuqala yokunciphisa i-cholesterol evunyelwe ukuba inqande iTTP. Nangona uphando lubonise ukuba i-Juxtapid yongeza amandla angaphezulu kwe-LDL-ekunciphiseni abantu abane-hyzycholesterolemia, kunye neemeko zokhuseleko ezinxulumene neJuffapid kunye nokusetyenziswa kwayo kugcinwe kulo mqathango wesifo ngenxa yengozi. Ugqirha wakho uza kuhlola iingenelo zokuthatha iJuffapid, kunye neengozi zokufumana iziphumo ezibi kunye neziyobisi. Ngenxa yokuba igalelo lexesha elide lokuthatha iJuxtapid alingaziwa - kuquka ukukwazi ukukhusela isifo senhliziyo - kukho izifundo eziqhubekayo ukuhlola oku.
Imithombo:
I-Cuchel M, Meagher EA, Theron HD, et al. Ukusebenza kunye nokukhuselwa kwe-prohibitridial triglyceride yokudlulisa iprotheni inhibitor kwizigulana ezine-homozygous family hypercholesterolemia: ingalo enye, i-ilebula evulekileyo, isifundo sesi-3. Lancet 2013; 381 (9860): 40-6.
UChekhel M, iBloedon LT, uSizapary PO, et al. Ukuvinjelwa kweprotheni yokudlulisa i-microsomal i-triglyceride kwi-family hypercholesterolemia. N Eng J Med 2007; 356: 148-156.
Juxtapid ® (i-omitapide) Iphakheji Faka. Aegerion Pharmaceuticals. Matshi 2016.