Iimpawu, ukuxilongwa kunye nokunyangwa kwe-Pheochromocytoma
I-pheochromocytoma luhlobo lwe-tumor efunyenwe kwiingqungquthela ze-adrenal okanye ezinye iiseli zesisindo. Ezi zicubu zinqabile kakhulu kodwa zingabangela iimpawu ezintle kuba zivame ukubethelela inani elikhulu lamahomoni athile abizwa ngokuthi ama- catecholamines . Nangona ezinye i-pheochromocytomas zinokuvela kwiiseli zesisongela, phantse zonke zivame ukufunyanwa kwelinye lalezi zimbini ze-adrenal.
Ezi zicubu ziphantse zihlala zingenomdlavuza, kodwa zifuna unyango ngenxa yamakhono abo okukhupha i-hormone.
Iimfundiso malunga nePheochromocytoma kunye noPhuzo lweGazi
- I-Pheochromocytomas zivelisa amanqanaba aphezulu eekhemikhali ezibizwa ngokuba yi-catecholamines, eziyimimoni ehambelana nexinzelelo, kwaye zenza kwi-cardiovascular system ukunyusa izinga lentliziyo, uxinzelelo lwegazi kunye nokuhamba kwegazi.
- Ezi zicubu zivame ukuvelisa i-epinephrine (i-adrenaline), i-norepinephrine kunye ne-dopamine-iimbumba ezintathu eziphakathi kwezona ziqinileyo ziyaziwayo ngokunyuka kwengcinezelo yegazi . Ngokuqhelekileyo umzimba usebenzisa amaxabiso amancinci ala ma khemikhali ukuphendula kwiimeko eziyingozi okanye ezixinzelelekileyo.
- Nangona zixabiso elincinane, zonke ezintathu zineempembelelo ezinkulu kwixinzelelo legazi.
- Ngenxa yokuba i-pheochromocytomas ivelisa ubuninzi bee-hormone nganye, iziphumo kwixinzelelo lwegazi zivakala kakhulu.
- Phantse zonke izigulane ezine-pheochromocytomas ziye zaphakamisa uxinzelelo lwegazi, kwaye uphawu oluphezulu lwexinzelelo lwegazi olubangelwa yilo meko luxinzelelo olukhulu lwegazi olujikelezayo emini.
Iimpawu kunye neempawu zePheochromocytoma
Iqela eliqhelekileyo leempawu kwiimeko ze-pheochromocytoma libhekiswa "njenge-triad" kwaye liqukethe:
- Intloko
- Ukujuluka okukhulu
- Tachycardia
Ukunyuka kwengcinezelo yegazi, ngokuqhelekileyo kuphakanyiswe kakhulu, yimiqondiso eqhelekileyo kwizigulane nge-pheochromocytoma. Eminye, iimpawu ezingezona ziqhelekileyo ziquka:
- Iingxaki ezibonakalayo (umbono ongezantsi)
- Ukuhla ukusinda
- Ukomeleza ngokweqile / ukucoca
- Ishukela ephezulu yegazi
Zonke ezi zimpawu zibangelwa zizifo ezahlukileyo, ngoko kubalulekile ukuba uhlolwe ngugqirha.
I-Pheochromocytoma Diagnosis
Uninzi lwama-pheochromocytomas lufunyenwe ngokukodwa ("ngengozi") ngexesha lohlobo oluthile lokufunda i-imaging (MRI, CT Scan) eyenziwa ngxaki engalinganiyo. Izidumbu ezifunyenwe ngale ndlela zibukeka zifana nesincinci okanye ubunzima obukuloo ndawo. Imbali yentsapho okanye iindidi ezithile zeenkcukacha zonyango zingabonisa ugqirha ukuba i-pheochromocytoma ikhona.
Ezi zicubu zidibaniswe nezinye, iimeko ezingaqhelekanga zezofuzo. Ukuxilongwa ngokuqhelekileyo kuquka ukulinganisa amaninzi e-hormone yegazi ngaphezu kwexesha elifutshane (iiyure ezingama-24 ziqhelekileyo), kunye nokuthatha imifanekiso yesifuba nesisu esiswini. Ngamanye amaxesha "iimvavanyo zomngeni" ziqhutyelwa, apho ugqirha uya kujoba enye into, ulinde ixesha elifutshane, uze ulandele igazi uze ukhangele ukuba i-injection injected upi inani lama-hormone egazini.
Pheochromocytoma unyango
Zonke i-pheochromocytomas kufuneka zicinywe ngugqirha. Nangona ixinzelelo legazi ngokungekho nto ebalulekileyo ekunqumeni ukuba okanye kungenzi ukwenza utyando, le ngenye yeemeko ezinqabileyo apho kukho ukuzama ukunciphisa uxinzelelo lwegazi ngaphambi kokuhlinzwa.
Izizathu ezi zinto ziyinkimbinkimbi kodwa zixubene nokuba le yingozi enkulu kwaye ingozi yokuhlinzwa.
Ukunciphisa umngcipheko, kusetyenziswe amanyathelo amiselweyo amanyathelo, nangona ezinye zezi nyathelo zivame ukuphakamisa uxinzelelo lwegazi. Ekubeni uxinzelelo lwegazi luhlala seluphakanyisiwe, ukwanda okwanda kunokuba yingozi. Utyando oluya kwenziwa luza kwenziwa ngutitshala kunye neemvavanyo ezizodwa ziya kwenziwa kwimizuzu emibini nangemva kokuhlinzwa ukuze kuqinisekiswe ukuba i-tumor iyasuswa.
Imithombo:
Baguet, JP, Hammer, L, Mazzuco, TL, et al. Iimeko zokufumanisa i-phaeochromocytoma: uphando oluthile lwezigulane ezingama-41 ezilandelelanayo. I-European Journal ye-Endocrinology 2004; 150: 681.
Bravo, EL. Ukuguqula iingcamango kwi-pathophysiology, ukuxilongwa, kunye nokunyangwa kwe-pheochromocytoma. Ukuhlolwa kwe-Endocrinology 1994; 15: 356.
Oishi, S, Sasaki, M, Ohno, M, et al. Ukuguqulwa kwexesha elikhoyo lwexinzelelo lwegazi kunye nabaphathi balo kwizigulane ezine-pheochromocytoma. Ingxelo yenkcazo kunye nokuhlaziywa kweencwadi. IJapan Heart Journal 1988; 29: 389.
Stein, PP, Black, HR. Indlela elula yokufumanisa i-pheochromocytoma. Ukuhlaziywa kweencwadi kunye neengxelo zamava eziko elinye. Amachiza (iBaltimore) ngo-1991; 70:46.
Ulchaker, JC, Goldfarb, DA, Bravo, EL, Novick, AC. Iziphumo eziphumelelayo kwi-pheochromocytoma ukuhlinzwa kwixesha langoku. Journal of Urology 1999; 161: 764.